Diagnosis and management of Parkinson's disease dementia
Identifieur interne : 002523 ( Main/Merge ); précédent : 002522; suivant : 002524Diagnosis and management of Parkinson's disease dementia
Auteurs : Werner Poewe [Autriche] ; S. Gauthier [Canada] ; D. Aarsland [Norvège] ; J B Leverenz [États-Unis] ; P. Barone [Italie] ; D. Weintraub [États-Unis] ; E. Tolosa [Espagne] ; B. Dubois [France]Source :
- International Journal of Clinical Practice [ 1368-5031 ] ; 2008.
Abstract
Parkinson's disease (PD) has long been considered predominantly a motor disorder. However, its frequent association with dementia, which contributes significantly to the morbidity and mortality of the condition, is gaining increasing recognition. PD dementia (PDD) has a unique clinical profile and neuropathology, distinct from Alzheimer's disease (AD). Cholinergic deficits, a feature of both AD and PDD, underlie the rationale for cholinesterase inhibitor therapy in both conditions. In clinical practice, it is important that PDD should be recognised and appropriately treated. This review aims to outline the recently proposed clinical diagnostic criteria for PDD and to summarise the guidelines/recommendations published since 2006 on the use of cholinesterase inhibitors in the management of PDD. Although the cholinesterase inhibitor rivastigmine has recently been approved for the management of PDD, there remains a need for the development of novel therapies that can affect key mechanisms of the disease or prevent/delay patients with PD and mild cognitive impairment from progressing to PDD.
Url:
DOI: 10.1111/j.1742-1241.2008.01869.x
PubMed: 18822028
PubMed Central: 2658001
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000889
- to stream Pmc, to step Curation: 000886
- to stream Pmc, to step Checkpoint: 000860
- to stream Ncbi, to step Merge: 000909
- to stream Ncbi, to step Curation: 000909
- to stream Ncbi, to step Checkpoint: 000909
Links to Exploration step
PMC:2658001Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnosis and management of Parkinson's disease dementia</title>
<author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Medical University Innsbruck</institution>
<addr-line>Innsbruck, Austria</addr-line>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S" last="Gauthier">S. Gauthier</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, Douglas Mental Health University Institute</institution>
<addr-line>Montréal, QC, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montréal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Norweigen Centre for Movement Disorders, Stavenger University Hospital</institution>
<addr-line>Stavenger, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Stavenger</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Institute of Clinical Medicine, University of Bergen</institution>
<addr-line>Bergen, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leverenz, J B" sort="Leverenz, J B" uniqKey="Leverenz J" first="J B" last="Leverenz">J B Leverenz</name>
<affiliation wicri:level="2"><nlm:aff id="au5"><institution>Mental Illness and Parkinson's Disease Research Education and Clinical Centers, VA-PSHCS, and Departments of Neurology and Psychiatry and Behavioral Sciences, University of Washington</institution>
<addr-line>Seattle, WA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barone, P" sort="Barone, P" uniqKey="Barone P" first="P" last="Barone">P. Barone</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Dipartimento di Scienze Neurologiche, Università Federico II di Napoli</institution>
<addr-line>Naples, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weintraub, D" sort="Weintraub, D" uniqKey="Weintraub D" first="D" last="Weintraub">D. Weintraub</name>
<affiliation wicri:level="2"><nlm:aff id="au7"><institution>Department of Psychiatry, University of Pennsylvania</institution>
<addr-line>Philadelphia, PA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>Parkinson's Disease and Movement Disorders Unit, Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona</institution>
<addr-line>Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>INSERM-UPMC UMRS 610, Federation of Neurology, Salpêtrière Hospital; University of Paris</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18822028</idno>
<idno type="pmc">2658001</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658001</idno>
<idno type="RBID">PMC:2658001</idno>
<idno type="doi">10.1111/j.1742-1241.2008.01869.x</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000889</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000889</idno>
<idno type="wicri:Area/Pmc/Curation">000886</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000886</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000860</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000860</idno>
<idno type="wicri:Area/Ncbi/Merge">000909</idno>
<idno type="wicri:Area/Ncbi/Curation">000909</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000909</idno>
<idno type="wicri:doubleKey">1368-5031:2008:Poewe W:diagnosis:and:management</idno>
<idno type="wicri:Area/Main/Merge">002523</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnosis and management of Parkinson's disease dementia</title>
<author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Neurology, Medical University Innsbruck</institution>
<addr-line>Innsbruck, Austria</addr-line>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Innsbruck</wicri:regionArea>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
<author><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S" last="Gauthier">S. Gauthier</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Alzheimer's Disease Research Unit, McGill Centre for Studies in Aging, Douglas Mental Health University Institute</institution>
<addr-line>Montréal, QC, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montréal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Norweigen Centre for Movement Disorders, Stavenger University Hospital</institution>
<addr-line>Stavenger, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Stavenger</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Institute of Clinical Medicine, University of Bergen</institution>
<addr-line>Bergen, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Bergen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leverenz, J B" sort="Leverenz, J B" uniqKey="Leverenz J" first="J B" last="Leverenz">J B Leverenz</name>
<affiliation wicri:level="2"><nlm:aff id="au5"><institution>Mental Illness and Parkinson's Disease Research Education and Clinical Centers, VA-PSHCS, and Departments of Neurology and Psychiatry and Behavioral Sciences, University of Washington</institution>
<addr-line>Seattle, WA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barone, P" sort="Barone, P" uniqKey="Barone P" first="P" last="Barone">P. Barone</name>
<affiliation wicri:level="1"><nlm:aff id="au6"><institution>Dipartimento di Scienze Neurologiche, Università Federico II di Napoli</institution>
<addr-line>Naples, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Naples</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weintraub, D" sort="Weintraub, D" uniqKey="Weintraub D" first="D" last="Weintraub">D. Weintraub</name>
<affiliation wicri:level="2"><nlm:aff id="au7"><institution>Department of Psychiatry, University of Pennsylvania</institution>
<addr-line>Philadelphia, PA, USA</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<affiliation wicri:level="1"><nlm:aff id="au8"><institution>Parkinson's Disease and Movement Disorders Unit, Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona</institution>
<addr-line>Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dubois, B" sort="Dubois, B" uniqKey="Dubois B" first="B" last="Dubois">B. Dubois</name>
<affiliation wicri:level="1"><nlm:aff id="au9"><institution>INSERM-UPMC UMRS 610, Federation of Neurology, Salpêtrière Hospital; University of Paris</institution>
<addr-line>Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Clinical Practice</title>
<idno type="ISSN">1368-5031</idno>
<idno type="eISSN">1742-1241</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) has long been considered predominantly a motor disorder. However, its frequent association with dementia, which contributes significantly to the morbidity and mortality of the condition, is gaining increasing recognition. PD dementia (PDD) has a unique clinical profile and neuropathology, distinct from Alzheimer's disease (AD). Cholinergic deficits, a feature of both AD and PDD, underlie the rationale for cholinesterase inhibitor therapy in both conditions. In clinical practice, it is important that PDD should be recognised and appropriately treated. This review aims to outline the recently proposed clinical diagnostic criteria for PDD and to summarise the guidelines/recommendations published since 2006 on the use of cholinesterase inhibitors in the management of PDD. Although the cholinesterase inhibitor rivastigmine has recently been approved for the management of PDD, there remains a need for the development of novel therapies that can affect key mechanisms of the disease or prevent/delay patients with PD and mild cognitive impairment from progressing to PDD.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002523 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002523 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:2658001 |texte= Diagnosis and management of Parkinson's disease dementia }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:18822028" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |