ParkinsonFranceV1, Main, Merge, bibRecord, 001214

Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.

Identifieur interne : 001214 ( Main/Merge ); précédent : 001213; suivant : 001215

Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.

Auteurs : Sophie Drapier [France] ; Anne-Sophie Gillioz ; Emmanuelle Leray ; Julie Péron ; Tiphaine Rouaud ; Annaig Marchand ; Marc Vérin

Source :

Parkinsonism & related disorders [ 1873-5126 ] ; 2012.

RBID : pubmed:21890396

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Apomorphine (administration & dosage), Deep Brain Stimulation (contraindications), Female, Follow-Up Studies, Humans, Infusions, Subcutaneous, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Severity of Illness Index, Subthalamic Nucleus, Treatment Outcome.
MESH :
- chemical , administration & dosage : Antiparkinson Agents, Apomorphine.
- contraindications : Deep Brain Stimulation.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Female, Follow-Up Studies, Humans, Infusions, Subcutaneous, Male, Middle Aged, Severity of Illness Index, Subthalamic Nucleus, Treatment Outcome.

Abstract

The efficacy of continuous subcutaneous apomorphine infusion (APO) has been evaluated in advanced Parkinson's disease in several open-label studies but never in a population of patients for whom subthalamic nucleus deep brain stimulation (STN-DBS) was contraindicated.

Url:

https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133884

DOI: 10.1016/j.parkreldis.2011.08.010
PubMed: 21890396

Links to Exploration step

pubmed:21890396

Le document en format XML

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  <desc>    <address>      <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
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    <ref type="url">http://www.univ-rennes1.fr/</ref>
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<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
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<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
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<author><name sortKey="Marchand, Annaig" sort="Marchand, Annaig" uniqKey="Marchand A" first="Annaig" last="Marchand">Annaig Marchand</name>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-155115" status="VALID">  <orgName>Service de Neurologie [Rennes]</orgName>
  <desc>    <address>      <addrLine>2 Rue Henri Le Guilloux 35033 Rennes Cedex 9</addrLine>
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  <desc>    <address>      <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univ-rennes1.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID">  <orgName>Hôpital Pontchaillou</orgName>
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    </address>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID">  <orgName>CHU Pontchaillou [Rennes]</orgName>
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      <country key="FR"></country>
    </address>
    <ref type="url">http://www.chu-rennes.fr/</ref>
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<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
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<orgName type="university">Université de Rennes 1</orgName>
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<idno type="DOI">10.1016/j.parkreldis.2011.08.010</idno>
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<front><div type="abstract" xml:lang="en">The efficacy of continuous subcutaneous apomorphine infusion (APO) has been evaluated in advanced Parkinson's disease in several open-label studies but never in a population of patients for whom subthalamic nucleus deep brain stimulation (STN-DBS) was contraindicated. The aim of this study was to evaluate the efficacy and cognitive safety of APO at 12-month follow-up in 23 advanced parkinsonian patients (mean age: 62.3 years; mean disease duration: 13.9 years) whose dopa-resistant axial motor symptoms and/or cognitive decline constituted contraindications for STN-DBS. Their motor and cognitive status were evaluated before APO and 12 months afterwards. After one year, patients expressed high levels of satisfaction, with a mean rating on the Visual Analog Scale of 52.8% under APO. Daily OFF time, recorded in a 24-h diary, was reduced by 36% and ON time improved by 48%. There was a significant reduction (-26%) in mean oral levodopa equivalent dose. Dopa-resistant axial symptoms and neuropsychological performance remained stable. No adverse event was noted and none of the patients needed to take clozapine at any time. APO is both safe and effective in advanced parkinsonian patients with untreatable motor fluctuations, for whom STN-DBS is contraindicated due to dopa-resistant axial motor symptoms and/or cognitive decline. As such, it should be regarded as a viable alternative for these patients.</div>
</front>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.</title>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital, Service de Neurologie, CHU Pontchaillou, 2 rue Henri le Guilloux, 35033 Rennes Cedex, France. sophie.drapier@chu-rennes.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, University Hospital, Service de Neurologie, CHU Pontchaillou, 2 rue Henri le Guilloux, 35033 Rennes Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gillioz, Anne Sophie" sort="Gillioz, Anne Sophie" uniqKey="Gillioz A" first="Anne-Sophie" last="Gillioz">Anne-Sophie Gillioz</name>
</author>
<author><name sortKey="Leray, Emmanuelle" sort="Leray, Emmanuelle" uniqKey="Leray E" first="Emmanuelle" last="Leray">Emmanuelle Leray</name>
</author>
<author><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name>
</author>
<author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name>
</author>
<author><name sortKey="Marchand, Annaig" sort="Marchand, Annaig" uniqKey="Marchand A" first="Annaig" last="Marchand">Annaig Marchand</name>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:21890396</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.</title>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital, Service de Neurologie, CHU Pontchaillou, 2 rue Henri le Guilloux, 35033 Rennes Cedex, France. sophie.drapier@chu-rennes.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, University Hospital, Service de Neurologie, CHU Pontchaillou, 2 rue Henri le Guilloux, 35033 Rennes Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
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</author>
<author><name sortKey="Gillioz, Anne Sophie" sort="Gillioz, Anne Sophie" uniqKey="Gillioz A" first="Anne-Sophie" last="Gillioz">Anne-Sophie Gillioz</name>
</author>
<author><name sortKey="Leray, Emmanuelle" sort="Leray, Emmanuelle" uniqKey="Leray E" first="Emmanuelle" last="Leray">Emmanuelle Leray</name>
</author>
<author><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name>
</author>
<author><name sortKey="Rouaud, Tiphaine" sort="Rouaud, Tiphaine" uniqKey="Rouaud T" first="Tiphaine" last="Rouaud">Tiphaine Rouaud</name>
</author>
<author><name sortKey="Marchand, Annaig" sort="Marchand, Annaig" uniqKey="Marchand A" first="Annaig" last="Marchand">Annaig Marchand</name>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name>
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<series><title level="j">Parkinsonism & related disorders</title>
<idno type="eISSN">1873-5126</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (administration & dosage)</term>
<term>Apomorphine (administration & dosage)</term>
<term>Deep Brain Stimulation (contraindications)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Infusions, Subcutaneous</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="contraindications" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Infusions, Subcutaneous</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">The efficacy of continuous subcutaneous apomorphine infusion (APO) has been evaluated in advanced Parkinson's disease in several open-label studies but never in a population of patients for whom subthalamic nucleus deep brain stimulation (STN-DBS) was contraindicated.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.

Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.