ParkinsonFranceV1, Main, Merge, bibRecord, 000246

Loss of REM sleep features across nighttime in REM sleep behavior disorder.

Identifieur interne : 000246 ( Main/Merge ); précédent : 000245; suivant : 000247

Loss of REM sleep features across nighttime in REM sleep behavior disorder.

Auteurs : Dario Arnaldi [Italie] ; Alice Latimier [France] ; Smaranda Leu-Semenescu [France] ; Marie Vidailhet [France] ; Isabelle Arnulf [France]

Source :

Sleep medicine [ 1878-5506 ] ; 2016.

RBID : pubmed:26847988

English descriptors

KwdEn :
- Adult, Aged, Chronobiology Disorders (physiopathology), Electromyography, Female, Humans, Male, Melatonin (pharmacology), Melatonin (therapeutic use), Middle Aged, Parkinson Disease (physiopathology), Polysomnography (methods), REM Sleep Behavior Disorder (drug therapy), REM Sleep Behavior Disorder (physiopathology), Sleep Stages.
MESH :
- chemical , pharmacology : Melatonin.
- drug therapy : REM Sleep Behavior Disorder.
- methods : Polysomnography.
- physiopathology : Chronobiology Disorders, Parkinson Disease, REM Sleep Behavior Disorder.
- chemical , therapeutic use : Melatonin.
- Adult, Aged, Electromyography, Female, Humans, Male, Middle Aged, Sleep Stages.
mix :
- Circadian, Melatonin, PD, RBD.

Abstract

Melatonin is a chronobiotic treatment which also alleviates rapid eye movement (REM) sleep behavior disorder (RBD). Because the mechanisms of this benefit are unclear, we evaluated the clock-dependent REM sleep characteristics in patients with RBD, whether idiopathic (iRBD) or associated with Parkinson's Disease (PD), and we compared findings with PD patients without RBD and with healthy subjects.

Url:

http://hal.upmc.fr/hal-01292432

DOI: 10.1016/j.sleep.2015.10.019
PubMed: 26847988

Links to Exploration step

pubmed:26847988

Le document en format XML

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<author><name sortKey="Leu Semenescu, Smaranda" sort="Leu Semenescu, Smaranda" uniqKey="Leu Semenescu S" first="Smaranda" last="Leu-Semenescu">Smaranda Leu-Semenescu</name>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<idno type="DOI">10.1016/j.sleep.2015.10.019</idno>
<series><title level="j">Sleep Medicine</title>
<idno type="ISSN">1389-9457</idno>
<imprint><date type="datePub">2016-01</date>
</imprint>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Circadian</term>
<term>Melatonin</term>
<term>PD</term>
<term>RBD</term>
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<front><div type="abstract" xml:lang="en">ObjectivesMelatonin is a chronobiotic treatment which also alleviates rapid eye movement (REM) sleep behavior disorder (RBD). Because the mechanisms of this benefit are unclear, we evaluated the clock-dependent REM sleep characteristics in patients with RBD, whether idiopathic (iRBD) or associated with Parkinson's Disease (PD), and we compared findings with PD patients without RBD and with healthy subjects.MethodsAn overnight videopolysomnography was performed in ten iRBD patients, ten PD patients with RBD (PD + RBD+), ten PD patients without RBD (PD + RBD−), and ten controls. The rapid eye movement frequency per minute (REMs index), the tonic and phasic electromyographic (EMG) activity of the levator menti muscle, and the duration of each REM sleep episode were evaluated. A generalized linear model was applied in each group, with the REM sleep cycle (four ordinal levels) as the dependent variable, as a function of REMs index, REM sleep duration, and tonic and phasic EMG activity.ResultsFrom the first to the fourth sleep cycle, REM sleep duration progressively increased in controls only, REMs index increased in subjects without RBD but not in patients with RBD, whether idiopathic or associated with PD, whereas tonic and phasic EMG activity did not change.ConclusionsPatients with PD or iRBD lost the physiologic nocturnal increase in REM sleep duration, and patients with RBD (either with or without PD) lost the increase of REMs frequency across the night, suggesting an alteration in the circadian system in RBD. This supports the hypothesis of a direct effect of melatonin on RBD symptoms by its chronobiotic activity.</div>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Sleep Disorders Unit, APHP-Pitié-Salpêtrière Hospital, Paris, France; Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Genova</wicri:regionArea>
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<placeName><region type="region">Île-de-France</region>
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<settlement type="city">Paris</settlement>
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<author><name sortKey="Leu Semenescu, Smaranda" sort="Leu Semenescu, Smaranda" uniqKey="Leu Semenescu S" first="Smaranda" last="Leu-Semenescu">Smaranda Leu-Semenescu</name>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation wicri:level="3"><nlm:affiliation>Sleep Disorders Unit, APHP-Pitié-Salpêtrière Hospital, Paris, France; Brain Research Institute-UPMC Paris 6 Univ, Inserm U 1127, CNRS UMR 7225, Paris, France. Electronic address: isabelle.arnulf@psl.aphp.fr.</nlm:affiliation>
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<wicri:regionArea>Sleep Disorders Unit, APHP-Pitié-Salpêtrière Hospital, Paris, France; Brain Research Institute-UPMC Paris 6 Univ, Inserm U 1127, CNRS UMR 7225, Paris</wicri:regionArea>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<country xml:lang="fr">France</country>
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<series><title level="j">Sleep medicine</title>
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<imprint><date when="2016" type="published">2016</date>
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<front><div type="abstract" xml:lang="en">Melatonin is a chronobiotic treatment which also alleviates rapid eye movement (REM) sleep behavior disorder (RBD). Because the mechanisms of this benefit are unclear, we evaluated the clock-dependent REM sleep characteristics in patients with RBD, whether idiopathic (iRBD) or associated with Parkinson's Disease (PD), and we compared findings with PD patients without RBD and with healthy subjects.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Loss of REM sleep features across nighttime in REM sleep behavior disorder.

Loss of REM sleep features across nighttime in REM sleep behavior disorder.

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	La maladie de Parkinson en France (serveur d'exploration)
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