La maladie de Parkinson en France (serveur d'exploration)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

Identifieur interne : 002F91 ( Main/Merge ); précédent : 002F90; suivant : 002F92

Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies

Auteurs : Urs P. Mosimann ; Rene M. Mu Ri [Suisse] ; David J. Burn ; Jacques Felblinger [France] ; John T. O'Brien ; Ian G. Mckeith

Source :

RBID : ISTEX:968A6B8A1F44AEB64770D967DD2708FF6D288FFA

English descriptors

Abstract

Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.

Url:
DOI: 10.1093/brain/awh484

Links toward previous steps (curation, corpus...)


Links to Exploration step

ISTEX:968A6B8A1F44AEB64770D967DD2708FF6D288FFA

Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies</title>
<author>
<name sortKey="Mosimann, Urs P" sort="Mosimann, Urs P" uniqKey="Mosimann U" first="Urs P." last="Mosimann">Urs P. Mosimann</name>
</author>
<author>
<name sortKey="Mu Ri, Rene M" sort="Mu Ri, Rene M" uniqKey="Mu Ri R" first="Rene M." last="Mu Ri">Rene M. Mu Ri</name>
</author>
<author>
<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
</author>
<author>
<name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name>
</author>
<author>
<name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G." last="Mckeith">Ian G. Mckeith</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:968A6B8A1F44AEB64770D967DD2708FF6D288FFA</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1093/brain/awh484</idno>
<idno type="url">https://api.istex.fr/document/968A6B8A1F44AEB64770D967DD2708FF6D288FFA/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002488</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002488</idno>
<idno type="wicri:Area/Istex/Curation">002486</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A83</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A83</idno>
<idno type="wicri:doubleKey">0006-8950:2005:Mosimann U:saccadic:eye:movement</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00620096</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00620096</idno>
<idno type="wicri:Area/Hal/Corpus">000984</idno>
<idno type="wicri:Area/Hal/Curation">000984</idno>
<idno type="wicri:Area/Hal/Checkpoint">000A90</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000A90</idno>
<idno type="wicri:doubleKey">0006-8950:2005:Mosimann U:saccadic:eye:movement</idno>
<idno type="wicri:Area/Main/Merge">002F91</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies</title>
<author>
<name sortKey="Mosimann, Urs P" sort="Mosimann, Urs P" uniqKey="Mosimann U" first="Urs P." last="Mosimann">Urs P. Mosimann</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Mu Ri, Rene M" sort="Mu Ri, Rene M" uniqKey="Mu Ri R" first="Rene M." last="Mu Ri">Rene M. Mu Ri</name>
<affiliation wicri:level="3">
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author>
<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
<affiliation wicri:level="1">
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, University Hospital of Nancy, Vandoeuvre</wicri:regionArea>
<wicri:noRegion>Vandoeuvre</wicri:noRegion>
<wicri:noRegion>Vandoeuvre</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
</author>
<author>
<name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G." last="Mckeith">Ian G. Mckeith</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Brain</title>
<title level="j" type="abbrev">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint>
<publisher>Oxford University Press</publisher>
<date type="published" when="2005-06">2005-06</date>
<biblScope unit="volume">128</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1267">1267</biblScope>
<biblScope unit="page" to="1276">1276</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">968A6B8A1F44AEB64770D967DD2708FF6D288FFA</idno>
<idno type="DOI">10.1093/brain/awh484</idno>
<idno type="local">awh484</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>ANOVA = analysis of variance</term>
<term>Alzheimer's disease</term>
<term>CS = central stimulus</term>
<term>DLB = dementia with Lewy bodies</term>
<term>PDD = Parkinson's disease dementia</term>
<term>Parkinson's disease dementia</term>
<term>dementia with Lewy bodies</term>
<term>saccades</term>
</keywords>
<keywords scheme="mix" xml:lang="en">
<term>Alzheimer's disease</term>
<term>Parkinson's disease dementia</term>
<term>dementia with Lewy bodies</term>
<term>saccades</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.</div>
</front>
</TEI>
<double doi="10.1093/brain/awh484">
<HAL>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies.</title>
<author>
<name sortKey="Mosimann, Urs" sort="Mosimann, Urs" uniqKey="Mosimann U" first="Urs" last="Mosimann">Urs Mosimann</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Muri, Rene" sort="Muri, Rene" uniqKey="Muri R" first="René" last="Müri">René Müri</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167360" status="INCOMING">
<orgName>Perception and Eye Movement Laboratory</orgName>
<desc>
<address>
<country key="CH"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-312897" type="direct"></relation>
<relation active="#struct-342488" type="direct"></relation>
<relation active="#struct-342489" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-312897" type="direct">
<org type="institution" xml:id="struct-312897" status="INCOMING">
<orgName>Inselspital, Bern</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342488" type="direct">
<org type="institution" xml:id="struct-342488" status="INCOMING">
<orgName>Departments of Neurology</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342489" type="direct">
