ParkinsonFranceV1, Main, Merge, bibRecord, 000E02

Anatomo-clinical atlases correlate clinical data and electrode contact coordinates: application to subthalamic deep brain stimulation.

Identifieur interne : 000E02 ( Main/Merge ); précédent : 000E01; suivant : 000E03

Anatomo-clinical atlases correlate clinical data and electrode contact coordinates: application to subthalamic deep brain stimulation.

Auteurs : Florent Lalys [France] ; Claire Haegelen ; Maroua Mehri ; Sophie Drapier ; Marc Vérin ; Pierre Jannin

Source :

Journal of neuroscience methods [ 1872-678X ] ; 2013.

RBID : pubmed:23147008

English descriptors

KwdEn :
- Anatomy, Regional, Atlases as Topic, Deep Brain Stimulation (methods), Electrodes, Implanted, Female, Humans, Male, Middle Aged, Parkinson Disease (therapy), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (physiopathology).
MESH :
- anatomy & histology : Subthalamic Nucleus.
- methods : Deep Brain Stimulation.
- physiopathology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Anatomy, Regional, Atlases as Topic, Electrodes, Implanted, Female, Humans, Male, Middle Aged.
mix :
- Deep brain stimulation, Parkinson disease, anatomo-clinical atlas, medical imaging.

Abstract

For patients suffering from Parkinson's disease with severe movement disorders, functional surgery may be required when medical therapy is not effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). The quality of patient surgical outcome is generally related to the accuracy of nucleus targeting during surgery. In this paper, we focused on identifying optimum sites for STN DBS by studying symptomatic motor improvement along with neuropsychological side effects. We described successive steps for constructing digital atlases gathering patient's location of electrode contacts automatically segmented from postoperative images, and clinical scores. Three motor and five neuropsychological scores were included in the study. Correlations with active contact locations were carried out using an adapted hierarchical ascendant classification. Such analysis enabled the extraction of representative clusters to determine the optimum site for therapeutic STN DBS. For each clinical score, we built an anatomo-clinical atlas representing its improvement or deterioration in relation with the anatomical location of electrodes and from a population of implanted patients. To the best of our knowledge, we reported for the first time a discrepancy between a very good motor improvement by targeting the postero-superior region of the STN and an inevitable deterioration of the categorical and phonemic fluency in the same region. Such atlases and associated analysis may help better understanding of functional mapping in deep structures and may help pre-operative decision-making process and especially targeting.

Url:

http://www.hal.inserm.fr/inserm-00750921

DOI: 10.1016/j.jneumeth.2012.11.002
PubMed: 23147008

Links to Exploration step

pubmed:23147008

Le document en format XML

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La maladie de Parkinson en France (serveur d'exploration)

Anatomo-clinical atlases correlate clinical data and electrode contact coordinates: application to subthalamic deep brain stimulation.

Anatomo-clinical atlases correlate clinical data and electrode contact coordinates: application to subthalamic deep brain stimulation.

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	La maladie de Parkinson en France (serveur d'exploration)
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