Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.
Identifieur interne : 004355 ( Main/Merge ); précédent : 004354; suivant : 004356Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.
Auteurs : O K Hassani [France] ; J. FégerSource :
- Neuroscience [ 0306-4522 ] ; 1999.
English descriptors
- KwdEn :
- Adrenergic Agents, Animals, Apomorphine (pharmacology), Benzazepines (pharmacology), Dopamine Agonists (pharmacology), Male, Oxidopamine, Parkinson Disease, Proto-Oncogene Proteins c-fos (analysis), Proto-Oncogene Proteins c-fos (drug effects), Quinpirole (pharmacology), Rats, Rats, Sprague-Dawley, Receptors, Dopamine D1 (drug effects), Receptors, Dopamine D1 (physiology), Receptors, Dopamine D2 (drug effects), Receptors, Dopamine D2 (physiology), Substantia Nigra (chemistry), Substantia Nigra (drug effects), Thalamic Nuclei (chemistry), Thalamic Nuclei (drug effects).
- MESH :
- chemical , analysis : Proto-Oncogene Proteins c-fos.
- chemical , drug effects : Proto-Oncogene Proteins c-fos, Receptors, Dopamine D1, Receptors, Dopamine D2.
- chemical , pharmacology : Apomorphine, Benzazepines, Dopamine Agonists, Quinpirole.
- chemical , physiology : Receptors, Dopamine D1, Receptors, Dopamine D2.
- chemical : Adrenergic Agents, Oxidopamine.
- chemistry : Substantia Nigra, Thalamic Nuclei.
- drug effects : Substantia Nigra, Thalamic Nuclei.
- Animals, Male, Parkinson Disease, Rats, Rats, Sprague-Dawley.
Abstract
Subthalamic neuronal activity is controlled by a dopaminergic innervation, which may act via D1 and D2 dopamine receptors. This study investigates the effect of apomorphine and the selective D1 and D2 agonists, SKF 82958 and quinpirole respectively, in normal and 6-hydroxydopamine-lesioned rats. The effect of microinjection of these drugs into the subthalamic nucleus was assessed by recording unit activity and the expression of the c-Fos-immunoreactive protein in the subthalamic nucleus. Dopaminergic agonists reduced the discharge rate and did not induce c-Fos expression in the normal rat. Apomorphine and quinpirole increased the discharge rate and induced a strong expression of c-Fos-like immunoreactive proteins, whereas SKF 82958 induced a decrease of the discharge rate and a slight expression of c-Fos in 6-hydroxydopamine-lesioned rats. The striking contrast in the changes obtained with apomorphine and quinpirole in normal and 6-hydroxydopamine-lesioned rats is discussed in relation to a hyperexpression of D2 dopaminergic receptors on the GABAergic terminals into the subthalamic nucleus. These results show that, in normal rats, dopamine agonists exert an inhibitory control on subthalamic neurons via D1 and D2 receptors. However, in 6-hydroxydopamine-lesioned rats, the hyperactivity of subthalamic neurons is also reduced by D1 receptor agonist but not by D2 dopamine agonists. This last result points out one aspect of the complex mechanisms underlying the physiopathology of Parkinson's disease.
PubMed: 10408602
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001442
- to stream PubMed, to step Curation: 001401
- to stream PubMed, to step Checkpoint: 001401
- to stream Ncbi, to step Merge: 000033
- to stream Ncbi, to step Curation: 000033
- to stream Ncbi, to step Checkpoint: 000033
Links to Exploration step
pubmed:10408602Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.</title><author><name sortKey="Hassani, O K" sort="Hassani, O K" uniqKey="Hassani O" first="O K" last="Hassani">O K Hassani</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie, Faculté de Pharmacie, Université R. Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie, Faculté de Pharmacie, Université R. Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Feger, J" sort="Feger, J" uniqKey="Feger J" first="J" last="Féger">J. Féger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10408602</idno><idno type="pmid">10408602</idno><idno type="wicri:Area/PubMed/Corpus">001442</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001442</idno><idno type="wicri:Area/PubMed/Curation">001401</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001401</idno><idno type="wicri:Area/PubMed/Checkpoint">001401</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001401</idno><idno type="wicri:Area/Ncbi/Merge">000033</idno><idno type="wicri:Area/Ncbi/Curation">000033</idno><idno type="wicri:Area/Ncbi/Checkpoint">000033</idno><idno type="wicri:doubleKey">0306-4522:1999:Hassani O:effects:of:intrasubthalamic</idno><idno type="wicri:Area/Main/Merge">004355</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.</title><author><name sortKey="Hassani, O K" sort="Hassani, O K" uniqKey="Hassani O" first="O K" last="Hassani">O K Hassani</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie, Faculté de Pharmacie, Université R. Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie, Faculté de Pharmacie, Université R. Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Feger, J" sort="Feger, J" uniqKey="Feger J" first="J" last="Féger">J. Féger</name></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic Agents</term><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Benzazepines (pharmacology)</term><term>Dopamine Agonists (pharmacology)</term><term>Male</term><term>Oxidopamine</term><term>Parkinson Disease</term><term>Proto-Oncogene Proteins c-fos (analysis)</term><term>Proto-Oncogene Proteins c-fos (drug effects)</term><term>Quinpirole (pharmacology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Receptors, Dopamine D1 (drug effects)</term><term>Receptors, Dopamine D1 (physiology)</term><term>Receptors, Dopamine D2 (drug effects)</term><term>Receptors, Dopamine D2 (physiology)</term><term>Substantia Nigra (chemistry)</term><term>Substantia Nigra (drug effects)</term><term>Thalamic Nuclei (chemistry)</term><term>Thalamic Nuclei (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proto-Oncogene Proteins c-fos</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Proto-Oncogene Proteins c-fos</term><term>Receptors, Dopamine D1</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term><term>Benzazepines</term><term>Dopamine Agonists</term><term>Quinpirole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine D1</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adrenergic Agents</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Substantia Nigra</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Substantia Nigra</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Parkinson Disease</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic neuronal activity is controlled by a dopaminergic innervation, which may act via D1 and D2 dopamine receptors. This study investigates the effect of apomorphine and the selective D1 and D2 agonists, SKF 82958 and quinpirole respectively, in normal and 6-hydroxydopamine-lesioned rats. The effect of microinjection of these drugs into the subthalamic nucleus was assessed by recording unit activity and the expression of the c-Fos-immunoreactive protein in the subthalamic nucleus. Dopaminergic agonists reduced the discharge rate and did not induce c-Fos expression in the normal rat. Apomorphine and quinpirole increased the discharge rate and induced a strong expression of c-Fos-like immunoreactive proteins, whereas SKF 82958 induced a decrease of the discharge rate and a slight expression of c-Fos in 6-hydroxydopamine-lesioned rats. The striking contrast in the changes obtained with apomorphine and quinpirole in normal and 6-hydroxydopamine-lesioned rats is discussed in relation to a hyperexpression of D2 dopaminergic receptors on the GABAergic terminals into the subthalamic nucleus. These results show that, in normal rats, dopamine agonists exert an inhibitory control on subthalamic neurons via D1 and D2 receptors. However, in 6-hydroxydopamine-lesioned rats, the hyperactivity of subthalamic neurons is also reduced by D1 receptor agonist but not by D2 dopamine agonists. This last result points out one aspect of the complex mechanisms underlying the physiopathology of Parkinson's disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004355 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004355 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:10408602
|texte= Effects of intrasubthalamic injection of dopamine receptor agonists on subthalamic neurons in normal and 6-hydroxydopamine-lesioned rats: an electrophysiological and c-Fos study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:10408602" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |