ParkinsonFranceV1, Main, Merge, bibRecord, 001950

CONTRIBUTION OF PRE-SYNAPTIC MECHANISMS TO L-DOPA-INDUCED DYSKINESIA

Identifieur interne : 001950 ( Main/Merge ); précédent : 001949; suivant : 001951

CONTRIBUTION OF PRE-SYNAPTIC MECHANISMS TO L-DOPA-INDUCED DYSKINESIA

Auteurs : M. Carta [Suède, Italie] ; E. Bezard [France]

Source :

Neuroscience [ 0306-4522 ] ; 2011.

RBID : Pascal:12-0055978

Descripteurs français

Pascal (Inist)
- Lévodopa, Dopamine, Sérotonine, Maladie de Parkinson.

English descriptors

KwdEn :
- Dopamine, Levodopa, Parkinson disease, Serotonin.

Abstract

Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic L-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of L-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.

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Pascal:12-0055978

Le document en format XML

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<front><div type="abstract" xml:lang="en">Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic L-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key role in the induction of dyskinesia. In this article we review the evidences pointing to the serotonin system as the primary cause for the abnormally high levels of L-DOPA-derived extracellular DA in Parkinson's disease, and we discuss the feasibility of a therapeutic approach targeting this system.</div>
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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
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   |type=    RBID
   |clé=     Pascal:12-0055978
   |texte=   CONTRIBUTION OF PRE-SYNAPTIC MECHANISMS TO L-DOPA-INDUCED DYSKINESIA
}}

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

CONTRIBUTION OF PRE-SYNAPTIC MECHANISMS TO L-DOPA-INDUCED DYSKINESIA

CONTRIBUTION OF PRE-SYNAPTIC MECHANISMS TO L-DOPA-INDUCED DYSKINESIA

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri