Subthalamic nucleus influences spatial orientation in extrapersonal space
Identifieur interne : 002E13 ( Main/Merge ); précédent : 002E12; suivant : 002E14Subthalamic nucleus influences spatial orientation in extrapersonal space
Auteurs : Karsten Witt [Allemagne] ; Florian Kopper [Allemagne] ; Günther Deuschl [Allemagne] ; Paul Krack [France]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined I year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.
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Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0208443</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0208443 INIST</idno><idno type="RBID">Pascal:06-0208443</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B81</idno><idno type="wicri:Area/PascalFrancis/Curation">000853</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000973</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000973</idno><idno type="wicri:doubleKey">0885-3185:2006:Witt K:subthalamic:nucleus:influences</idno><idno type="wicri:Area/Main/Merge">002E13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic nucleus influences spatial orientation in extrapersonal space</title><author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Schleswig -Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Schleswig -Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Schleswig -Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Nervous system diseases</term><term>Spatial orientation</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Noyau sousthalamique</term><term>Orientation spatiale</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined I year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Schleswig-Holstein</li></region><settlement><li>Grenoble</li><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name></region><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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