Modeling depression in Parkinson disease
Identifieur interne : 000D10 ( Main/Merge ); précédent : 000D09; suivant : 000D11Modeling depression in Parkinson disease
Auteurs : Albert F. G. Leentjens ; Anja J. H. Moonen ; Kathy DujardinSource :
- Neurology [ 0028-3878 ] ; 2013.
English descriptors
- KwdEn :
- Activities of Daily Living (psychology), Aged, Cross-Sectional Studies, Depression (etiology), Depression (psychology), Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Risk Factors, Severity of Illness Index.
- MESH :
- complications : Parkinson Disease.
- etiology : Depression.
- psychology : Activities of Daily Living, Depression, Parkinson Disease.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Risk Factors, Severity of Illness Index.
Abstract
To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.
Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD.
A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors.
In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.
Url:
DOI: 10.1212/WNL.0b013e3182a4a503
PubMed: 23946309
PubMed Central: 3795592
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000526
- to stream Pmc, to step Curation: 000523
- to stream Pmc, to step Checkpoint: 000480
- to stream PubMed, to step Corpus: 000686
- to stream PubMed, to step Curation: 000658
- to stream PubMed, to step Checkpoint: 000658
- to stream Ncbi, to step Merge: 001194
- to stream Ncbi, to step Curation: 001194
- to stream Ncbi, to step Checkpoint: 001194
Links to Exploration step
PMC:3795592Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modeling depression in Parkinson disease</title>
<author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name>
</author>
<author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23946309</idno>
<idno type="pmc">3795592</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795592</idno>
<idno type="RBID">PMC:3795592</idno>
<idno type="doi">10.1212/WNL.0b013e3182a4a503</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000526</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000526</idno>
<idno type="wicri:Area/Pmc/Curation">000523</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000523</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000480</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000480</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000686</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000686</idno>
<idno type="wicri:Area/PubMed/Curation">000658</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000658</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000658</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000658</idno>
<idno type="wicri:Area/Ncbi/Merge">001194</idno>
<idno type="wicri:Area/Ncbi/Curation">001194</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001194</idno>
<idno type="wicri:doubleKey">0028-3878:2013:Leentjens A:modeling:depression:in</idno>
<idno type="wicri:Area/Main/Merge">000D10</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modeling depression in Parkinson disease</title>
<author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name>
</author>
<author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name>
</author>
<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term>
<term>Aged</term>
<term>Cross-Sectional Studies</term>
<term>Depression (etiology)</term>
<term>Depression (psychology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Neurological</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term>
<term>Depression</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Neurological</term>
<term>Neuropsychological Tests</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.</p>
</sec>
<sec><title>Methods:</title>
<p>Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD.</p>
</sec>
<sec><title>Results:</title>
<p>A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors.</p>
</sec>
<sec><title>Conclusion:</title>
<p>In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000D10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:3795592 |texte= Modeling depression in Parkinson disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:23946309" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |