Only physical aspects of quality of life are significantly improved by bilateral subthalamic stimulation in Parkinson's disease
Identifieur interne : 003131 ( Main/Merge ); précédent : 003130; suivant : 003132Only physical aspects of quality of life are significantly improved by bilateral subthalamic stimulation in Parkinson's disease
Auteurs : Sophie Drapier [France] ; Sylvie Raoul [France] ; Dominique Drapier [France] ; Emmanuelle Leray [France] ; Francois Lallement [France] ; Isabelle Rivier [France] ; Paul Sauleau [France] ; Youen Lajat [France] ; Gilles Edan [France] ; Marc Verin [France]Source :
- Journal of neurology [ 0340-5354 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background The well known global improvement of quality of life (QoL) after bilateral high frequency chronic deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) is in contrast to behavioral disturbances as observed after surgery. Indeed the impact of DBS on physical versus mental aspects of QoL in PD remains unknown. Objective To assess the influence of bilateral STN DBS on physical versus mental aspects of QoL in Parkinson's disease. Methods The results of 27 patients for the Unified Parkinson's disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire 39 (PDQ39) and Short Form 36 health survey questionnaire (SF36) were compared before surgery and after 12 months of bilateral STN DBS. Results Comparing off-dopa conditions before versus 12 months after surgery, both UPDRS part II and part III significantly improved: 32.6 % and 52%, respectively. UPDRS part I scores did not change significantly at 12 months. As for PDQ39, the global score significantly improved after surgery (21.1 %) as did four subscores: mobility (25.6 %), activity of daily living (34.5 %), stigma (40.1 %) and bodily discomfort (30%). Three PDQ39 subscores, however, showed no significant changes: emotional well-being (10.7%), social support (3.2%) and cognition (8.5%) and one item even worsened: communication (-7.7%). In SF36, only physical items significantly improved. Conclusion Using clinician's based rating scale, bilateral STN DBS showed significant improvement in PD patients at 12 month follow up. However, using patient's self-assessment scales, the clinical benefit of STN DBS was more subtle: physical items of QoL significantly improved, whereas mental items such as emotional well-being, social support, cognition and communication showed no improvement. Our results are suggestive of a dissociation of motor and non-motor symptoms control after bilateral STN DBS in PD patients.
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<series><title level="j" type="main">Journal of neurology</title>
<title level="j" type="abbreviated">J. neurol.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Quality of life</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Qualité vie</term>
<term>Noyau sousthalamique</term>
<term>Parkinson maladie</term>
<term>Stimulation cérébrale profonde</term>
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<front><div type="abstract" xml:lang="en">Background The well known global improvement of quality of life (QoL) after bilateral high frequency chronic deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) is in contrast to behavioral disturbances as observed after surgery. Indeed the impact of DBS on physical versus mental aspects of QoL in PD remains unknown. Objective To assess the influence of bilateral STN DBS on physical versus mental aspects of QoL in Parkinson's disease. Methods The results of 27 patients for the Unified Parkinson's disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire 39 (PDQ39) and Short Form 36 health survey questionnaire (SF36) were compared before surgery and after 12 months of bilateral STN DBS. Results Comparing off-dopa conditions before versus 12 months after surgery, both UPDRS part II and part III significantly improved: 32.6 % and 52%, respectively. UPDRS part I scores did not change significantly at 12 months. As for PDQ39, the global score significantly improved after surgery (21.1 %) as did four subscores: mobility (25.6 %), activity of daily living (34.5 %), stigma (40.1 %) and bodily discomfort (30%). Three PDQ39 subscores, however, showed no significant changes: emotional well-being (10.7%), social support (3.2%) and cognition (8.5%) and one item even worsened: communication (-7.7%). In SF36, only physical items significantly improved. Conclusion Using clinician's based rating scale, bilateral STN DBS showed significant improvement in PD patients at 12 month follow up. However, using patient's self-assessment scales, the clinical benefit of STN DBS was more subtle: physical items of QoL significantly improved, whereas mental items such as emotional well-being, social support, cognition and communication showed no improvement. Our results are suggestive of a dissociation of motor and non-motor symptoms control after bilateral STN DBS in PD patients.</div>
</front>
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<tree><country name="France"><region name="Région Bretagne"><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
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<name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
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<name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
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