Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
Identifieur interne : 000166 ( Main/Merge ); précédent : 000165; suivant : 000167Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
Auteurs : Michel Engeln [France] ; Matthieu F. Bastide [France] ; Estelle Toulmé [France] ; Benjamin Dehay [France] ; Mathieu Bourdenx [France] ; Evelyne Doudnikoff [France] ; Qin Li [République populaire de Chine] ; Christian E. Gross [France] ; Eric Boué-Grabot [France] ; Antonio Pisani [Italie] ; Erwan Bezard [France] ; Pierre-Olivier Fernagut [France]Source :
- Biological psychiatry [ 1873-2402 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antiparkinson Agents (adverse effects), Daunorubicin (administration & dosage), Daunorubicin (analogs & derivatives), Disease Models, Animal, Dyskinesia, Drug-Induced (drug therapy), Levodopa (adverse effects), Macaca fascicularis, Male, Neostriatum (drug effects), Neurons (drug effects), Oxidopamine (administration & dosage), Parkinson Disease (complications), Patch-Clamp Techniques, Proto-Oncogene Proteins c-fos (metabolism), Rats, Rats, Sprague-Dawley, Receptors, Dopamine D1 (metabolism).
- MESH :
- chemical , administration & dosage : Daunorubicin, Oxidopamine.
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , analogs & derivatives : Daunorubicin.
- complications : Parkinson Disease.
- drug effects : Neostriatum, Neurons.
- drug therapy : Dyskinesia, Drug-Induced.
- chemical , metabolism : Proto-Oncogene Proteins c-fos, Receptors, Dopamine D1.
- Animals, Disease Models, Animal, Macaca fascicularis, Male, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley.
Abstract
ΔFosB is a surrogate marker of L-DOPA-induced dyskinesia (LID), the unavoidable disabling consequence of Parkinson's disease L-DOPA long-term treatment. However, the relationship between the electrical activity of FosB/ΔFosB-expressing neurons and LID manifestation is unknown.
DOI: 10.1016/j.biopsych.2014.07.007
PubMed: 25146322
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pubmed:25146322Le document en format XML
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neostriatum</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proto-Oncogene Proteins c-fos</term>
<term>Receptors, Dopamine D1</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Macaca fascicularis</term>
<term>Male</term>
<term>Patch-Clamp Techniques</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">ΔFosB is a surrogate marker of L-DOPA-induced dyskinesia (LID), the unavoidable disabling consequence of Parkinson's disease L-DOPA long-term treatment. However, the relationship between the electrical activity of FosB/ΔFosB-expressing neurons and LID manifestation is unknown.</div>
</front>
</TEI>
</record>
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