ParkinsonFranceV1, Main, Merge, bibRecord, 000D10

Modeling depression in Parkinson disease

Identifieur interne : 000D10 ( Main/Merge ); précédent : 000D09; suivant : 000D11

Modeling depression in Parkinson disease

Auteurs : Albert F. G. Leentjens ; Anja J. H. Moonen ; Kathy Dujardin

Source :

Neurology [ 0028-3878 ] ; 2013.

RBID : PMC:3795592

English descriptors

KwdEn :
- Activities of Daily Living (psychology), Aged, Cross-Sectional Studies, Depression (etiology), Depression (psychology), Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Risk Factors, Severity of Illness Index.
MESH :
- complications : Parkinson Disease.
- etiology : Depression.
- psychology : Activities of Daily Living, Depression, Parkinson Disease.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Models, Neurological, Neuropsychological Tests, Risk Factors, Severity of Illness Index.

Abstract

Objective:

To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.

Methods:

Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD.

Results:

A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors.

Conclusion:

In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795592

DOI: 10.1212/WNL.0b013e3182a4a503
PubMed: 23946309
PubMed Central: 3795592

Links to Exploration step

PMC:3795592

Le document en format XML

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<author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name>
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<author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name>
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<author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name>
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<series><title level="j">Neurology</title>
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<term>Cross-Sectional Studies</term>
<term>Depression (etiology)</term>
<term>Depression (psychology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Neurological</term>
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<term>Cross-Sectional Studies</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model.</p>
</sec>
<sec><title>Methods:</title>
<p>Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD.</p>
</sec>
<sec><title>Results:</title>
<p>A model with acceptable fit was generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-times-higher influence in the model than PD-specific risk factors.</p>
</sec>
<sec><title>Conclusion:</title>
<p>In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.</p>
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La maladie de Parkinson en France (serveur d'exploration)

Modeling depression in Parkinson disease

Modeling depression in Parkinson disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.