Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease
Identifieur interne : 001E85 ( Main/Merge ); précédent : 001E84; suivant : 001E86Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease
Auteurs : M. U. Ferraye [France] ; B. Debu [France] ; V. Fraix [France] ; L. Goetz [France] ; C. Ardouin [France] ; J. Yelnik [France] ; C. Henry-Lagrange [France] ; E. Seigneuret [France] ; B. Piallat [France] ; P. Krack [France] ; J.-F. Le Bas [France] ; A.-L. Benabid [France] ; S. Chabardes [France] ; P. Pollak [France]Source :
- Brain [ 0006-8950 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Gait disturbances are frequent and disabling in advanced Parkinson's disease. These symptoms respond poorly to usual medical and surgical treatments but were reported to be improved by stimulation of the pedunculopontine nucleus. We studied the effects of stimulating the pedunculopontine nucleus area in six patients with severe freezing of gait, unresponsive to levodopa and subthalamic nucleus stimulation. Electrodes were implanted bilaterally in the pedunculopontine nucleus area. Electrode placement was checked by postoperative magnetic resonance imaging. The primary outcome measures were a composite gait score, freezing of gait questionnaire score and duration of freezing episodes occurring during a walking protocol at baseline and one-year follow-up. A double-blind cross-over study was carried out from months 4 to 6 after surgery with or without pedunculopontine nucleus area stimulation. At one-year follow-up, the duration of freezing episodes under off-drug condition improved, as well as falls related to freezing. The other primary outcome measures did not significantly change, nor did the results during the double-blind evaluation. Individual results showed major improvement of all gait measures in one patient, moderate improvement of some tests in four patients and global worsening in one patient. Stimulation frequency ranged between 15 and 25 Hz. Oscillopsia and limb myoclonus could hinder voltage increase. No serious adverse events occurred. Although freezing of gait can be improved by low-frequency electrical stimulation of the pedunculopontine nucleus area in some patients with Parkinson's disease our overall results are disappointing compared to the high levels of expectation raised by previous open label studies. Further controlled studies are needed to determine whether optimization of patient selection, targeting and setting of stimulation parameters might improve the outcome to a point that could transform this experimental approach to a treatment with a reasonable risk-benefit ratio.
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Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Chabardes, S" sort="Chabardes, S" uniqKey="Chabardes S" first="S." last="Chabardes">S. Chabardes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0060220</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0060220 INIST</idno><idno type="RBID">Pascal:10-0060220</idno><idno type="wicri:Area/PascalFrancis/Corpus">000620</idno><idno type="wicri:Area/PascalFrancis/Curation">000D37</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000498</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000498</idno><idno type="wicri:doubleKey">0006-8950:2010:Ferraye M:effects:of:pedunculopontine</idno><idno type="wicri:Area/Main/Merge">001E85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease</title><author><name sortKey="Ferraye, M U" sort="Ferraye, M U" uniqKey="Ferraye M" first="M. U." last="Ferraye">M. U. Ferraye</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Debu, B" sort="Debu, B" uniqKey="Debu B" first="B." last="Debu">B. Debu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V." last="Fraix">V. Fraix</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Goetz, L" sort="Goetz, L" uniqKey="Goetz L" first="L." last="Goetz">L. Goetz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Ardouin, C" sort="Ardouin, C" uniqKey="Ardouin C" first="C." last="Ardouin">C. Ardouin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J." last="Yelnik">J. Yelnik</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM UMR_S975, Fédération de Neurologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University Pierre et Marie Curie</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Hôpital de la Pitié-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Henry Lagrange, C" sort="Henry Lagrange, C" uniqKey="Henry Lagrange C" first="C." last="Henry-Lagrange">C. Henry-Lagrange</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E." last="Seigneuret">E. Seigneuret</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B." last="Piallat">B. Piallat</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation></author><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P." last="Krack">P. Krack</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J.-F." last="Le Bas">J.-F. Le Bas</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A.-L." last="Benabid">A.