The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures
Identifieur interne : 005870 ( Main/Merge ); précédent : 005869; suivant : 005871The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures
Auteurs : P. P. Michel [France] ; Yves Agid [France]Source :
- Brain research [ 0006-8993 ] ; 1992.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The neuroprotective effects of MK-801, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor/channel, were assessed in a culture model which reproduces in vitro the selective degeneration of mesencephalic dopaminergic neurons seen in parkinsonian brains. Dissociated mesencephalic cells derived from rat embryonic brains were subjected for 24 h to intoxication by the 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
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Pascal:93-0110415Le document en format XML
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) in rat dissociated mesencephalic cultures</title>
<author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P. P." last="Michel">P. P. Michel</name>
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<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
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) in rat dissociated mesencephalic cultures</title>
<author><name sortKey="Michel, P P" sort="Michel, P P" uniqKey="Michel P" first="P. P." last="Michel">P. P. Michel</name>
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<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
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<series><title level="j" type="main">Brain research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Cell death</term>
<term>Degeneration</term>
<term>Dopaminergic neuron</term>
<term>Experimental disease</term>
<term>Glutamate</term>
<term>Midbrain</term>
<term>NMDA receptor</term>
<term>Neurotoxin</term>
<term>Parkinson disease</term>
<term>Rat</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Glutamate</term>
<term>Dizocilpine</term>
<term>Récepteur NMDA</term>
<term>Dégénérescence</term>
<term>Neurone dopaminergique</term>
<term>Mésencéphale</term>
<term>Mort cellulaire</term>
<term>Parkinson maladie</term>
<term>Pathologie expérimentale</term>
<term>Neurotoxine</term>
<term>Animal</term>
<term>Rat</term>
<term>Neuroprotecteur</term>
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<front><div type="abstract" xml:lang="en">The neuroprotective effects of MK-801, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor/channel, were assessed in a culture model which reproduces in vitro the selective degeneration of mesencephalic dopaminergic neurons seen in parkinsonian brains. Dissociated mesencephalic cells derived from rat embryonic brains were subjected for 24 h to intoxication by the 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>
), the active metabolite of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)</div>
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