Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease ?
Identifieur interne : 005449 ( Main/Merge ); précédent : 005448; suivant : 005450Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease ?
Auteurs : A. Mouatt-Prigent [France] ; Yves Agid [France] ; E. C. HirschSource :
- Brain research [ 0006-8993 ] ; 1994.
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- Pascal (Inist)
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English descriptors
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Abstract
Parkinson's disease (PD) is characterized by a heterogeneous loss of dopaminergic neurons in the human mesencephalon affecting mainly the substantia nigra pars compacta (SNpc) and to a lesser extent the other dopaminergic cell groups. A rise in intracellular calcium concentrations represents one of the final events leading to nerve cell death. Calbindin D28k, a protein capable of buffering intracellular calcium concentrations is present in the dopaminergic neurons that are selectively preserved in PD but not in those that degenerate. To determine whether other calcium-binding proteins also represent putative protective factors of dopaminergic neurons in PD, we analyzed immunohistochemically the distribution of calretinin-containing (CR+) neurons, in the human mesencephalon of three control subjects and four patients with PD
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Pascal:95-0071900Le document en format XML
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<term>Calretinin</term>
<term>Degeneration</term>
<term>Dopaminergic neuron</term>
<term>Human</term>
<term>Neuroprotective agent</term>
<term>Parkinson disease</term>
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<term>Protéine liaison</term>
<term>Neurone dopaminergique</term>
<term>Dégénérescence</term>
<term>Neuroprotecteur</term>
<term>Parkinson maladie</term>
<term>Homme</term>
<term>Calrétinine</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is characterized by a heterogeneous loss of dopaminergic neurons in the human mesencephalon affecting mainly the substantia nigra pars compacta (SNpc) and to a lesser extent the other dopaminergic cell groups. A rise in intracellular calcium concentrations represents one of the final events leading to nerve cell death. Calbindin D28k, a protein capable of buffering intracellular calcium concentrations is present in the dopaminergic neurons that are selectively preserved in PD but not in those that degenerate. To determine whether other calcium-binding proteins also represent putative protective factors of dopaminergic neurons in PD, we analyzed immunohistochemically the distribution of calretinin-containing (CR+) neurons, in the human mesencephalon of three control subjects and four patients with PD</div>
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