Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 1993-2003: where are we 10 years on?
Identifieur interne : 003261 ( Main/Merge ); précédent : 003260; suivant : 003262Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 1993-2003: where are we 10 years on?
Auteurs : K. Ashkan [France] ; B. Wallace ; B A Bell ; A L BenabidSource :
- British journal of neurosurgery [ 0268-8697 ] ; 2004.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Basal Ganglia (physiopathology), Dopamine Agents (therapeutic use), Electric Stimulation Therapy, Humans, Levodopa (therapeutic use), Neurosurgical Procedures, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Patient Selection, Postoperative Care (methods), Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Levodopa.
- drug therapy : Parkinson Disease.
- methods : Postoperative Care.
- physiopathology : Basal Ganglia, Parkinson Disease, Subthalamic Nucleus.
- surgery : Parkinson Disease, Subthalamic Nucleus.
- Electric Stimulation Therapy, Humans, Neurosurgical Procedures, Patient Selection.
Abstract
Since its advent in 1993, high frequency stimulation (HFS) of the subthalamic nucleus (STN) has rapidly developed into the most commonly practiced surgical procedure for the treatment of Parkinson's Disease (PD). Although its exact mechanism of action, be it through an inhibitory depolarization block, desynchronization of neuronal circuits or other means, is not clear, the efficacy and safety of the technique are now well established. HFS of the STN improves the motor function by at least 60%, drastically reduces the levodopa requirement and significantly improves the quality of life in PD. This review updates the recent concepts on the pathophysiology of PD and analyses the basic science principles underlying the clinical practice of the STN HFS. The evolution of the surgical technique and long-term patients' outcome are further discussed.
PubMed: 15040711
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pubmed:15040711Le document en format XML
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Wallace</name></author><author><name sortKey="Bell, B A" sort="Bell, B A" uniqKey="Bell B" first="B A" last="Bell">B A Bell</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15040711</idno><idno type="pmid">15040711</idno><idno type="wicri:Area/PubMed/Corpus">001039</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001039</idno><idno type="wicri:Area/PubMed/Curation">000F98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F98</idno><idno type="wicri:Area/PubMed/Checkpoint">000F98</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F98</idno><idno type="wicri:Area/Ncbi/Merge">000431</idno><idno type="wicri:Area/Ncbi/Curation">000431</idno><idno type="wicri:Area/Ncbi/Checkpoint">000431</idno><idno type="wicri:doubleKey">0268-8697:2004:Ashkan K:deep:brain:stimulation</idno><idno type="wicri:Area/Main/Merge">003261</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 1993-2003: where are we 10 years on?</title><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France. kashkan@btinternet.com</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Wallace, B" sort="Wallace, B" uniqKey="Wallace B" first="B" last="Wallace">B. Wallace</name></author><author><name sortKey="Bell, B A" sort="Bell, B A" uniqKey="Bell B" first="B A" last="Bell">B A Bell</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author></analytic><series><title level="j">British journal of neurosurgery</title><idno type="ISSN">0268-8697</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Basal Ganglia (physiopathology)</term><term>Dopamine Agents (therapeutic use)</term><term>Electric Stimulation Therapy</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Neurosurgical Procedures</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Patient Selection</term><term>Postoperative Care (methods)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Postoperative Care</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term><term>Neurosurgical Procedures</term><term>Patient Selection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since its advent in 1993, high frequency stimulation (HFS) of the subthalamic nucleus (STN) has rapidly developed into the most commonly practiced surgical procedure for the treatment of Parkinson's Disease (PD). Although its exact mechanism of action, be it through an inhibitory depolarization block, desynchronization of neuronal circuits or other means, is not clear, the efficacy and safety of the technique are now well established. HFS of the STN improves the motor function by at least 60%, drastically reduces the levodopa requirement and significantly improves the quality of life in PD. This review updates the recent concepts on the pathophysiology of PD and analyses the basic science principles underlying the clinical practice of the STN HFS. The evolution of the surgical technique and long-term patients' outcome are further discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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