[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Identifieur interne : 000C06 ( Main/Merge ); précédent : 000C05; suivant : 000C07[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Auteurs : Steeve H. Thany [France] ; Pascal Reynier ; Guy LenaersSource :
- Medecine sciences : M/S [ 0767-0974 ] ; 2013.
English descriptors
- KwdEn :
- Alzheimer Disease (chemically induced), Animals, Genetic Predisposition to Disease, Humans, Insecticides (toxicity), Mitochondria (drug effects), Neurodegenerative Diseases (chemically induced), Paraquat (toxicity), Parkinson Disease (genetics), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (genetics), Pesticides (toxicity), Rotenone (toxicity), alpha-Synuclein (metabolism).
- MESH :
- chemical , metabolism : alpha-Synuclein.
- chemical , toxicity : Insecticides, Paraquat, Pesticides, Rotenone.
- chemically induced : Alzheimer Disease, Neurodegenerative Diseases, Parkinson Disease, Secondary.
- drug effects : Mitochondria.
- genetics : Parkinson Disease, Parkinson Disease, Secondary.
- Animals, Genetic Predisposition to Disease, Humans.
Abstract
Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.
DOI: 10.1051/medsci/2013293013
PubMed: 23544381
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pubmed:23544381Le document en format XML
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<term>Insecticides (toxicity)</term>
<term>Mitochondria (drug effects)</term>
<term>Neurodegenerative Diseases (chemically induced)</term>
<term>Paraquat (toxicity)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (genetics)</term>
<term>Pesticides (toxicity)</term>
<term>Rotenone (toxicity)</term>
<term>alpha-Synuclein (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Synuclein</term>
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<term>Paraquat</term>
<term>Pesticides</term>
<term>Rotenone</term>
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<front><div type="abstract" xml:lang="en">Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.</div>
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