Nigrostriatal dopaminergic depletion increases static orofacial allodynia
Identifieur interne : 000217 ( Main/Merge ); précédent : 000216; suivant : 000218Nigrostriatal dopaminergic depletion increases static orofacial allodynia
Auteurs : Wisam Dieb [France] ; Omar Ouachikh [France] ; Sofia Alves [France] ; Yves Boucher [France] ; Franck Durif [France] ; Aziz Hafidi [France]Source :
- The Journal of Headache and Pain [ 1129-2369 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Behavior, Animal, Constriction, Pathologic (complications), Disease Models, Animal, Dopamine (metabolism), Facial Pain (etiology), Facial Pain (metabolism), Hyperalgesia (etiology), Hyperalgesia (metabolism), Male, Neuralgia (etiology), Neuralgia (metabolism), Rats, Rats, Sprague-Dawley, Substantia Nigra (metabolism).
- MESH :
- chemical , metabolism : Dopamine.
- complications : Constriction, Pathologic.
- etiology : Facial Pain, Hyperalgesia, Neuralgia.
- metabolism : Facial Pain, Hyperalgesia, Neuralgia, Substantia Nigra.
- Animals, Behavior, Animal, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley.
Abstract
This study investigated mesencephalic dopamine depletion effects on static mechanical allodynia (SMA) elicited by chronic constriction of the infraorbitary nerve (CCI-IoN).
Dopamine depletion (6-OHDA administration into the medial forebrain bundle) effects on CCI-IoN-induced SMA were explored using behavioral (nocifensive behavior score upon non-noxious stimuli using von Frey filament), pharmacological (bromocriptine injections) and immunohistochemical (PKCγ and pERK1/2) techniques.
The central dopamine depletion increased significantly the SMA score. Intraperitoneal and intracisternal injections of bromocriptine alleviated the allodynic behavior observed in both CCI-IoN and CCI-IoN + 6-OHDA animal groups. At the cellular level, dopamine depletion induced a significant increase in PKCγ expression in the medullary dorsal horn (MDH) in rat with CCI-IoN + 6-OHDA when compared to sham animals (CCI-IoN only). Similarly, after static non-noxious stimuli, the expression of pain marker proteins pERK1/2 within the MDH revealed significantly a higher number of positive cells in CCI-IoN + 6-OHDA rats when compared to the CCI-IoN group.
This study demonstrates that nigrostriatal dopamine depletion exacerbates the neuropathic pain resulting from CCI-IoN. This effect is probably due to an action through descending pain inhibitory systems which increased pain sensitization at the MDH level. It demonstrates also an analgesic effect elicited by D2R activation at the segmental level.
The online version of this article (doi:10.1186/s10194-016-0607-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s10194-016-0607-z
PubMed: 26885825
PubMed Central: 4757596
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000240
- to stream Pmc, to step Curation: 000238
- to stream Pmc, to step Checkpoint: 000053
- to stream PubMed, to step Corpus: 000219
- to stream PubMed, to step Curation: 000218
- to stream PubMed, to step Checkpoint: 000218
- to stream Ncbi, to step Merge: 001955
- to stream Ncbi, to step Curation: 001955
- to stream Ncbi, to step Checkpoint: 001955
Links to Exploration step
PMC:4757596Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nigrostriatal dopaminergic depletion increases static orofacial allodynia</title>
<author><name sortKey="Dieb, Wisam" sort="Dieb, Wisam" uniqKey="Dieb W" first="Wisam" last="Dieb">Wisam Dieb</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UFR Odontologie, Université Paris Diderot, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UFR Odontologie, Université Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Psychiatrie et Neurosciences, INSERM U894, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ouachikh, Omar" sort="Ouachikh, Omar" uniqKey="Ouachikh O" first="Omar" last="Ouachikh">Omar Ouachikh</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alves, Sofia" sort="Alves, Sofia" uniqKey="Alves S" first="Sofia" last="Alves">Sofia Alves</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boucher, Yves" sort="Boucher, Yves" uniqKey="Boucher Y" first="Yves" last="Boucher">Yves Boucher</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UFR Odontologie, Université Paris Diderot, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UFR Odontologie, Université Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Psychiatrie et Neurosciences, INSERM U894, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">CHU Clermont-Ferrand, Service de Neurologie, 63000 Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Clermont-Ferrand, Service de Neurologie, 63000 Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hafidi, Aziz" sort="Hafidi, Aziz" uniqKey="Hafidi A" first="Aziz" last="Hafidi">Aziz Hafidi</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26885825</idno>
<idno type="pmc">4757596</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757596</idno>
<idno type="RBID">PMC:4757596</idno>
<idno type="doi">10.1186/s10194-016-0607-z</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000240</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000240</idno>
<idno type="wicri:Area/Pmc/Curation">000238</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000238</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000053</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000053</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000219</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000219</idno>
<idno type="wicri:Area/PubMed/Curation">000218</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000218</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000218</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000218</idno>
<idno type="wicri:Area/Ncbi/Merge">001955</idno>
<idno type="wicri:Area/Ncbi/Curation">001955</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001955</idno>
<idno type="wicri:doubleKey">1129-2369:2016:Dieb W:nigrostriatal:dopaminergic:depletion</idno>
<idno type="wicri:Area/Main/Merge">000217</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nigrostriatal dopaminergic depletion increases static orofacial allodynia</title>
<author><name sortKey="Dieb, Wisam" sort="Dieb, Wisam" uniqKey="Dieb W" first="Wisam" last="Dieb">Wisam Dieb</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UFR Odontologie, Université Paris Diderot, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UFR Odontologie, Université Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Psychiatrie et Neurosciences, INSERM U894, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ouachikh, Omar" sort="Ouachikh, Omar" uniqKey="Ouachikh O" first="Omar" last="Ouachikh">Omar Ouachikh</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alves, Sofia" sort="Alves, Sofia" uniqKey="Alves S" first="Sofia" last="Alves">Sofia Alves</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boucher, Yves" sort="Boucher, Yves" uniqKey="Boucher Y" first="Yves" last="Boucher">Yves Boucher</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UFR Odontologie, Université Paris Diderot, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UFR Odontologie, Université Paris Diderot, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Psychiatrie et Neurosciences, INSERM U894, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">CHU Clermont-Ferrand, Service de Neurologie, 63000 Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Clermont-Ferrand, Service de Neurologie, 63000 Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hafidi, Aziz" sort="Hafidi, Aziz" uniqKey="Hafidi A" first="Aziz" last="Hafidi">Aziz Hafidi</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clermont Université, Université d’Auvergne, EA7280, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Headache and Pain</title>
<idno type="ISSN">1129-2369</idno>
<idno type="eISSN">1129-2377</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Constriction, Pathologic (complications)</term>
<term>Disease Models, Animal</term>
<term>Dopamine (metabolism)</term>
<term>Facial Pain (etiology)</term>
<term>Facial Pain (metabolism)</term>
<term>Hyperalgesia (etiology)</term>
<term>Hyperalgesia (metabolism)</term>
<term>Male</term>
<term>Neuralgia (etiology)</term>
<term>Neuralgia (metabolism)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Substantia Nigra (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Constriction, Pathologic</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Facial Pain</term>
<term>Hyperalgesia</term>
<term>Neuralgia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Facial Pain</term>
<term>Hyperalgesia</term>
<term>Neuralgia</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>This study investigated mesencephalic dopamine depletion effects on static mechanical allodynia (SMA) elicited by chronic constriction of the infraorbitary nerve (CCI-IoN).</p>
</sec>
<sec><title>Methods</title>
<p>Dopamine depletion (6-OHDA administration into the medial forebrain bundle) effects on CCI-IoN-induced SMA were explored using behavioral (nocifensive behavior score upon non-noxious stimuli using von Frey filament), pharmacological (bromocriptine injections) and immunohistochemical (PKCγ and pERK1/2) techniques.</p>
</sec>
<sec><title>Results</title>
<p>The central dopamine depletion increased significantly the SMA score. Intraperitoneal and intracisternal injections of bromocriptine alleviated the allodynic behavior observed in both CCI-IoN and CCI-IoN + 6-OHDA animal groups. At the cellular level, dopamine depletion induced a significant increase in PKCγ expression in the medullary dorsal horn (MDH) in rat with CCI-IoN + 6-OHDA when compared to sham animals (CCI-IoN only). Similarly, after static non-noxious stimuli, the expression of pain marker proteins pERK1/2 within the MDH revealed significantly a higher number of positive cells in CCI-IoN + 6-OHDA rats when compared to the CCI-IoN group.</p>
</sec>
<sec><title>Conclusion</title>
<p>This study demonstrates that nigrostriatal dopamine depletion exacerbates the neuropathic pain resulting from CCI-IoN. This effect is probably due to an action through descending pain inhibitory systems which increased pain sensitization at the MDH level. It demonstrates also an analgesic effect elicited by D2R activation at the segmental level.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s10194-016-0607-z) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Benoliel, R" uniqKey="Benoliel R">R Benoliel</name>
</author>
<author><name sortKey="Zadik, Y" uniqKey="Zadik Y">Y Zadik</name>
</author>
<author><name sortKey="Eliav, E" uniqKey="Eliav E">E Eliav</name>
</author>
<author><name sortKey="Sharav, Y" uniqKey="Sharav Y">Y Sharav</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jensen, Ts" uniqKey="Jensen T">TS Jensen</name>
</author>
<author><name sortKey="Baron, R" uniqKey="Baron R">R Baron</name>
</author>
<author><name sortKey="Haanp, M" uniqKey="Haanp M">M Haanpää</name>
</author>
<author><name sortKey="Kalso, E" uniqKey="Kalso E">E Kalso</name>
</author>
<author><name sortKey="Loeser, Jd" uniqKey="Loeser J">JD Loeser</name>
</author>
<author><name sortKey="Rice, Asc" uniqKey="Rice A">ASC Rice</name>
</author>
<author><name sortKey="Treede, R D" uniqKey="Treede R">R-D Treede</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haviv, Y" uniqKey="Haviv Y">Y Haviv</name>
</author>
<author><name sortKey="Zadik, Y" uniqKey="Zadik Y">Y Zadik</name>
</author>
<author><name sortKey="Sharav, Y" uniqKey="Sharav Y">Y Sharav</name>
</author>
