Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.
Identifieur interne : 005275 ( Main/Merge ); précédent : 005274; suivant : 005276Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.
Auteurs : J F Démonet [France] ; P. Celsis ; A. Agniel ; D. Cardebat ; O. Rascol ; J P Marc-VergnesSource :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [ 0271-678X ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- diagnostic imaging : Brain.
- physiology : Memory, Mental Recall.
- physiopathology : Parkinson Disease.
- Aged, Analysis of Variance, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Reference Values, Tomography, Emission-Computed, Single-Photon.
Abstract
Task-induced changes in regional cerebral blood flow (rCBF) during memory activation were compared in 18 right-handed patients with early Parkinson's disease (PD) and 20 normal volunteers using the same activation paradigm. We used single-photon emission computed tomography and 133Xe in 21 regions of interest during rest, passive listening of a work list, and memorization of another word list, which was followed by a free recall test immediately after completion of the rCBF measurement. The average performance on free recall was not significantly lower in PD patients than in controls. In normal subjects, five left-sided regions (anterior middle frontal, posterior inferior frontal, superior middle temporal, thalamic, and lenticular) showed a significant increase in memorizing compared to passive listening. This pattern of activation suggests the existence of a verbal rehearsal strategy during the memorization task in normals. In PD patients, increases in these regions did not reach significance, whereas significant activations were noted in superior prefrontal regions. Such alterations in the pattern of activation in PD patients, despite a memory performance similar to that of controls are viewed as a consequence of an early dysfunction of the articulatory loop system and of compensatory mechanisms in other parts of the frontal lobe emerging in the early stages of the disease.
DOI: 10.1038/jcbfm.1994.54
PubMed: 8163585
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001681
- to stream PubMed, to step Curation: 001640
- to stream PubMed, to step Checkpoint: 001640
- to stream Ncbi, to step Merge: 001D32
- to stream Ncbi, to step Curation: 001D32
- to stream Ncbi, to step Checkpoint: 001D32
Links to Exploration step
pubmed:8163585Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.</title><author><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Démonet">J F Démonet</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U 230, Hôpital Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 230, Hôpital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Agniel, A" sort="Agniel, A" uniqKey="Agniel A" first="A" last="Agniel">A. Agniel</name></author><author><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8163585</idno><idno type="pmid">8163585</idno><idno type="doi">10.1038/jcbfm.1994.54</idno><idno type="wicri:Area/PubMed/Corpus">001681</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001681</idno><idno type="wicri:Area/PubMed/Curation">001640</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001640</idno><idno type="wicri:Area/PubMed/Checkpoint">001640</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001640</idno><idno type="wicri:Area/Ncbi/Merge">001D32</idno><idno type="wicri:Area/Ncbi/Curation">001D32</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D32</idno><idno type="wicri:doubleKey">0271-678X:1994:Demonet J:activation:of:regional</idno><idno type="wicri:Area/Main/Merge">005275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.</title><author><name sortKey="Demonet, J F" sort="Demonet, J F" uniqKey="Demonet J" first="J F" last="Démonet">J F Démonet</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U 230, Hôpital Purpan, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 230, Hôpital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Agniel, A" sort="Agniel, A" uniqKey="Agniel A" first="A" last="Agniel">A. Agniel</name></author><author><name sortKey="Cardebat, D" sort="Cardebat, D" uniqKey="Cardebat D" first="D" last="Cardebat">D. Cardebat</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author></analytic><series><title level="j">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</title><idno type="ISSN">0271-678X</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Brain (diagnostic imaging)</term><term>Cerebrovascular Circulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory (physiology)</term><term>Mental Recall (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Reference Values</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term><term>Mental Recall</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Cerebrovascular Circulation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Task-induced changes in regional cerebral blood flow (rCBF) during memory activation were compared in 18 right-handed patients with early Parkinson's disease (PD) and 20 normal volunteers using the same activation paradigm. We used single-photon emission computed tomography and 133Xe in 21 regions of interest during rest, passive listening of a work list, and memorization of another word list, which was followed by a free recall test immediately after completion of the rCBF measurement. The average performance on free recall was not significantly lower in PD patients than in controls. In normal subjects, five left-sided regions (anterior middle frontal, posterior inferior frontal, superior middle temporal, thalamic, and lenticular) showed a significant increase in memorizing compared to passive listening. This pattern of activation suggests the existence of a verbal rehearsal strategy during the memorization task in normals. In PD patients, increases in these regions did not reach significance, whereas significant activations were noted in superior prefrontal regions. Such alterations in the pattern of activation in PD patients, despite a memory performance similar to that of controls are viewed as a consequence of an early dysfunction of the articulatory loop system and of compensatory mechanisms in other parts of the frontal lobe emerging in the early stages of the disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:8163585
|texte= Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:8163585" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |