Measuring prefrontal cortical activity during dual task walking in patients with Parkinson’s disease: feasibility of using a new portable fNIRS device
Identifieur interne : 000240 ( Main/Merge ); précédent : 000239; suivant : 000241Measuring prefrontal cortical activity during dual task walking in patients with Parkinson’s disease: feasibility of using a new portable fNIRS device
Auteurs : Freek Nieuwhof [Pays-Bas] ; Miriam F. Reelick [Pays-Bas] ; Inbal Maidan [Israël] ; Anat Mirelman [Israël] ; Jeffrey M. Hausdorff [Israël] ; Marcel G. M. Olde Rikkert [Pays-Bas] ; Bastiaan R. Bloem [Pays-Bas] ; Makii Muthalib [France] ; Jurgen A. H. R. Claassen [Pays-Bas]Source :
- Pilot and Feasibility Studies [ 2055-5784 ] ; 2016.
Abstract
Many patients with Parkinson’s disease (PD) have difficulties in performing a second task during walking (i.e., dual task walking). Functional near-infrared spectroscopy (fNIRS) is a promising approach to study the presumed contribution of dysfunction within the prefrontal cortex (PFC) to such difficulties. In this pilot study, we examined the feasibility of using a new portable and wireless fNIRS device to measure PFC activity during different dual task walking protocols in PD. Specifically, we tested whether PD patients were able to perform the protocol and whether we were able to measure the typical fNIRS signal of neuronal activity.
We included 14 PD patients (age 71.2 ± 5.4 years, Hoehn and Yahr stage II/III). The protocol consisted of five repetitions of three conditions: walking while (i) counting forwards, (ii) serially subtracting, and (iii) reciting digit spans. Ability to complete this protocol, perceived exertion, burden of the fNIRS devices, and concentrations of oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin from the left and right PFC were measured.
Two participants were unable to complete the protocol due to fatigue and mobility safety concerns. The remaining 12 participants experienced no burden from the two fNIRS devices and completed the protocol with ease. Bilateral PFC O2Hb concentrations increased during walking while serially subtracting (left PFC 0.46 μmol/L, 95 % confidence interval (CI) 0.12–0.81, right PFC 0.49 μmol/L, 95 % CI 0.14–0.84) and reciting digit spans (left PFC 0.36 μmol/L, 95 % CI 0.03–0.70, right PFC 0.44 μmol/L, 95 % CI 0.09–0.78) when compared to rest. HHb concentrations did not differ between the walking tasks and rest.
These findings suggest that a new wireless fNIRS device is a feasible measure of PFC activity in PD during dual task walking. Future studies should reduce the level of noise and inter-individual variability to enable measuring differences in PFC activity between different dual walking conditions and across health states.
The online version of this article (doi:10.1186/s40814-016-0099-2) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40814-016-0099-2
PubMed: 27965875
PubMed Central: 5154104
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Reelick</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Donders Institute for Brain, Cognition and Behaviour, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Maidan, Inbal" sort="Maidan, Inbal" uniqKey="Maidan I" first="Inbal" last="Maidan">Inbal Maidan</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Mirelman, Anat" sort="Mirelman, Anat" uniqKey="Mirelman A" first="Anat" last="Mirelman">Anat Mirelman</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Center for the study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Olde Rikkert, Marcel G M" sort="Olde Rikkert, Marcel G M" uniqKey="Olde Rikkert M" first="Marcel G. M." last="Olde Rikkert">Marcel G. M. Olde Rikkert</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Donders Institute for Brain, Cognition and Behaviour, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Donders Institute for Brain, Cognition and Behaviour, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Muthalib, Makii" sort="Muthalib, Makii" uniqKey="Muthalib M" first="Makii" last="Muthalib">Makii Muthalib</name><affiliation wicri:level="3"><nlm:aff id="Aff5">EuroMov, University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EuroMov, University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Claassen, Jurgen A H R" sort="Claassen, Jurgen A H R" uniqKey="Claassen J" first="Jurgen A. H. R." last="Claassen">Jurgen A. H. R. Claassen</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Donders Institute for Brain, Cognition and Behaviour, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology, Geriatric Medicine, and Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><series><title level="j">Pilot and Feasibility Studies</title><idno type="eISSN">2055-5784</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Many patients with Parkinson’s disease (PD) have difficulties in performing a second task during walking (i.e., dual task walking). Functional near-infrared spectroscopy (fNIRS) is a promising approach to study the presumed contribution of dysfunction within the prefrontal cortex (PFC) to such difficulties. In this pilot study, we examined the feasibility of using a new portable and wireless fNIRS device to measure PFC activity during different dual task walking protocols in PD. Specifically, we tested whether PD patients were able to perform the protocol and whether we were able to measure the typical fNIRS signal of neuronal activity.</p></sec><sec><title>Methods</title><p>We included 14 PD patients (age 71.2 ± 5.4 years, Hoehn and Yahr stage II/III). The protocol consisted of five repetitions of three conditions: walking while (i) counting forwards, (ii) serially subtracting, and (iii) reciting digit spans. Ability to complete this protocol, perceived exertion, burden of the fNIRS devices, and concentrations of oxygenated (O<sub>2</sub>Hb) and deoxygenated (HHb) hemoglobin from the left and right PFC were measured.</p></sec><sec><title>Results</title><p>Two participants were unable to complete the protocol due to fatigue and mobility safety concerns. The remaining 12 participants experienced no burden from the two fNIRS devices and completed the protocol with ease. Bilateral PFC O<sub>2</sub>Hb concentrations increased during walking while serially subtracting (left PFC 0.46 μmol/L, 95 % confidence interval (CI) 0.12–0.81, right PFC 0.49 μmol/L, 95 % CI 0.14–0.84) and reciting digit spans (left PFC 0.36 μmol/L, 95 % CI 0.03–0.70, right PFC 0.44 μmol/L, 95 % CI 0.09–0.78) when compared to rest. HHb concentrations did not differ between the walking tasks and rest.</p></sec><sec><title>Conclusions</title><p>These findings suggest that a new wireless fNIRS device is a feasible measure of PFC activity in PD during dual task walking. Future studies should reduce the level of noise and inter-individual variability to enable measuring differences in PFC activity between different dual walking conditions and across health states.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s40814-016-0099-2) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kelly, Ve" uniqKey="Kelly V">VE Kelly</name></author><author><name sortKey="Eusterbrock, Aj" uniqKey="Eusterbrock A">AJ Eusterbrock</name></author><author><name sortKey="Shumway Cook, A" uniqKey="Shumway Cook A">A Shumway-Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stegemoller, El" uniqKey="Stegemoller E">EL Stegemoller</name></author><author><name sortKey="Wilson, Jp" uniqKey="Wilson J">JP Wilson</name></author><author><name 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Niessing</name></author><author><name sortKey="Wabnitz, H" uniqKey="Wabnitz H">H Wabnitz</name></author><author><name sortKey="Bruhl, R" uniqKey="Bruhl R">R Bruhl</name></author><author><name sortKey="Ittermann, B" uniqKey="Ittermann B">B Ittermann</name></author><author><name sortKey="Jacobs, Am" uniqKey="Jacobs A">AM Jacobs</name></author><author><name sortKey="Tachtsidis, I" uniqKey="Tachtsidis I">I Tachtsidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author><author><name sortKey="Takikawa, Y" uniqKey="Takikawa Y">Y Takikawa</name></author><author><name sortKey="Kawagoe, R" uniqKey="Kawagoe R">R Kawagoe</name></author><author><name sortKey="Shibuya, S" uniqKey="Shibuya S">S Shibuya</name></author><author><name sortKey="Iwano, T" uniqKey="Iwano T">T Iwano</name></author><author><name sortKey="Kitazawa, S" uniqKey="Kitazawa S">S Kitazawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, H" uniqKey="Sato H">H Sato</name></author><author><name sortKey="Yahata, N" uniqKey="Yahata N">N Yahata</name></author><author><name sortKey="Funane, T" uniqKey="Funane T">T Funane</name></author><author><name sortKey="Takizawa, R" uniqKey="Takizawa R">R Takizawa</name></author><author><name sortKey="Katura, T" uniqKey="Katura T">T Katura</name></author><author><name sortKey="Atsumori, H" uniqKey="Atsumori H">H Atsumori</name></author><author><name sortKey="Nishimura, Y" uniqKey="Nishimura Y">Y Nishimura</name></author><author><name sortKey="Kinoshita, A" uniqKey="Kinoshita A">A Kinoshita</name></author><author><name sortKey="Kiguchi, M" uniqKey="Kiguchi M">M Kiguchi</name></author><author><name sortKey="Koizumi, H" uniqKey="Koizumi H">H Koizumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, X" uniqKey="Cui X">X Cui</name></author><author><name sortKey="Bray, S" uniqKey="Bray S">S Bray</name></author><author><name sortKey="Bryant, Dm" uniqKey="Bryant D">DM Bryant</name></author><author><name sortKey="Glover, Gh" uniqKey="Glover G">GH Glover</name></author><author><name sortKey="Reiss, Al" uniqKey="Reiss A">AL Reiss</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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