<author><name sortKey="Benoliel, R" uniqKey="Benoliel R">R Benoliel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iwata, K" uniqKey="Iwata K">K Iwata</name>
</author>
<author><name sortKey="Tsuboi, Y" uniqKey="Tsuboi Y">Y Tsuboi</name>
</author>
<author><name sortKey="Shima, A" uniqKey="Shima A">A Shima</name>
</author>
<author><name sortKey="Harada, T" uniqKey="Harada T">T Harada</name>
</author>
<author><name sortKey="Ren, K" uniqKey="Ren K">K Ren</name>
</author>
<author><name sortKey="Kanda, K" uniqKey="Kanda K">K Kanda</name>
</author>
<author><name sortKey="Kitagawa, J" uniqKey="Kitagawa J">J Kitagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okubo, M" uniqKey="Okubo M">M Okubo</name>
</author>
<author><name sortKey="Castro, A" uniqKey="Castro A">A Castro</name>
</author>
<author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name>
</author>
<author><name sortKey="Zou, S" uniqKey="Zou S">S Zou</name>
</author>
<author><name sortKey="Ren, K" uniqKey="Ren K">K Ren</name>
</author>
<author><name sortKey="Wei, F" uniqKey="Wei F">F Wei</name>
</author>
<author><name sortKey="Keller, A" uniqKey="Keller A">A Keller</name>
</author>
<author><name sortKey="Dubner, R" uniqKey="Dubner R">R Dubner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dauvergne, C" uniqKey="Dauvergne C">C Dauvergne</name>
</author>
<author><name sortKey="Molet, J" uniqKey="Molet J">J Molet</name>
</author>
<author><name sortKey="Reaux Le Goazigo, A" uniqKey="Reaux Le Goazigo A">A Reaux-Le Goazigo</name>
</author>
<author><name sortKey="Mauborgne, A" uniqKey="Mauborgne A">A Mauborgne</name>
</author>
<author><name sortKey="Melik Parsadaniantz, S" uniqKey="Melik Parsadaniantz S">S Mélik-Parsadaniantz</name>
</author>
<author><name sortKey="Boucher, Y" uniqKey="Boucher Y">Y Boucher</name>
</author>
<author><name sortKey="Pohl, M" uniqKey="Pohl M">M Pohl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wood, Pb" uniqKey="Wood P">PB Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cervenka, S" uniqKey="Cervenka S">S Cervenka</name>
</author>
<author><name sortKey="P Lhagen, Se" uniqKey="P Lhagen S">SE Pålhagen</name>
</author>
<author><name sortKey="Comley, Ra" uniqKey="Comley R">RA Comley</name>
</author>
<author><name sortKey="Panagiotidis, G" uniqKey="Panagiotidis G">G Panagiotidis</name>
</author>
<author><name sortKey="Cselenyi, Z" uniqKey="Cselenyi Z">Z Cselényi</name>
</author>
<author><name sortKey="Matthews, Jc" uniqKey="Matthews J">JC Matthews</name>
</author>
<author><name sortKey="Lai, Ry" uniqKey="Lai R">RY Lai</name>
</author>
<author><name sortKey="Halldin, C" uniqKey="Halldin C">C Halldin</name>
</author>
<author><name sortKey="Farde, L" uniqKey="Farde L">L Farde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, B" uniqKey="Ford B">B Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valkovic, P" uniqKey="Valkovic P">P Valkovic</name>
</author>
<author><name sortKey="Minar, M" uniqKey="Minar M">M Minar</name>
</author>
<author><name sortKey="Singliarova, H" uniqKey="Singliarova H">H Singliarova</name>
</author>
<author><name sortKey="Harsany, J" uniqKey="Harsany J">J Harsany</name>
</author>
<author><name sortKey="Hanakova, M" uniqKey="Hanakova M">M Hanakova</name>
</author>
<author><name sortKey="Martinkova, J" uniqKey="Martinkova J">J Martinkova</name>
</author>
<author><name sortKey="Benetin, J" uniqKey="Benetin J">J Benetin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ansah, Ob" uniqKey="Ansah O">OB Ansah</name>
</author>
<author><name sortKey="Leite Almeida, H" uniqKey="Leite Almeida H">H Leite-Almeida</name>
</author>
<author><name sortKey="Wei, H" uniqKey="Wei H">H Wei</name>
</author>
<author><name sortKey="Pertovaara, A" uniqKey="Pertovaara A">A Pertovaara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belforte, Je" uniqKey="Belforte J">JE Belforte</name>
</author>
<author><name sortKey="Pazo, Jh" uniqKey="Pazo J">JH Pazo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Ouachikh, O" uniqKey="Ouachikh O">O Ouachikh</name>
</author>
<author><name sortKey="Durif, F" uniqKey="Durif F">F Durif</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barcel, Ac" uniqKey="Barcel A">AC Barceló</name>
</author>
<author><name sortKey="Fillipini, B" uniqKey="Fillipini B">B Fillipini</name>
</author>
<author><name sortKey="Pazo, Jh" uniqKey="Pazo J">JH Pazo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Ouachikh, O" uniqKey="Ouachikh O">O Ouachikh</name>
</author>
<author><name sortKey="Durif, F" uniqKey="Durif F">F Durif</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vos, Bp" uniqKey="Vos B">BP Vos</name>
</author>
<author><name sortKey="Strassman, Am" uniqKey="Strassman A">AM Strassman</name>
</author>
<author><name sortKey="Maciewicz, Rj" uniqKey="Maciewicz R">RJ Maciewicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kernisant, M" uniqKey="Kernisant M">M Kernisant</name>
</author>
<author><name sortKey="Gear, Rw" uniqKey="Gear R">RW Gear</name>
</author>
<author><name sortKey="Jasmin, L" uniqKey="Jasmin L">L Jasmin</name>
</author>
<author><name sortKey="Vit, Jp" uniqKey="Vit J">JP Vit</name>
</author>
<author><name sortKey="Ohara, Pt" uniqKey="Ohara P">PT Ohara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malmberg, Ab" uniqKey="Malmberg A">AB Malmberg</name>
</author>
<author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name>
</author>
<author><name sortKey="Tonegawa, S" uniqKey="Tonegawa S">S Tonegawa</name>
</author>
<author><name sortKey="Basbaum, Ai" uniqKey="Basbaum A">AI Basbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakajima, A" uniqKey="Nakajima A">A Nakajima</name>
</author>
<author><name sortKey="Tsuboi, Y" uniqKey="Tsuboi Y">Y Tsuboi</name>
</author>
<author><name sortKey="Suzuki, I" uniqKey="Suzuki I">I Suzuki</name>
</author>
<author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name>
</author>
<author><name sortKey="Shinoda, M" uniqKey="Shinoda M">M Shinoda</name>
</author>
<author><name sortKey="Kondo, M" uniqKey="Kondo M">M Kondo</name>
</author>
<author><name sortKey="Matsuura, S" uniqKey="Matsuura S">S Matsuura</name>
</author>
<author><name sortKey="Shibuta, K" uniqKey="Shibuta K">K Shibuta</name>
</author>
<author><name sortKey="Yasuda, M" uniqKey="Yasuda M">M Yasuda</name>
</author>
<author><name sortKey="Shimizu, N" uniqKey="Shimizu N">N Shimizu</name>
</author>
<author><name sortKey="Iwata, K" uniqKey="Iwata K">K Iwata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, Rr" uniqKey="Ji R">RR Ji</name>
</author>
<author><name sortKey="Baba, H" uniqKey="Baba H">H Baba</name>
</author>
<author><name sortKey="Brenner, Gj" uniqKey="Brenner G">GJ Brenner</name>
</author>
<author><name sortKey="Woolf, Cj" uniqKey="Woolf C">CJ Woolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Alvarez, P" uniqKey="Alvarez P">P Alvarez</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouachikh, O" uniqKey="Ouachikh O">O Ouachikh</name>
</author>
<author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Durif, F" uniqKey="Durif F">F Durif</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamae, A" uniqKey="Tamae A">A Tamae</name>
</author>
<author><name sortKey="Nakatsuka, T" uniqKey="Nakatsuka T">T Nakatsuka</name>
</author>
<author><name sortKey="Koga, K" uniqKey="Koga K">K Koga</name>
</author>
<author><name sortKey="Kato, G" uniqKey="Kato G">G Kato</name>
</author>
<author><name sortKey="Furue, H" uniqKey="Furue H">H Furue</name>
</author>
<author><name sortKey="Katafuchi, T" uniqKey="Katafuchi T">T Katafuchi</name>
</author>
<author><name sortKey="Yoshimura, M" uniqKey="Yoshimura M">M Yoshimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taniguchi, W" uniqKey="Taniguchi W">W Taniguchi</name>
</author>
