Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
Identifieur interne : 001609 ( Main/Merge ); précédent : 001608; suivant : 001610Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
Auteurs : M U Ferraye [France] ; B. Debû ; V. Fraix ; P. Krack ; S. Charbardès ; E. Seigneuret ; A-L Benabid ; P. PollakSource :
- Journal of neural transmission (Vienna, Austria : 1996) [ 1435-1463 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Pedunculopontine Tegmental Nucleus, Subthalamic Nucleus.
- therapy : Gait Disorders, Neurologic, Parkinson Disease.
- Animals, Biophysics, Humans.
Abstract
Stimulation of the subthalamic nucleus (STN) improves the cardinal features of Parkinson disease (PD). However, its efficacy on gait disorders is less satisfying in the long term. In recent years, the pedunculopontine (PPN) nucleus has emerged as a possible promising deep brain stimulation target for gait disorders in PD. In this review, we examine whether STN and PPN act synergistically or antagonistically. Results suggest that the combination of STN and PPN stimulations leads to a significant further improvement in gait as compared with STN stimulation alone, but additive effects on the classical motor triad are questionable. Thus, they highlight the specificity of STN stimulation over PPN's for the PD cardinal features and the specificity of PPN stimulation over STN for gait disorders. In addition, low-frequency stimulation of the PPN may improve alertness. The additive rather than potentiating effects of STN and PPN stimulations suggest that they may be mediated by distinct pathways. Nevertheless, considering the inconsistencies in published results regarding the influence of PPN stimulation on gait disorders, work is still needed before one can know whether it will convert into a standard surgical treatment and to decipher its place beside STN stimulation.
DOI: 10.1007/s00702-011-0673-y
PubMed: 21695419
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000941
- to stream PubMed, to step Curation: 000901
- to stream PubMed, to step Checkpoint: 000901
- to stream Ncbi, to step Merge: 000D43
- to stream Ncbi, to step Curation: 000D43
- to stream Ncbi, to step Checkpoint: 000D43
Links to Exploration step
pubmed:21695419Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?</title><author><name sortKey="Ferraye, M U" sort="Ferraye, M U" uniqKey="Ferraye M" first="M U" last="Ferraye">M U Ferraye</name><affiliation wicri:level="3"><nlm:affiliation>University J. Fourier Grenoble 1, 38041, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University J. Fourier Grenoble 1, 38041, Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Debu, B" sort="Debu, B" uniqKey="Debu B" first="B" last="Debû">B. Debû</name></author><author><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V" last="Fraix">V. Fraix</name></author><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name></author><author><name sortKey="Charbardes, S" sort="Charbardes, S" uniqKey="Charbardes S" first="S" last="Charbardès">S. Charbardès</name></author><author><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E" last="Seigneuret">E. Seigneuret</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A-L" last="Benabid">A-L Benabid</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21695419</idno><idno type="pmid">21695419</idno><idno type="doi">10.1007/s00702-011-0673-y</idno><idno type="wicri:Area/PubMed/Corpus">000941</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000941</idno><idno type="wicri:Area/PubMed/Curation">000901</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000901</idno><idno type="wicri:Area/PubMed/Checkpoint">000901</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000901</idno><idno type="wicri:Area/Ncbi/Merge">000D43</idno><idno type="wicri:Area/Ncbi/Curation">000D43</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D43</idno><idno type="wicri:Area/Main/Merge">001609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?</title><author><name sortKey="Ferraye, M U" sort="Ferraye, M U" uniqKey="Ferraye M" first="M U" last="Ferraye">M U Ferraye</name><affiliation wicri:level="3"><nlm:affiliation>University J. Fourier Grenoble 1, 38041, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University J. Fourier Grenoble 1, 38041, Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Debu, B" sort="Debu, B" uniqKey="Debu B" first="B" last="Debû">B. Debû</name></author><author><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V" last="Fraix">V. Fraix</name></author><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name></author><author><name sortKey="Charbardes, S" sort="Charbardes, S" uniqKey="Charbardes S" first="S" last="Charbardès">S. Charbardès</name></author><author><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E" last="Seigneuret">E. Seigneuret</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A-L" last="Benabid">A-L Benabid</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author></analytic><series><title level="j">Journal of neural transmission (Vienna, Austria : 1996)</title><idno type="eISSN">1435-1463</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biophysics</term><term>Deep Brain Stimulation (methods)</term><term>Gait Disorders, Neurologic (therapy)</term><term>Humans</term><term>Parkinson Disease (therapy)</term><term>Pedunculopontine Tegmental Nucleus (physiology)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biophysics</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stimulation of the subthalamic nucleus (STN) improves the cardinal features of Parkinson disease (PD). However, its efficacy on gait disorders is less satisfying in the long term. In recent years, the pedunculopontine (PPN) nucleus has emerged as a possible promising deep brain stimulation target for gait disorders in PD. In this review, we examine whether STN and PPN act synergistically or antagonistically. Results suggest that the combination of STN and PPN stimulations leads to a significant further improvement in gait as compared with STN stimulation alone, but additive effects on the classical motor triad are questionable. Thus, they highlight the specificity of STN stimulation over PPN's for the PD cardinal features and the specificity of PPN stimulation over STN for gait disorders. In addition, low-frequency stimulation of the PPN may improve alertness. The additive rather than potentiating effects of STN and PPN stimulations suggest that they may be mediated by distinct pathways. Nevertheless, considering the inconsistencies in published results regarding the influence of PPN stimulation on gait disorders, work is still needed before one can know whether it will convert into a standard surgical treatment and to decipher its place beside STN stimulation.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001609 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001609 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:21695419
|texte= Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:21695419" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |