Working memory functioning in medicated Parkinson's disease patients and the effect of withdrawal of dopaminergic medication.
Identifieur interne : 003E70 ( Main/Merge ); précédent : 003E69; suivant : 003E71Working memory functioning in medicated Parkinson's disease patients and the effect of withdrawal of dopaminergic medication.
Auteurs : N. Fournet [France] ; O. Moreaud ; J L Roulin ; B. Naegele ; J. PellatSource :
- Neuropsychology [ 0894-4105 ] ; 2000.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Attention (drug effects), Case-Control Studies, Cognition (drug effects), Dopamine Agents (administration & dosage), Dopamine Agents (adverse effects), Female, Humans, Male, Memory (drug effects), Mental Recall (drug effects), Middle Aged, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (psychology).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Dopamine Agents.
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agents.
- drug effects : Attention, Cognition, Memory, Mental Recall.
- drug therapy : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
Cognitive impairments in Parkinson's disease (PD) could be explained by a central executive (CE) deficit in A. D. Baddeley's (1986) working memory model. To test this hypothesis, verbal, spatial, and double span tasks were given to 12 medicated PD patients and control participants, with varying recall delays. The double span task was assigned to explore the coordinating and integrating function of the CE, and lengthening the recall delay was expected to implicate more attentional resources. PD patients had lower spans relative to controls in all tasks. However, the more specific implication of the CE was difficult to prove. One reason could be that PD patients were on dopaminergic treatment when tested. To control this effect, 12 PD patients on and off medication were studied in a second experiment using the same tasks. PD patients off medication had lower spans only in the double task; this result underlines the role of dopamine on working memory processes.
PubMed: 10791864
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pubmed:10791864Le document en format XML
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Moreaud</name></author><author><name sortKey="Roulin, J L" sort="Roulin, J L" uniqKey="Roulin J" first="J L" last="Roulin">J L Roulin</name></author><author><name sortKey="Naegele, B" sort="Naegele, B" uniqKey="Naegele B" first="B" last="Naegele">B. Naegele</name></author><author><name sortKey="Pellat, J" sort="Pellat, J" uniqKey="Pellat J" first="J" last="Pellat">J. 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Fournet</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Psychologie Expérimentale, Université de Savoie, Chambéry, France. nathalie.fournet@univ-savoie.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Psychologie Expérimentale, Université de Savoie, Chambéry</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Chambéry</settlement></placeName><orgName type="university">Université Savoie Mont Blanc</orgName></affiliation></author><author><name sortKey="Moreaud, O" sort="Moreaud, O" uniqKey="Moreaud O" first="O" last="Moreaud">O. Moreaud</name></author><author><name sortKey="Roulin, J L" sort="Roulin, J L" uniqKey="Roulin J" first="J L" last="Roulin">J L Roulin</name></author><author><name sortKey="Naegele, B" sort="Naegele, B" uniqKey="Naegele B" first="B" last="Naegele">B. Naegele</name></author><author><name sortKey="Pellat, J" sort="Pellat, J" uniqKey="Pellat J" first="J" last="Pellat">J. Pellat</name></author></analytic><series><title level="j">Neuropsychology</title><idno type="ISSN">0894-4105</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Attention (drug effects)</term><term>Case-Control Studies</term><term>Cognition (drug effects)</term><term>Dopamine Agents (administration & dosage)</term><term>Dopamine Agents (adverse effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory (drug effects)</term><term>Mental Recall (drug effects)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Attention</term><term>Cognition</term><term>Memory</term><term>Mental Recall</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive impairments in Parkinson's disease (PD) could be explained by a central executive (CE) deficit in A. D. Baddeley's (1986) working memory model. To test this hypothesis, verbal, spatial, and double span tasks were given to 12 medicated PD patients and control participants, with varying recall delays. The double span task was assigned to explore the coordinating and integrating function of the CE, and lengthening the recall delay was expected to implicate more attentional resources. PD patients had lower spans relative to controls in all tasks. However, the more specific implication of the CE was difficult to prove. One reason could be that PD patients were on dopaminergic treatment when tested. To control this effect, 12 PD patients on and off medication were studied in a second experiment using the same tasks. PD patients off medication had lower spans only in the double task; this result underlines the role of dopamine on working memory processes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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