<author><name sortKey="Nakatsuka, T" uniqKey="Nakatsuka T">T Nakatsuka</name>
</author>
<author><name sortKey="Miyazaki, N" uniqKey="Miyazaki N">N Miyazaki</name>
</author>
<author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name>
</author>
<author><name sortKey="Takeda, D" uniqKey="Takeda D">D Takeda</name>
</author>
<author><name sortKey="Fujita, T" uniqKey="Fujita T">T Fujita</name>
</author>
<author><name sortKey="Kumamoto, E" uniqKey="Kumamoto E">E Kumamoto</name>
</author>
<author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dieb, W" uniqKey="Dieb W">W Dieb</name>
</author>
<author><name sortKey="Hafidi, A" uniqKey="Hafidi A">A Hafidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bergerot, A" uniqKey="Bergerot A">A Bergerot</name>
</author>
<author><name sortKey="Storer, Rj" uniqKey="Storer R">RJ Storer</name>
</author>
<author><name sortKey="Goadsby, Pj" uniqKey="Goadsby P">PJ Goadsby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chudler, Eh" uniqKey="Chudler E">EH Chudler</name>
</author>
<author><name sortKey="Dong, Wk" uniqKey="Dong W">WK Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Magnusson, Je" uniqKey="Magnusson J">JE Magnusson</name>
</author>
<author><name sortKey="Fisher, K" uniqKey="Fisher K">K Fisher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saade, Ne" uniqKey="Saade N">NE Saadé</name>
</author>
<author><name sortKey="Atweh, Sf" uniqKey="Atweh S">SF Atweh</name>
</author>
<author><name sortKey="Bahuth, Nb" uniqKey="Bahuth N">NB Bahuth</name>
</author>
<author><name sortKey="Jabbur, Sj" uniqKey="Jabbur S">SJ Jabbur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takeda, R" uniqKey="Takeda R">R Takeda</name>
</author>
<author><name sortKey="Ikeda, T" uniqKey="Ikeda T">T Ikeda</name>
</author>
<author><name sortKey="Tsuda, F" uniqKey="Tsuda F">F Tsuda</name>
</author>
<author><name sortKey="Abe, H" uniqKey="Abe H">H Abe</name>
</author>
<author><name sortKey="Hashiguchi, H" uniqKey="Hashiguchi H">H Hashiguchi</name>
</author>
<author><name sortKey="Ishida, Y" uniqKey="Ishida Y">Y Ishida</name>
</author>
<author><name sortKey="Nishimori, T" uniqKey="Nishimori T">T Nishimori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Millan, Mj" uniqKey="Millan M">MJ Millan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, Pj" uniqKey="Meyer P">PJ Meyer</name>
</author>
<author><name sortKey="Morgan, Mm" uniqKey="Morgan M">MM Morgan</name>
</author>
<author><name sortKey="Kozell, Lb" uniqKey="Kozell L">LB Kozell</name>
</author>
<author><name sortKey="Ingram, Sl" uniqKey="Ingram S">SL Ingram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chieng, B" uniqKey="Chieng B">B Chieng</name>
</author>
<author><name sortKey="Christie, Mj" uniqKey="Christie M">MJ Christie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirouac, Gj" uniqKey="Kirouac G">GJ Kirouac</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
<author><name sortKey="Mabrouk, G" uniqKey="Mabrouk G">G Mabrouk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hokfelt, T" uniqKey="Hokfelt T">T Hökfelt</name>
</author>
<author><name sortKey="Phillipson, O" uniqKey="Phillipson O">O Phillipson</name>
</author>
<author><name sortKey="Goldstein, M" uniqKey="Goldstein M">M Goldstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malmierca, E" uniqKey="Malmierca E">E Malmierca</name>
</author>
<author><name sortKey="Martin, Yb" uniqKey="Martin Y">YB Martin</name>
</author>
<author><name sortKey="Nu Ez, A" uniqKey="Nu Ez A">A Nuñez</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000217 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000217 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:4757596 |texte= Nigrostriatal dopaminergic depletion increases static orofacial allodynia }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:26885825" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |