Effects of subthalamic nucleus deep brain stimulation and levodopa on energy production rate and substrate oxidation in parkinson's disease
Identifieur interne : 003151 ( Main/Merge ); précédent : 003150; suivant : 003152Effects of subthalamic nucleus deep brain stimulation and levodopa on energy production rate and substrate oxidation in parkinson's disease
Auteurs : Caroline Perlemoine [France] ; Frédéric Macia [France] ; Francois Tison [France] ; Isabelle Coman [France] ; Dominique Guehl [France] ; Pierre Burbaud [France] ; Emmanuel Cuny [France] ; Laurence Baillet [France] ; Henri Gins [France] ; Vincent Rigalleau [France]Source :
- British Journal of Nutrition [ 0007-1145 ] ; 2005.
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Abstract
Patients with Parkinson's disease (PD) often lose weight, but after subthalamic nucleus deep brain stimulation (STN-DBS), they gain weight. We compared daily energy intake (DEI), resting energy expenditure (REE) and substrate oxidation rates (measured by indirect calorimetry) in nineteen STN-DBS-treated patients (Group S), thirteen others on pharmacologic treatment by levodopa (Group L) and eight control subjects. We also determined the acute effects of STN-DBS and levodopa on REE and substrate oxidation rates. STN-DBS treated patients gained 9.7 (SEM 7.1) kg after surgery, whereas patients on pharmacologic treatment lost 3.8 (SEM 10.0) kg since diagnosis. In STN-DBS-treated patients, REE (-16.5%; P<0.001), lipid oxidation (-27%; P<0.05) and protein oxidation (-46 %; P<0.05) were decreased, whereas glucose oxidation was elevated (+81 %; P<0.05) as compared to patients on pharmacologic treatment. Levodopa acutely reduced REE (-8.3%; P<0.05) and glucose oxidation (-37 %; P<0.01) with a slight hyperglycaemic effect (after levodopa challenge: 5.6 (SEM 0.8) v. before levodopa challenge: 5.3 (SEM 0.6) mmol/l; P<0.01). Switching 'on' STN-DBS acutely reduced REE (- 17.5%; P<0.01) and lipid oxidation (-24%; P<0◦.001) 30 min after starting stimulation. Fasting glycaemia was slightly but significantly reduced (5.4 (SEM 1-4) v. 5.5 (SEM 1.3) mmol/1; P<0.01). After STN-DBS, the normalization of REE and the reduction in lipid and protein oxidation contribute to the restoration of weight. As levodopa decreases glucose oxidation, the reduction in daily dose of levodopa in STN-DBS-treated patients helps prevent the effect of weight gain on glycaemia.
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type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Baillet, Laurence" sort="Baillet, Laurence" uniqKey="Baillet L" first="Laurence" last="Baillet">Laurence Baillet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Pessac</settlement></placeName></affiliation></author><author><name sortKey="Gins, Henri" sort="Gins, Henri" uniqKey="Gins H" first="Henri" last="Gins">Henri Gins</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 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Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Pessac</settlement></placeName></affiliation></author><author><name sortKey="Macia, Frederic" sort="Macia, Frederic" uniqKey="Macia F" first="Frédéric" last="Macia">Frédéric Macia</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Lévêque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Lévêque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Coman, Isabelle" sort="Coman, Isabelle" uniqKey="Coman I" first="Isabelle" last="Coman">Isabelle Coman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Lévêque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Lévêque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Service de Neurologie, Hôpital Haut-Lévêque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Lévêque</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Service de Neurochirurgie, Hôpital du Tripode</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Baillet, Laurence" sort="Baillet, Laurence" uniqKey="Baillet L" first="Laurence" last="Baillet">Laurence Baillet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Pessac</settlement></placeName></affiliation></author><author><name sortKey="Gins, Henri" sort="Gins, Henri" uniqKey="Gins H" first="Henri" last="Gins">Henri Gins</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Pessac</settlement></placeName></affiliation></author><author><name sortKey="Rigalleau, Vincent" sort="Rigalleau, Vincent" uniqKey="Rigalleau V" first="Vincent" last="Rigalleau">Vincent Rigalleau</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue Magellan</s1><s2>33600 Pessac</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Pessac</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">British Journal of Nutrition</title><title level="j" type="abbreviated">Br. J. Nutr.</title><idno type="ISSN">0007-1145</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British Journal of Nutrition</title><title level="j" type="abbreviated">Br. J. Nutr.</title><idno type="ISSN">0007-1145</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Change</term><term>Diet</term><term>Energetic cost</term><term>Energy</term><term>Mammalia</term><term>Oxidation</term><term>Parkinson disease</term><term>Production rate</term><term>Substrate</term><term>Subthalamic nucleus</term><term>Thermogenesis</term><term>Weight</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Noyau sousthalamique</term><term>Energie</term><term>Taux production</term><term>Substrat</term><term>Oxydation</term><term>Dépense énergétique</term><term>Poids</term><term>Changement</term><term>Parkinson maladie</term><term>Régime alimentaire</term><term>Thermogenèse</term><term>Mammalia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) often lose weight, but after subthalamic nucleus deep brain stimulation (STN-DBS), they gain weight. We compared daily energy intake (DEI), resting energy expenditure (REE) and substrate oxidation rates (measured by indirect calorimetry) in nineteen STN-DBS-treated patients (Group S), thirteen others on pharmacologic treatment by levodopa (Group L) and eight control subjects. We also determined the acute effects of STN-DBS and levodopa on REE and substrate oxidation rates. STN-DBS treated patients gained 9.7 (SEM 7.1) kg after surgery, whereas patients on pharmacologic treatment lost 3.8 (SEM 10.0) kg since diagnosis. In STN-DBS-treated patients, REE (-16.5%; P<0.001), lipid oxidation (-27%; P<0.05) and protein oxidation (-46 %; P<0.05) were decreased, whereas glucose oxidation was elevated (+81 %; P<0.05) as compared to patients on pharmacologic treatment. Levodopa acutely reduced REE (-8.3%; P<0.05) and glucose oxidation (-37 %; P<0.01) with a slight hyperglycaemic effect (after levodopa challenge: 5.6 (SEM 0.8) v. before levodopa challenge: 5.3 (SEM 0.6) mmol/l; P<0.01). Switching 'on' STN-DBS acutely reduced REE (- 17.5%; P<0.01) and lipid oxidation (-24%; P<0◦.001) 30 min after starting stimulation. Fasting glycaemia was slightly but significantly reduced (5.4 (SEM 1-4) v. 5.5 (SEM 1.3) mmol/1; P<0.01). After STN-DBS, the normalization of REE and the reduction in lipid and protein oxidation contribute to the restoration of weight. As levodopa decreases glucose oxidation, the reduction in daily dose of levodopa in STN-DBS-treated patients helps prevent the effect of weight gain on glycaemia.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li><li>Pessac</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Perlemoine, Caroline" sort="Perlemoine, Caroline" uniqKey="Perlemoine C" first="Caroline" last="Perlemoine">Caroline Perlemoine</name></region><name sortKey="Baillet, Laurence" sort="Baillet, Laurence" uniqKey="Baillet L" first="Laurence" last="Baillet">Laurence Baillet</name><name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name><name sortKey="Coman, Isabelle" sort="Coman, Isabelle" uniqKey="Coman I" first="Isabelle" last="Coman">Isabelle Coman</name><name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name><name sortKey="Gins, Henri" sort="Gins, Henri" uniqKey="Gins H" first="Henri" last="Gins">Henri Gins</name><name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name><name sortKey="Macia, Frederic" sort="Macia, Frederic" uniqKey="Macia F" first="Frédéric" last="Macia">Frédéric Macia</name><name sortKey="Rigalleau, Vincent" sort="Rigalleau, Vincent" uniqKey="Rigalleau V" first="Vincent" last="Rigalleau">Vincent Rigalleau</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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