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Influence of neuromelanin on oxidative pathways within the human substantia nigra

Identifieur interne : 003A51 ( Main/Merge ); précédent : 003A50; suivant : 003A52

Influence of neuromelanin on oxidative pathways within the human substantia nigra

Auteurs : K. L. Double [Australie] ; D. Ben-Shachar [Israël] ; M. B. H. Youdim [Israël] ; L. Zecca [Italie] ; P. Riederer [Allemagne] ; M. Gerlach [Allemagne]

Source :

Neurotoxicology and teratology [ 0892-0362 ] ; 2002.

RBID : Pascal:03-0017999

Descripteurs français

Pascal (Inist)
- Mélanine, Neurone dopaminergique, Locus niger, Parkinson maladie, Homme, Etiologie, Pathogénie, Stress oxydatif.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Dopaminergic neuron, Etiology, Human, Locus niger, Melanin, Oxidative stress, Parkinson disease, Pathogenesis.

Abstract

Neuromelanin (NM) is a dark-coloured pigment produced in the dopaminergic neurons of the human substantia nigra (SN). The function of NM within the pigmented neurons is unknown but other melanins are believed to play a protective role via attenuation of free radical damage. Experimental evidence suggests that NM may also exhibit this characteristic, possibly by directly inactivating free radical species or via its ability to chelate transition metals, such as iron. Increased tissue iron, however, may saturate iron-chelating sites on NM and a looser association between iron and NM may result in an increased, rather than decreased, production of free radical species. The death of NM-pigmented neurons in Parkinson's disease (PD) is associated with both a measurable increase in tissue iron concentrations and indices of free radical mediated damage, suggesting that NM is involved in the aetiology of this disorder. As yet, it is unknown whether NM in the parkinsonian brain differs to that found in healthy tissue and thus may fulfil a different role within this tissue.

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Pascal:03-0017999

Le document en format XML

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<front><div type="abstract" xml:lang="en">Neuromelanin (NM) is a dark-coloured pigment produced in the dopaminergic neurons of the human substantia nigra (SN). The function of NM within the pigmented neurons is unknown but other melanins are believed to play a protective role via attenuation of free radical damage. Experimental evidence suggests that NM may also exhibit this characteristic, possibly by directly inactivating free radical species or via its ability to chelate transition metals, such as iron. Increased tissue iron, however, may saturate iron-chelating sites on NM and a looser association between iron and NM may result in an increased, rather than decreased, production of free radical species. The death of NM-pigmented neurons in Parkinson's disease (PD) is associated with both a measurable increase in tissue iron concentrations and indices of free radical mediated damage, suggesting that NM is involved in the aetiology of this disorder. As yet, it is unknown whether NM in the parkinsonian brain differs to that found in healthy tissue and thus may fulfil a different role within this tissue.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Influence of neuromelanin on oxidative pathways within the human substantia nigra

Influence of neuromelanin on oxidative pathways within the human substantia nigra

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri