ParkinsonFranceV1, Main, Merge, bibRecord, 000217

Nigrostriatal dopaminergic depletion increases static orofacial allodynia

Identifieur interne : 000217 ( Main/Merge ); précédent : 000216; suivant : 000218

Nigrostriatal dopaminergic depletion increases static orofacial allodynia

Auteurs : Wisam Dieb [France] ; Omar Ouachikh [France] ; Sofia Alves [France] ; Yves Boucher [France] ; Franck Durif [France] ; Aziz Hafidi [France]

Source :

The Journal of Headache and Pain [ 1129-2369 ] ; 2016.

RBID : PMC:4757596

English descriptors

KwdEn :
- Animals, Behavior, Animal, Constriction, Pathologic (complications), Disease Models, Animal, Dopamine (metabolism), Facial Pain (etiology), Facial Pain (metabolism), Hyperalgesia (etiology), Hyperalgesia (metabolism), Male, Neuralgia (etiology), Neuralgia (metabolism), Rats, Rats, Sprague-Dawley, Substantia Nigra (metabolism).
MESH :
- chemical , metabolism : Dopamine.
- complications : Constriction, Pathologic.
- etiology : Facial Pain, Hyperalgesia, Neuralgia.
- metabolism : Facial Pain, Hyperalgesia, Neuralgia, Substantia Nigra.
- Animals, Behavior, Animal, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley.

Abstract

Background

This study investigated mesencephalic dopamine depletion effects on static mechanical allodynia (SMA) elicited by chronic constriction of the infraorbitary nerve (CCI-IoN).

Methods

Dopamine depletion (6-OHDA administration into the medial forebrain bundle) effects on CCI-IoN-induced SMA were explored using behavioral (nocifensive behavior score upon non-noxious stimuli using von Frey filament), pharmacological (bromocriptine injections) and immunohistochemical (PKCγ and pERK1/2) techniques.

Results

The central dopamine depletion increased significantly the SMA score. Intraperitoneal and intracisternal injections of bromocriptine alleviated the allodynic behavior observed in both CCI-IoN and CCI-IoN + 6-OHDA animal groups. At the cellular level, dopamine depletion induced a significant increase in PKCγ expression in the medullary dorsal horn (MDH) in rat with CCI-IoN + 6-OHDA when compared to sham animals (CCI-IoN only). Similarly, after static non-noxious stimuli, the expression of pain marker proteins pERK1/2 within the MDH revealed significantly a higher number of positive cells in CCI-IoN + 6-OHDA rats when compared to the CCI-IoN group.

Conclusion

This study demonstrates that nigrostriatal dopamine depletion exacerbates the neuropathic pain resulting from CCI-IoN. This effect is probably due to an action through descending pain inhibitory systems which increased pain sensitization at the MDH level. It demonstrates also an analgesic effect elicited by D2R activation at the segmental level.

Electronic supplementary material

The online version of this article (doi:10.1186/s10194-016-0607-z) contains supplementary material, which is available to authorized users.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757596

DOI: 10.1186/s10194-016-0607-z
PubMed: 26885825
PubMed Central: 4757596

Links to Exploration step

PMC:4757596

Le document en format XML

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<term>Behavior, Animal</term>
<term>Constriction, Pathologic (complications)</term>
<term>Disease Models, Animal</term>
<term>Dopamine (metabolism)</term>
<term>Facial Pain (etiology)</term>
<term>Facial Pain (metabolism)</term>
<term>Hyperalgesia (etiology)</term>
<term>Hyperalgesia (metabolism)</term>
<term>Male</term>
<term>Neuralgia (etiology)</term>
<term>Neuralgia (metabolism)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Substantia Nigra (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Constriction, Pathologic</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Facial Pain</term>
<term>Hyperalgesia</term>
<term>Neuralgia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Facial Pain</term>
<term>Hyperalgesia</term>
<term>Neuralgia</term>
<term>Substantia Nigra</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>This study investigated mesencephalic dopamine depletion effects on static mechanical allodynia (SMA) elicited by chronic constriction of the infraorbitary nerve (CCI-IoN).</p>
</sec>
<sec><title>Methods</title>
<p>Dopamine depletion (6-OHDA administration into the medial forebrain bundle) effects on CCI-IoN-induced SMA were explored using behavioral (nocifensive behavior score upon non-noxious stimuli using von Frey filament), pharmacological (bromocriptine injections) and immunohistochemical (PKCγ and pERK1/2) techniques.</p>
</sec>
<sec><title>Results</title>
<p>The central dopamine depletion increased significantly the SMA score. Intraperitoneal and intracisternal injections of bromocriptine alleviated the allodynic behavior observed in both CCI-IoN and CCI-IoN + 6-OHDA animal groups. At the cellular level, dopamine depletion induced a significant increase in PKCγ expression in the medullary dorsal horn (MDH) in rat with CCI-IoN + 6-OHDA when compared to sham animals (CCI-IoN only). Similarly, after static non-noxious stimuli, the expression of pain marker proteins pERK1/2 within the MDH revealed significantly a higher number of positive cells in CCI-IoN + 6-OHDA rats when compared to the CCI-IoN group.</p>
</sec>
<sec><title>Conclusion</title>
<p>This study demonstrates that nigrostriatal dopamine depletion exacerbates the neuropathic pain resulting from CCI-IoN. This effect is probably due to an action through descending pain inhibitory systems which increased pain sensitization at the MDH level. It demonstrates also an analgesic effect elicited by D2R activation at the segmental level.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s10194-016-0607-z) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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La maladie de Parkinson en France (serveur d'exploration)

Nigrostriatal dopaminergic depletion increases static orofacial allodynia

Nigrostriatal dopaminergic depletion increases static orofacial allodynia

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	La maladie de Parkinson en France (serveur d'exploration)
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