<org type="institution" xml:id="struct-342489" status="INCOMING">
<orgName>Clinical Research</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author>
<name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167361" status="INCOMING">
<orgName>Department of Radiology</orgName>
<desc>
<address>
<addrLine>Vandoeuvre</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-300157" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-300157" type="direct">
<org type="institution" xml:id="struct-300157" status="VALID">
<orgName>CHU Nancy</orgName>
<desc>
<address>
<addrLine>29, avenue du Maréchal de Lattre de Tassigny, 54035 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-nancy.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author>
<name sortKey="O Brien, John" sort="O Brien, John" uniqKey="O Brien J" first="John" last="O'Brien">John O'Brien</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Mckeith, Ian" sort="Mckeith, Ian" uniqKey="Mckeith I" first="Ian" last="Mckeith">Ian Mckeith</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00620096</idno>
<idno type="halId">inserm-00620096</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00620096</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00620096</idno>
<idno type="doi">10.1093/brain/awh484</idno>
<date when="2005-06">2005-06</date>
<idno type="wicri:Area/Hal/Corpus">000984</idno>
<idno type="wicri:Area/Hal/Curation">000984</idno>
<idno type="wicri:Area/Hal/Checkpoint">000A90</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000A90</idno>
<idno type="wicri:doubleKey">0006-8950:2005:Mosimann U:saccadic:eye:movement</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies.</title>
<author>
<name sortKey="Mosimann, Urs" sort="Mosimann, Urs" uniqKey="Mosimann U" first="Urs" last="Mosimann">Urs Mosimann</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Muri, Rene" sort="Muri, Rene" uniqKey="Muri R" first="René" last="Müri">René Müri</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167360" status="INCOMING">
<orgName>Perception and Eye Movement Laboratory</orgName>
<desc>
<address>
<country key="CH"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-312897" type="direct"></relation>
<relation active="#struct-342488" type="direct"></relation>
<relation active="#struct-342489" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-312897" type="direct">
<org type="institution" xml:id="struct-312897" status="INCOMING">
<orgName>Inselspital, Bern</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342488" type="direct">
<org type="institution" xml:id="struct-342488" status="INCOMING">
<orgName>Departments of Neurology</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342489" type="direct">
<org type="institution" xml:id="struct-342489" status="INCOMING">
<orgName>Clinical Research</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Suisse</country>
</affiliation>
</author>
<author>
<name sortKey="Burn, David" sort="Burn, David" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167361" status="INCOMING">
<orgName>Department of Radiology</orgName>
<desc>
<address>
<addrLine>Vandoeuvre</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-300157" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-300157" type="direct">
<org type="institution" xml:id="struct-300157" status="VALID">
<orgName>CHU Nancy</orgName>
<desc>
<address>
<addrLine>29, avenue du Maréchal de Lattre de Tassigny, 54035 Nancy cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-nancy.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author>
<name sortKey="O Brien, John" sort="O Brien, John" uniqKey="O Brien J" first="John" last="O'Brien">John O'Brien</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author>
<name sortKey="Mckeith, Ian" sort="Mckeith, Ian" uniqKey="Mckeith I" first="Ian" last="Mckeith">Ian Mckeith</name>
<affiliation wicri:level="1">
<hal:affiliation type="laboratory" xml:id="struct-167359" status="INCOMING">
<orgName>Institute for Ageing and Health</orgName>
<desc>
<address>
<country key="GB"></country>
</address>
</desc>
<listRelation>
<relation active="#struct-322926" type="direct"></relation>
<relation active="#struct-342426" type="direct"></relation>
</listRelation>
<tutelles>
<tutelle active="#struct-322926" type="direct">
<org type="institution" xml:id="struct-322926" status="INCOMING">
<orgName>Newcastle General Hospital</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-342426" type="direct">
<org type="institution" xml:id="struct-342426" status="INCOMING">
<orgName>Newcastle upon Tyne</orgName>
<desc>
<address>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1093/brain/awh484</idno>
<series>
<title level="j">Brain - A Journal of Neurology </title>
<idno type="ISSN">0006-8950</idno>
<imprint>
<date type="datePub">2005-06</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="mix" xml:lang="en">
<term>Alzheimer's disease</term>
<term>Parkinson's disease dementia</term>
<term>dementia with Lewy bodies</term>
<term>saccades</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity > or =60%, specificity > or =77%) and between PDD versus Parkinson's disease (sensitivity > or =60%, specificity > or =88%) when +/-1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.</div>
</front>
</TEI>
</HAL>
<ISTEX>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies</title>
<author>
<name sortKey="Mosimann, Urs P" sort="Mosimann, Urs P" uniqKey="Mosimann U" first="Urs P." last="Mosimann">Urs P. Mosimann</name>
</author>
<author>
<name sortKey="Mu Ri, Rene M" sort="Mu Ri, Rene M" uniqKey="Mu Ri R" first="Rene M." last="Mu Ri">Rene M. Mu Ri</name>
