Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease
Identifieur interne : 005640 ( Main/Merge ); précédent : 005639; suivant : 005641Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease
Auteurs : A. Kastner [France] ; E. C. Hirsch ; Yves Agid [France] ; F. Javoy-AgidSource :
- Brain research [ 0006-8993 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Analyse quantitative, Homme.
English descriptors
- KwdEn :
Abstract
To analyze the roles of transcriptional and post-transcriptional regulatory mechanisms of tyrosine hydroxylase (TH) gene expression during dopaminergic denervation in Parkinson's disease (PD), the cellular content of TH messenger RNA (mRNA) and TH protein in the substantia nigra were compared in control subjects and patients with PD. The average amounts of TH mRNA as well as those of TH protein per neuron were variable among controls but correlated to each other. In PD patients, both TH mRNA and TH protein content in nigral neurons were reduced relative to controls, however, the ratio between TH protein and TH mRNA levels was unaffected
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Pascal:93-0340711Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease</title><author><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0340711</idno><date when="1993">1993</date><idno type="stanalyst">PASCAL 93-0340711 INIST</idno><idno type="RBID">Pascal:93-0340711</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A61</idno><idno type="wicri:Area/PascalFrancis/Curation">001590</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001856</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001856</idno><idno type="wicri:doubleKey">0006-8993:1993:Kastner A:tyrosine:hydroxylase:protein</idno><idno type="wicri:Area/Main/Merge">005640</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease</title><author><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U289</s1><s2>75013 Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dopaminergic neuron</term><term>Gene expression</term><term>Human</term><term>Immunohistochemistry</term><term>Molecular hybridization</term><term>Parkinson disease</term><term>Quantitative analysis</term><term>Tyrosine 3-monooxygenase</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tyrosine 3-monooxygenase</term><term>Neurone dopaminergique</term><term>Parkinson maladie</term><term>Expression génique</term><term>Analyse quantitative</term><term>Immunohistochimie</term><term>Hybridation moléculaire</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse quantitative</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To analyze the roles of transcriptional and post-transcriptional regulatory mechanisms of tyrosine hydroxylase (TH) gene expression during dopaminergic denervation in Parkinson's disease (PD), the cellular content of TH messenger RNA (mRNA) and TH protein in the substantia nigra were compared in control subjects and patients with PD. The average amounts of TH mRNA as well as those of TH protein per neuron were variable among controls but correlated to each other. In PD patients, both TH mRNA and TH protein content in nigral neurons were reduced relative to controls, however, the ratio between TH protein and TH mRNA levels was unaffected</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Kastner, A" sort="Kastner, A" uniqKey="Kastner A" first="A." last="Kastner">A. Kastner</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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