No pathogenic rearrangement within the DISC 1 gene in psychosis
Identifieur interne : 002214 ( Main/Merge ); précédent : 002213; suivant : 002215No pathogenic rearrangement within the DISC 1 gene in psychosis
Auteurs : Solenn Legallic [France] ; Jacqueline Bou [France] ; Sadeq Haouzir [France] ; Gabrielle Allio [France] ; Caroline Demily [France] ; Michel Petit [France] ; Thierry Frebourg [France] ; Florence Thibaut [France] ; Dominique Campion [France]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2009-01-05.
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- KwdEn :
Abstract
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR‐based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. © 2008 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.b.30753
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ISTEX:289427CE17EE143EF876A095D0521F3D8E0022C4Le document en format XML
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<front><div type="abstract" xml:lang="en">A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR‐based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. © 2008 Wiley‐Liss, Inc.</div>
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