[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Identifieur interne : 000C06 ( Main/Merge ); précédent : 000C05; suivant : 000C07[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Auteurs : Steeve H. Thany [France] ; Pascal Reynier ; Guy LenaersSource :
- Medecine sciences : M/S [ 0767-0974 ] ; 2013.
English descriptors
- KwdEn :
- Alzheimer Disease (chemically induced), Animals, Genetic Predisposition to Disease, Humans, Insecticides (toxicity), Mitochondria (drug effects), Neurodegenerative Diseases (chemically induced), Paraquat (toxicity), Parkinson Disease (genetics), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (genetics), Pesticides (toxicity), Rotenone (toxicity), alpha-Synuclein (metabolism).
- MESH :
- chemical , metabolism : alpha-Synuclein.
- chemical , toxicity : Insecticides, Paraquat, Pesticides, Rotenone.
- chemically induced : Alzheimer Disease, Neurodegenerative Diseases, Parkinson Disease, Secondary.
- drug effects : Mitochondria.
- genetics : Parkinson Disease, Parkinson Disease, Secondary.
- Animals, Genetic Predisposition to Disease, Humans.
Abstract
Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.
DOI: 10.1051/medsci/2013293013
PubMed: 23544381
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pubmed:23544381Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].</title><author><name sortKey="Thany, Steeve H" sort="Thany, Steeve H" uniqKey="Thany S" first="Steeve H" last="Thany">Steeve H. Thany</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers, France. steeve.thany@univ-angers.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name></author><author><name sortKey="Lenaers, Guy" sort="Lenaers, Guy" uniqKey="Lenaers G" first="Guy" last="Lenaers">Guy Lenaers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23544381</idno><idno type="pmid">23544381</idno><idno type="doi">10.1051/medsci/2013293013</idno><idno type="wicri:Area/PubMed/Corpus">000762</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000762</idno><idno type="wicri:Area/PubMed/Curation">000729</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000729</idno><idno type="wicri:Area/PubMed/Checkpoint">000729</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000729</idno><idno type="wicri:Area/Ncbi/Merge">001114</idno><idno type="wicri:Area/Ncbi/Curation">001114</idno><idno type="wicri:Area/Ncbi/Checkpoint">001114</idno><idno type="wicri:doubleKey">0767-0974:2013:Thany S:neurotoxicity:of:pesticides</idno><idno type="wicri:Area/Main/Merge">000C06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].</title><author><name sortKey="Thany, Steeve H" sort="Thany, Steeve H" uniqKey="Thany S" first="Steeve H" last="Thany">Steeve H. Thany</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers, France. steeve.thany@univ-angers.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name></author><author><name sortKey="Lenaers, Guy" sort="Lenaers, Guy" uniqKey="Lenaers G" first="Guy" last="Lenaers">Guy Lenaers</name></author></analytic><series><title level="j">Medecine sciences : M/S</title><idno type="ISSN">0767-0974</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (chemically induced)</term><term>Animals</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Insecticides (toxicity)</term><term>Mitochondria (drug effects)</term><term>Neurodegenerative Diseases (chemically induced)</term><term>Paraquat (toxicity)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (genetics)</term><term>Pesticides (toxicity)</term><term>Rotenone (toxicity)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Insecticides</term><term>Paraquat</term><term>Pesticides</term><term>Rotenone</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Alzheimer Disease</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Predisposition to Disease</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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