Camptocormia and Parkinson's disease: MR imaging.
Identifieur interne : 002528 ( Main/Merge ); précédent : 002527; suivant : 002529Camptocormia and Parkinson's disease: MR imaging.
Auteurs : Fabrice Bonneville [France] ; Frédéric Bloch ; Ewa Kurys ; Sophie Tezenas Du Montcel ; Marie-Laure Welter ; Anne-Marie Bonnet ; Yves Agid [France] ; Didier Dormont ; Jean-Luc HouetoSource :
- European radiology [ 0938-7994 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease, Spinal Curvatures.
- pathology : Atrophy, Brain, Parkinson Disease, Spinal Curvatures.
- Aged, Humans, Magnetic Resonance Imaging, Male, Organ Size.
Abstract
Camptocormia is characterized by an excessive anterior flexion of the spine that appears only when standing or walking. The origin of this symptom remains unknown, but recent clinical reports of camptocormia associated with Parkinson's disease (PD) suggest cerebral involvement in the pathogenesis of camptocormia. This study was undertaken to investigate the hypothesis that camptocormia in PD has a central origin. Seventeen PD patients with camptocormia were prospectively enrolled and were compared to 10 matched PD patients without camptocormia and 12 normal controls. The normalized volumes of the brain, striatal nuclei, and the cross-sectional areas of the midbrain and pons were measured on three-dimensional magnetic resonance imaging. Data were correlated with the severity of the symptoms. The normalized axial surface of the midbrain was statistically smaller in PD patients with camptocormia than in normal controls (P = 0.01). The normalized volumetric data were not statistically different in PD patients with camptocormia. There was a significant negative correlation between the severity of camptocormia and the normalized brain volume (P < 0.009; R = -0.649) and sagittal pons area (P < 0.01; R = -0.642). The results suggest that PD with camptocormia may represent a selective form of PD in which a specific neuronal dysfunction possibly occurs within the brainstem.
DOI: 10.1007/s00330-008-0927-8
PubMed: 18351343
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000C70
- to stream PubMed, to step Curation: 000C30
- to stream PubMed, to step Checkpoint: 000C30
- to stream Ncbi, to step Merge: 000827
- to stream Ncbi, to step Curation: 000827
- to stream Ncbi, to step Checkpoint: 000827
Links to Exploration step
pubmed:18351343Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Camptocormia and Parkinson's disease: MR imaging.</title><author><name sortKey="Bonneville, Fabrice" sort="Bonneville, Fabrice" uniqKey="Bonneville F" first="Fabrice" last="Bonneville">Fabrice Bonneville</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neuroradiologie, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France. fabrice.bonneville@psl.aphp.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neuroradiologie, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name></author><author><name sortKey="Kurys, Ewa" sort="Kurys, Ewa" uniqKey="Kurys E" first="Ewa" last="Kurys">Ewa Kurys</name></author><author><name sortKey="Du Montcel, Sophie Tezenas" sort="Du Montcel, Sophie Tezenas" uniqKey="Du Montcel S" first="Sophie Tezenas" last="Du Montcel">Sophie Tezenas Du Montcel</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18351343</idno><idno type="pmid">18351343</idno><idno type="doi">10.1007/s00330-008-0927-8</idno><idno type="wicri:Area/PubMed/Corpus">000C70</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C70</idno><idno type="wicri:Area/PubMed/Curation">000C30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C30</idno><idno type="wicri:Area/PubMed/Checkpoint">000C30</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C30</idno><idno type="wicri:Area/Ncbi/Merge">000827</idno><idno type="wicri:Area/Ncbi/Curation">000827</idno><idno type="wicri:Area/Ncbi/Checkpoint">000827</idno><idno type="wicri:doubleKey">0938-7994:2008:Bonneville F:camptocormia:and:parkinson</idno><idno type="wicri:Area/Main/Merge">002528</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Camptocormia and Parkinson's disease: MR imaging.</title><author><name sortKey="Bonneville, Fabrice" sort="Bonneville, Fabrice" uniqKey="Bonneville F" first="Fabrice" last="Bonneville">Fabrice Bonneville</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neuroradiologie, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France. fabrice.bonneville@psl.aphp.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neuroradiologie, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bloch, Frederic" sort="Bloch, Frederic" uniqKey="Bloch F" first="Frédéric" last="Bloch">Frédéric Bloch</name></author><author><name sortKey="Kurys, Ewa" sort="Kurys, Ewa" uniqKey="Kurys E" first="Ewa" last="Kurys">Ewa Kurys</name></author><author><name sortKey="Du Montcel, Sophie Tezenas" sort="Du Montcel, Sophie Tezenas" uniqKey="Du Montcel S" first="Sophie Tezenas" last="Du Montcel">Sophie Tezenas Du Montcel</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author></analytic><series><title level="j">European radiology</title><idno type="ISSN">0938-7994</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Atrophy (pathology)</term><term>Brain (pathology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Organ Size</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Spinal Curvatures (complications)</term><term>Spinal Curvatures (pathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Spinal Curvatures</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Brain</term><term>Parkinson Disease</term><term>Spinal Curvatures</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Organ Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Camptocormia is characterized by an excessive anterior flexion of the spine that appears only when standing or walking. The origin of this symptom remains unknown, but recent clinical reports of camptocormia associated with Parkinson's disease (PD) suggest cerebral involvement in the pathogenesis of camptocormia. This study was undertaken to investigate the hypothesis that camptocormia in PD has a central origin. Seventeen PD patients with camptocormia were prospectively enrolled and were compared to 10 matched PD patients without camptocormia and 12 normal controls. The normalized volumes of the brain, striatal nuclei, and the cross-sectional areas of the midbrain and pons were measured on three-dimensional magnetic resonance imaging. Data were correlated with the severity of the symptoms. The normalized axial surface of the midbrain was statistically smaller in PD patients with camptocormia than in normal controls (P = 0.01). The normalized volumetric data were not statistically different in PD patients with camptocormia. There was a significant negative correlation between the severity of camptocormia and the normalized brain volume (P < 0.009; R = -0.649) and sagittal pons area (P < 0.01; R = -0.642). The results suggest that PD with camptocormia may represent a selective form of PD in which a specific neuronal dysfunction possibly occurs within the brainstem.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002528 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002528 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:18351343
|texte= Camptocormia and Parkinson's disease: MR imaging.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:18351343" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |