Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia
Identifieur interne : 004167 ( Main/Exploration ); précédent : 004166; suivant : 004168Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia
Auteurs : O. Rascol [France] ; U. Sabatini [France, Italie] ; C. Brefel [France] ; N. Fabre [France] ; S. Rai [France] ; J. M. Senard [France] ; P. Celsis [France] ; G. Viallard [France] ; J. L. Montastruc [France] ; F. Chollet [France]Source :
- Brain [ 0006-8950 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Antiparkinson agent, Cerebrovascular Circulation (physiology), Chemotherapy, Comparative study, Dyskinesia, Dyskinesia, Drug-Induced (diagnostic imaging), Dyskinesia, Drug-Induced (physiopathology), Emission tomography, Humans, Levodopa, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Motor Cortex (diagnostic imaging), Motor Cortex (physiopathology), Motor cortex, Multivariate Analysis, Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Pathophysiology, Photon, Reference Values, Regional blood flow, Tomography, Emission-Computed, Single-Photon, Toxicity, Treatment.
- MESH :
- chemical , adverse effects : Levodopa.
- diagnostic imaging : Dyskinesia, Drug-Induced, Motor Cortex, Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiology : Cerebrovascular Circulation.
- physiopathology : Dyskinesia, Drug-Induced, Motor Cortex, Parkinson Disease.
- chemical , therapeutic use : Levodopa.
- Aged, Analysis of Variance, Humans, Male, Middle Aged, Multivariate Analysis, Reference Values, Tomography, Emission-Computed, Single-Photon.
Abstract
We have studied the regional cerebral blood flow (rCBF) changes induced by the execution of a finger-to-thumb opposition motor task in the supplementary and primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa induced dyskinesia (n = 23) and the other with moderate peak-dose dyskinesia (n = 15 ), and ofa group of 14 normal subjects. Single photon emission tomography with i.v. 133Xe was used to measure the rCBF changes. The dyskinetic pa rkinsonian patients exhibited a pattern of response which was markedly different from those of the normal subjects and non-dyskinetic parkinsonian patients, with a significant overactivation in the supplementary motor area and the ipsi- and contralateral primary motor areas. These results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhibition of the primary and associated motor cortex secondary to an excessive outflow of the pallidothalamocortical motor loop.
Affiliations:
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Rascol</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Istituto di Neurosienze</s1><s2>Pozzilli</s2><s3>ITA</s3><sZ>2 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Istituto di Neurosienze</wicri:noRegion></affiliation></author><author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C." last="Brefel">C. Brefel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N." last="Fabre">N. Fabre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neurological Departments, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Neurological Departments, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Rai, S" sort="Rai, S" uniqKey="Rai S" first="S." last="Rai">S. Rai</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neurological Departments, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Neurological Departments, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J. M." last="Senard">J. M. Senard</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Viallard, G" sort="Viallard, G" uniqKey="Viallard G" first="G." last="Viallard">G. Viallard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J. L." last="Montastruc">J. L. Montastruc</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Medical and Clinical Pharmacology Department, University Hospital of Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U455, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>INSERM U455, University Hospital of Toulouse</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neurological Departments, University Hospital of Toulouse</s1><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital of Toulouse</wicri:noRegion><wicri:noRegion>Neurological Departments, University Hospital of Toulouse</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Antiparkinson agent</term><term>Cerebrovascular Circulation (physiology)</term><term>Chemotherapy</term><term>Comparative study</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (diagnostic imaging)</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Emission tomography</term><term>Humans</term><term>Levodopa</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (diagnostic imaging)</term><term>Motor Cortex (physiopathology)</term><term>Motor cortex</term><term>Multivariate Analysis</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Photon</term><term>Reference Values</term><term>Regional blood flow</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Toxicity</term><term>Treatment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Reference Values</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Parkinson maladie</term><term>Débit sanguin régional</term><term>Lévodopa</term><term>Chimiothérapie</term><term>Antiparkinsonien</term><term>Tomoscintigraphie</term><term>Photon</term><term>Cortex moteur</term><term>Etude comparative</term><term>Traitement</term><term>Toxicité</term><term>Physiopathologie</term><term>Mâle</term><term>Adulte</term><term>Aire motrice supplémentaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have studied the regional cerebral blood flow (rCBF) changes induced by the execution of a finger-to-thumb opposition motor task in the supplementary and primary motor cortex of two groups of parkinsonian patients on L-dopa medication, the first one without L-dopa induced dyskinesia (n = 23) and the other with moderate peak-dose dyskinesia (n = 15 ), and ofa group of 14 normal subjects. Single photon emission tomography with i.v. <sup>133</sup>Xe was used to measure the rCBF changes. The dyskinetic pa rkinsonian patients exhibited a pattern of response which was markedly different from those of the normal subjects and non-dyskinetic parkinsonian patients, with a significant overactivation in the supplementary motor area and the ipsi- and contralateral primary motor areas. These results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhibition of the primary and associated motor cortex secondary to an excessive outflow of the pallidothalamocortical motor loop.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li></country></list><tree><country name="France"><noRegion><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name></noRegion><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C." last="Brefel">C. Brefel</name><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C." last="Brefel">C. Brefel</name><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N." last="Fabre">N. Fabre</name><name sortKey="Fabre, N" sort="Fabre, N" uniqKey="Fabre N" first="N." last="Fabre">N. Fabre</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J. L." last="Montastruc">J. L. Montastruc</name><name sortKey="Rai, S" sort="Rai, S" uniqKey="Rai S" first="S." last="Rai">S. Rai</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J. M." last="Senard">J. M. Senard</name><name sortKey="Viallard, G" sort="Viallard, G" uniqKey="Viallard G" first="G." last="Viallard">G. Viallard</name></country><country name="Italie"><noRegion><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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