-L. Benabid</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Chabardes, S" sort="Chabardes, S" uniqKey="Chabardes S" first="S." last="Chabardes">S. Chabardes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Grenoble</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University of Grenoble</wicri:noRegion><wicri:noRegion>University of Grenoble</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U836, Grenoble Institute of Neuroscience</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Grenoble Institute of Neuroscience</wicri:noRegion><wicri:noRegion>INSERM, U836, Grenoble Institute of Neuroscience</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital of Grenoble</s1><s3>FRA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gait disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble de la marche</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gait disturbances are frequent and disabling in advanced Parkinson's disease. These symptoms respond poorly to usual medical and surgical treatments but were reported to be improved by stimulation of the pedunculopontine nucleus. We studied the effects of stimulating the pedunculopontine nucleus area in six patients with severe freezing of gait, unresponsive to levodopa and subthalamic nucleus stimulation. Electrodes were implanted bilaterally in the pedunculopontine nucleus area. Electrode placement was checked by postoperative magnetic resonance imaging. The primary outcome measures were a composite gait score, freezing of gait questionnaire score and duration of freezing episodes occurring during a walking protocol at baseline and one-year follow-up. A double-blind cross-over study was carried out from months 4 to 6 after surgery with or without pedunculopontine nucleus area stimulation. At one-year follow-up, the duration of freezing episodes under off-drug condition improved, as well as falls related to freezing. The other primary outcome measures did not significantly change, nor did the results during the double-blind evaluation. Individual results showed major improvement of all gait measures in one patient, moderate improvement of some tests in four patients and global worsening in one patient. Stimulation frequency ranged between 15 and 25 Hz. Oscillopsia and limb myoclonus could hinder voltage increase. No serious adverse events occurred. Although freezing of gait can be improved by low-frequency electrical stimulation of the pedunculopontine nucleus area in some patients with Parkinson's disease our overall results are disappointing compared to the high levels of expectation raised by previous open label studies. Further controlled studies are needed to determine whether optimization of patient selection, targeting and setting of stimulation parameters might improve the outcome to a point that could transform this experimental approach to a treatment with a reasonable risk-benefit ratio.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Ferraye, M U" sort="Ferraye, M U" uniqKey="Ferraye M" first="M. U." last="Ferraye">M. U. Ferraye</name></noRegion><name sortKey="Ardouin, C" sort="Ardouin, C" uniqKey="Ardouin C" first="C." last="Ardouin">C. Ardouin</name><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A.-L." last="Benabid">A.-L. Benabid</name><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A.-L." last="Benabid">A.-L. Benabid</name><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A.-L." last="Benabid">A.-L. Benabid</name><name sortKey="Chabardes, S" sort="Chabardes, S" uniqKey="Chabardes S" first="S." last="Chabardes">S. Chabardes</name><name sortKey="Chabardes, S" sort="Chabardes, S" uniqKey="Chabardes S" first="S." last="Chabardes">S. Chabardes</name><name sortKey="Chabardes, S" sort="Chabardes, S" uniqKey="Chabardes S" first="S." last="Chabardes">S. Chabardes</name><name sortKey="Debu, B" sort="Debu, B" uniqKey="Debu B" first="B." last="Debu">B. Debu</name><name sortKey="Debu, B" sort="Debu, B" uniqKey="Debu B" first="B." last="Debu">B. Debu</name><name sortKey="Ferraye, M U" sort="Ferraye, M U" uniqKey="Ferraye M" first="M. U." last="Ferraye">M. U. Ferraye</name><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V." last="Fraix">V. Fraix</name><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V." last="Fraix">V. Fraix</name><name sortKey="Goetz, L" sort="Goetz, L" uniqKey="Goetz L" first="L." last="Goetz">L. Goetz</name><name sortKey="Goetz, L" sort="Goetz, L" uniqKey="Goetz L" first="L." last="Goetz">L. Goetz</name><name sortKey="Henry Lagrange, C" sort="Henry Lagrange, C" uniqKey="Henry Lagrange C" first="C." last="Henry-Lagrange">C. Henry-Lagrange</name><name sortKey="Henry Lagrange, C" sort="Henry Lagrange, C" uniqKey="Henry Lagrange C" first="C." last="Henry-Lagrange">C. Henry-Lagrange</name><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P." last="Krack">P. Krack</name><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P." last="Krack">P. Krack</name><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P." last="Krack">P. Krack</name><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J.-F." last="Le Bas">J.-F. Le Bas</name><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J.-F." last="Le Bas">J.-F. Le Bas</name><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J.-F." last="Le Bas">J.-F. Le Bas</name><name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B." last="Piallat">B. Piallat</name><name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B." last="Piallat">B. Piallat</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E." last="Seigneuret">E. Seigneuret</name><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J." last="Yelnik">J. Yelnik</name><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J." last="Yelnik">J. Yelnik</name><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J." last="Yelnik">J. Yelnik</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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