The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures
Identifieur interne : 005870 ( Main/Merge ); précédent : 005869; suivant : 005871The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures
Auteurs : P. P. Michel [France] ; Yves Agid [France]Source :
- Brain research [ 0006-8993 ] ; 1992.
Descripteurs français
- Pascal (Inist)
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Abstract
The neuroprotective effects of MK-801, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor/channel, were assessed in a culture model which reproduces in vitro the selective degeneration of mesencephalic dopaminergic neurons seen in parkinsonian brains. Dissociated mesencephalic cells derived from rat embryonic brains were subjected for 24 h to intoxication by the 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
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Pascal:93-0110415Le document en format XML
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Michel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS INSERM, hôp. salpêtrière</s1><s2>75013 Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0110415</idno><date when="1992">1992</date><idno type="stanalyst">PASCAL 93-0110415 INIST</idno><idno type="RBID">Pascal:93-0110415</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A83</idno><idno type="wicri:Area/PascalFrancis/Curation">001568</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001947</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001947</idno><idno type="wicri:doubleKey">0006-8993:1992:Michel P:the:glutamate:antagonist</idno><idno type="wicri:Area/Main/Merge">005870</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP<sup>+</sup>) in rat dissociated mesencephalic cultures</title><author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P. P." last="Michel">P. P. Michel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS INSERM, hôp. salpêtrière</s1><s2>75013 Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1992">1992</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Cell death</term><term>Degeneration</term><term>Dopaminergic neuron</term><term>Experimental disease</term><term>Glutamate</term><term>Midbrain</term><term>NMDA receptor</term><term>Neurotoxin</term><term>Parkinson disease</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Glutamate</term><term>Dizocilpine</term><term>Récepteur NMDA</term><term>Dégénérescence</term><term>Neurone dopaminergique</term><term>Mésencéphale</term><term>Mort cellulaire</term><term>Parkinson maladie</term><term>Pathologie expérimentale</term><term>Neurotoxine</term><term>Animal</term><term>Rat</term><term>Neuroprotecteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neuroprotective effects of MK-801, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor/channel, were assessed in a culture model which reproduces in vitro the selective degeneration of mesencephalic dopaminergic neurons seen in parkinsonian brains. Dissociated mesencephalic cells derived from rat embryonic brains were subjected for 24 h to intoxication by the 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>), the active metabolite of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P. P." last="Michel">P. P. Michel</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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