</author>
<author>
<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
</author>
<author>
<name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name>
</author>
<author>
<name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G." last="Mckeith">Ian G. Mckeith</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:968A6B8A1F44AEB64770D967DD2708FF6D288FFA</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1093/brain/awh484</idno>
<idno type="url">https://api.istex.fr/document/968A6B8A1F44AEB64770D967DD2708FF6D288FFA/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002488</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002488</idno>
<idno type="wicri:Area/Istex/Curation">002486</idno>
<idno type="wicri:Area/Istex/Checkpoint">000A83</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A83</idno>
<idno type="wicri:doubleKey">0006-8950:2005:Mosimann U:saccadic:eye:movement</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies</title>
<author>
<name sortKey="Mosimann, Urs P" sort="Mosimann, Urs P" uniqKey="Mosimann U" first="Urs P." last="Mosimann">Urs P. Mosimann</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Mu Ri, Rene M" sort="Mu Ri, Rene M" uniqKey="Mu Ri R" first="Rene M." last="Mu Ri">Rene M. Mu Ri</name>
<affiliation wicri:level="3">
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Perception and Eye Movement Laboratory, Departments of Neurology and Clinical Research, Inselspital, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author>
<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Felblinger, Jacques" sort="Felblinger, Jacques" uniqKey="Felblinger J" first="Jacques" last="Felblinger">Jacques Felblinger</name>
<affiliation wicri:level="1">
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, University Hospital of Nancy, Vandoeuvre</wicri:regionArea>
<wicri:noRegion>Vandoeuvre</wicri:noRegion>
<wicri:noRegion>Vandoeuvre</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
</author>
<author>
<name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Mckeith, Ian G" sort="Mckeith, Ian G" uniqKey="Mckeith I" first="Ian G." last="Mckeith">Ian G. Mckeith</name>
<affiliation></affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Brain</title>
<title level="j" type="abbrev">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint>
<publisher>Oxford University Press</publisher>
<date type="published" when="2005-06">2005-06</date>
<biblScope unit="volume">128</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1267">1267</biblScope>
<biblScope unit="page" to="1276">1276</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">968A6B8A1F44AEB64770D967DD2708FF6D288FFA</idno>
<idno type="DOI">10.1093/brain/awh484</idno>
<idno type="local">awh484</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>ANOVA = analysis of variance</term>
<term>Alzheimer's disease</term>
<term>CS = central stimulus</term>
<term>DLB = dementia with Lewy bodies</term>
<term>PDD = Parkinson's disease dementia</term>
<term>Parkinson's disease dementia</term>
<term>dementia with Lewy bodies</term>
<term>saccades</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Neurodegeneration in Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) affect cortical and subcortical networks involved in saccade generation. We therefore expected impairments in saccade performance in both disorders. In order to improve the pathophysiological understanding and to investigate the usefulness of saccades for differential diagnosis, saccades were tested in age- and education-matched patients with PDD (n = 20) and DLB (n = 20), Alzheimer's disease (n = 22) and Parkinson's disease (n = 24), and controls (n = 24). Reflexive (gap, overlap) and complex saccades (prediction, decision and antisaccade) were tested with electro-oculography. PDD and DLB patients had similar impairment in all tasks (P > 0.05, not significant). Compared with controls, they were impaired in both reflexive saccade execution (gap and overlap latencies, P < 0.0001; gains, P < 0.004) and complex saccade performance (target prediction, P < 0.0001; error decisions, P < 0.003; error antisaccades: P < 0.0001). Patients with Alzheimer's disease were only impaired in complex saccade performance (Alzheimer's disease versus controls, target prediction P < 0.001, error decisions P < 0.0001, error antisaccades P < 0.0001), but not reflexive saccade execution (for all, P > 0.05). Patients with Parkinson's disease had, compared with controls, similar complex saccade performance (for all, P > 0.05) and only minimal impairment in reflexive tasks, i.e. hypometric gain in the gap task (P = 0.04). Impaired saccade execution in reflexive tasks allowed discrimination between DLB versus Alzheimer's disease (sensitivity ≥60%, specificity ≥77%) and between PDD versus Parkinson's disease (sensitivity ≥60%, specificity ≥88%) when ±1.5 standard deviations was used for group discrimination. We conclude that impairments in reflexive saccades may be helpful for differential diagnosis and are minimal when either cortical (Alzheimer's disease) or nigrostriatal neurodegeneration (Parkinson's disease) exists solely; however, they become prominent with combined cortical and subcortical neurodegeneration in PDD and DLB. The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F91 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002F91 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:968A6B8A1F44AEB64770D967DD2708FF6D288FFA
   |texte=   Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
}}

Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024