ParkinsonFranceV1, Main, Merge, bibRecord, 003415

Role of nigral lesion in the genesis of dyskinesias in a rat model of Parkinson's disease

Identifieur interne : 003415 ( Main/Merge ); précédent : 003414; suivant : 003416

Role of nigral lesion in the genesis of dyskinesias in a rat model of Parkinson's disease

Auteurs : Vincent Paille [France] ; Philippe Brachet [France] ; Philippe Damier [France]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 2004.

RBID : Pascal:04-0446932

Descripteurs français

Pascal (Inist)
- Lésion, Modèle animal, Pathogénie, Lévodopa, Neurone dopaminergique, Mort cellulaire, Oxidopamine, Locus niger, Dyskinésie, Chronique, Mouvement involontaire, Parkinson maladie, Dopamine, Développement, Rat, Homme, Animal, Contrôle moteur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animal, Animal model, Cell death, Chronic, Development, Dopamine, Dopaminergic neuron, Dyskinesia, Human, Involuntary movement, Lesion, Levodopa, Locus niger, Motor control, Oxidopamine, Parkinson disease, Pathogenesis, Rat.

Abstract

The pathogenesis of the motor fluctuations and dyskinesias that complicate levodopa treatment for Parkinson's disease (PD) remains uncertain. To evaluate the relationship between the degree of dopamine neuron loss and the severity of dyskinesias in a rodent model of PD, Sprague-Dawley rats were lesioned unilaterally using different doses of 6-hydroxydopamine injected into the substantia nigra pars compacta (SNc). All rats received two daily oral doses of levodopa for one month. In most of the animals chronic levodopa administration induced abnormal involuntary movements (AIMs), which were in some respects similar to human dyskinesias.We found that a minimum dopamine cell loss of around 95% was required for the development of dyskinesias after one-month of levodopa treatment. Moreover, we observed a positive relationship between the percentage dopaminergic cell loss in the SNc and the severity of levodopa-induced AIMs.

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Pascal:04-0446932

Le document en format XML

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<front><div type="abstract" xml:lang="en">The pathogenesis of the motor fluctuations and dyskinesias that complicate levodopa treatment for Parkinson's disease (PD) remains uncertain. To evaluate the relationship between the degree of dopamine neuron loss and the severity of dyskinesias in a rodent model of PD, Sprague-Dawley rats were lesioned unilaterally using different doses of 6-hydroxydopamine injected into the substantia nigra pars compacta (SNc). All rats received two daily oral doses of levodopa for one month. In most of the animals chronic levodopa administration induced abnormal involuntary movements (AIMs), which were in some respects similar to human dyskinesias.We found that a minimum dopamine cell loss of around 95% was required for the development of dyskinesias after one-month of levodopa treatment. Moreover, we observed a positive relationship between the percentage dopaminergic cell loss in the SNc and the severity of levodopa-induced AIMs.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Role of nigral lesion in the genesis of dyskinesias in a rat model of Parkinson's disease

Role of nigral lesion in the genesis of dyskinesias in a rat model of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri