[Monotherapy trial with selegiline in de novo parkinsonian patients] Members of the French research group for testing selegiline in early Parkinson disease].
Identifieur interne : 006448 ( Main/Merge ); précédent : 006447; suivant : 006449[Monotherapy trial with selegiline in de novo parkinsonian patients] Members of the French research group for testing selegiline in early Parkinson disease].
Auteurs :Source :
- Therapie [ 0040-5957 ]
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Selegiline.
- geographic : France.
- drug therapy : Parkinson Disease.
- Aged, Double-Blind Method, Drug Evaluation, Female, Humans, Male, Middle Aged.
Abstract
The French selegiline (S) multicenter trial was conducted in 1990 to test the possibility to improve symptomatology of de novo parkinsonian patients (PP) during the first three months of treatment by monotherapy S 10 mg/day. A randomized double blind placebo, parallel controlled trial was carried out on 93 patients in 13 neurologic centers. S appears superior to placebo. Global scores and motor subscores of UPDRS are improved (p < 0.001, p < 0.01) from the first to the third month. Side effects are minor (nausea, dysgueusia, vertigo, lipothymia) and hardly different in both groups. S thus appears as inducing a rapid and moderate symptomatic effect in de novo PP, during a 3 months long period of treatment.
PubMed: 8140562
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pubmed:8140562Le document en format XML
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<date when="????"><PubDate><MedlineDate>1993 May-Jun</MedlineDate>
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<series><title level="j">Therapie</title>
<idno type="ISSN">0040-5957</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Drug Evaluation</term>
<term>Female</term>
<term>France</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Selegiline (therapeutic use)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Selegiline</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<term>Double-Blind Method</term>
<term>Drug Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">The French selegiline (S) multicenter trial was conducted in 1990 to test the possibility to improve symptomatology of de novo parkinsonian patients (PP) during the first three months of treatment by monotherapy S 10 mg/day. A randomized double blind placebo, parallel controlled trial was carried out on 93 patients in 13 neurologic centers. S appears superior to placebo. Global scores and motor subscores of UPDRS are improved (p < 0.001, p < 0.01) from the first to the third month. Side effects are minor (nausea, dysgueusia, vertigo, lipothymia) and hardly different in both groups. S thus appears as inducing a rapid and moderate symptomatic effect in de novo PP, during a 3 months long period of treatment.</div>
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