Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice
Identifieur interne : 004225 ( Main/Merge ); précédent : 004224; suivant : 004226Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice
Auteurs : M. Grandbois [Canada] ; M. Morissette [Canada] ; S. Callier [Canada, France] ; T. Di Paolo [Canada]Source :
- Neuroreport : (Oxford) [ 0959-4965 ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.
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<front><div type="abstract" xml:lang="en">The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.</div>
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