Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
Identifieur interne : 004A33 ( Main/Merge ); précédent : 004A32; suivant : 004A34Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
Auteurs : E. Bezard [France] ; T. Boraud ; B. Bioulac ; C E GrossSource :
- Neuroscience [ 0306-4522 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Glutamic Acid, Kynurenic Acid.
- drug effects : Substantia Nigra.
- drug therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Macaca.
Abstract
The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human Parkinson's disease. No effects were observed before MPTP treatment or in the first stage of treatment. Once clinical signs appeared, however, motor abnormalities were significantly aggravated by blockage of these inputs (P < 0.001). Conversely, after full Parkinsonism was established, blockage no longer had any behavioural effect. These results confirm the postulated compensatory role of the glutamatergic pathways feeding the substantia nigra pars compacta. This added insight into the physiopathology of the basal ganglia, when compared with previous data on the presymptomatic revelation of experimental Parkinsonism, should help elucidation of the time pattern of evolution of Parkinson's disease.
PubMed: 9300430
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pubmed:9300430Le document en format XML
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Bioulac</name></author><author><name sortKey="Gross, C E" sort="Gross, C E" uniqKey="Gross C" first="C E" last="Gross">C E Gross</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9300430</idno><idno type="pmid">9300430</idno><idno type="wicri:Area/PubMed/Corpus">001509</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001509</idno><idno type="wicri:Area/PubMed/Curation">001468</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001468</idno><idno type="wicri:Area/PubMed/Checkpoint">001468</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001468</idno><idno type="wicri:Area/Ncbi/Merge">001E79</idno><idno type="wicri:Area/Ncbi/Curation">001E79</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E79</idno><idno type="wicri:doubleKey">0306-4522:1997:Bezard E:compensatory:effects:of</idno><idno type="wicri:Area/Main/Merge">004A33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.</title><author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II</wicri:regionArea><wicri:noRegion>Université de Bordeaux II</wicri:noRegion><wicri:noRegion>Université de Bordeaux II</wicri:noRegion></affiliation></author><author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name></author><author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name></author><author><name sortKey="Gross, C E" sort="Gross, C E" uniqKey="Gross C" first="C E" last="Gross">C E Gross</name></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Glutamic Acid (pharmacology)</term><term>Kynurenic Acid (pharmacology)</term><term>Macaca</term><term>Parkinson Disease (drug therapy)</term><term>Substantia Nigra (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glutamic Acid</term><term>Kynurenic Acid</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Macaca</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human Parkinson's disease. No effects were observed before MPTP treatment or in the first stage of treatment. Once clinical signs appeared, however, motor abnormalities were significantly aggravated by blockage of these inputs (P < 0.001). Conversely, after full Parkinsonism was established, blockage no longer had any behavioural effect. These results confirm the postulated compensatory role of the glutamatergic pathways feeding the substantia nigra pars compacta. This added insight into the physiopathology of the basal ganglia, when compared with previous data on the presymptomatic revelation of experimental Parkinsonism, should help elucidation of the time pattern of evolution of Parkinson's disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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