Abnormal cortical mechanisms in voluntary muscle relaxation in de novo parkinsonian patients.
Identifieur interne : 002F60 ( Main/Merge ); précédent : 002F59; suivant : 002F61Abnormal cortical mechanisms in voluntary muscle relaxation in de novo parkinsonian patients.
Auteurs : Etienne Labyt [France] ; François Cassim ; David Devos ; Jean-Louis Bourriez ; Alain Destée [France] ; Jean-Daiel Guieu ; Luc Defebvre [France] ; Philippe DerambureSource :
- Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society [ 0736-0258 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Aged, Brain Mapping, Case-Control Studies, Cortical Synchronization, Electroencephalography (methods), Electromyography (methods), Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Motor Cortex (pathology), Motor Cortex (physiopathology), Movement (physiology), Muscle Contraction (physiology), Muscle Relaxation (physiology), Muscle, Skeletal (physiopathology), Parkinson Disease (physiopathology), Reference Values, Statistics, Nonparametric, Time Factors.
- MESH :
- methods : Electroencephalography, Electromyography.
- pathology : Motor Cortex.
- physiology : Evoked Potentials, Movement, Muscle Contraction, Muscle Relaxation.
- physiopathology : Motor Cortex, Muscle, Skeletal, Parkinson Disease.
- Adult, Aged, Brain Mapping, Case-Control Studies, Cortical Synchronization, Female, Humans, Male, Middle Aged, Reference Values, Statistics, Nonparametric, Time Factors.
Abstract
This study aimed at elucidating how the cortical mechanism underlying the preparation and the postmovement phase of voluntary hand muscle relaxation is affected in Parkinson's disease. Event-related mu and beta (de)synchronization (ERD/S) related to voluntary muscle contraction and relaxation were recorded in 16 untreated, akineto-rigid, predominantly hemiparkinsonian patients. The results were compared with data from 10 age-matched, healthy subjects. In the muscle relaxation task, the subject held the wrist in an extended position and then let the hand drop by voluntarily relaxing wrist extensor contraction, i.e., without any overt, associated muscle contraction. In the muscle contraction task, subjects performed a self-initiated brief wrist extension. A same pattern of ERD/S was observed in control subjects and parkinsonian patients performing the motor tasks with their less affected limb. In contrast, related to voluntary relaxation performed with the more affected limb, a delayed mu and beta ERD and a disappearance of beta ERS were revealed. These results demonstrate that the pattern of cortical oscillatory activity in a relaxation task is abnormal in parkinsonian patients. The authors suggest that this may be due to anomalous activity in inhibitory motor cortical systems and impaired sensorimotor integration of afferent inputs from muscle and joint receptors.
PubMed: 15933492
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Salengro Hospital, Lille University Medical Center, Lille Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Neurophysiology, R. Salengro Hospital, Lille University Medical Center, Lille Cedex</wicri:regionArea><wicri:noRegion>Lille Cedex</wicri:noRegion><wicri:noRegion>Lille Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Cassim, Francois" sort="Cassim, Francois" uniqKey="Cassim F" first="François" last="Cassim">François Cassim</name></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name></author><author><name sortKey="Bourriez, Jean Louis" sort="Bourriez, Jean Louis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Guieu, Jean Daiel" sort="Guieu, Jean Daiel" uniqKey="Guieu J" first="Jean-Daiel" last="Guieu">Jean-Daiel Guieu</name></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Derambure, Philippe" sort="Derambure, Philippe" uniqKey="Derambure P" first="Philippe" last="Derambure">Philippe Derambure</name></author></analytic><series><title level="j">Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society</title><idno type="ISSN">0736-0258</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Cortical Synchronization</term><term>Electroencephalography (methods)</term><term>Electromyography (methods)</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (pathology)</term><term>Motor Cortex (physiopathology)</term><term>Movement (physiology)</term><term>Muscle Contraction (physiology)</term><term>Muscle Relaxation (physiology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Parkinson Disease (physiopathology)</term><term>Reference Values</term><term>Statistics, Nonparametric</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electroencephalography</term><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials</term><term>Movement</term><term>Muscle Contraction</term><term>Muscle Relaxation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Muscle, Skeletal</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Cortical Synchronization</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Statistics, Nonparametric</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aimed at elucidating how the cortical mechanism underlying the preparation and the postmovement phase of voluntary hand muscle relaxation is affected in Parkinson's disease. Event-related mu and beta (de)synchronization (ERD/S) related to voluntary muscle contraction and relaxation were recorded in 16 untreated, akineto-rigid, predominantly hemiparkinsonian patients. The results were compared with data from 10 age-matched, healthy subjects. In the muscle relaxation task, the subject held the wrist in an extended position and then let the hand drop by voluntarily relaxing wrist extensor contraction, i.e., without any overt, associated muscle contraction. In the muscle contraction task, subjects performed a self-initiated brief wrist extension. A same pattern of ERD/S was observed in control subjects and parkinsonian patients performing the motor tasks with their less affected limb. In contrast, related to voluntary relaxation performed with the more affected limb, a delayed mu and beta ERD and a disappearance of beta ERS were revealed. These results demonstrate that the pattern of cortical oscillatory activity in a relaxation task is abnormal in parkinsonian patients. The authors suggest that this may be due to anomalous activity in inhibitory motor cortical systems and impaired sensorimotor integration of afferent inputs from muscle and joint receptors.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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