A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey
Identifieur interne : 004459 ( Main/Exploration ); précédent : 004458; suivant : 004460A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey
Auteurs : E. Bezard [France] ; C. Imbert [France] ; X. Deloire [France] ; B. Bioulac [France] ; C. E. Gross [France]Source :
- Brain research [ 0006-8993 ] ; 1997.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animal model, Animals, Antiparkinson Agents (pharmacology), Cell Count, Chronic, Chronic Disease, Disease Models, Animal, Disease Progression, Dopamine Agents, Levodopa (pharmacology), Macaca fascicularis, Monkey, Movement (physiology), Neurons (cytology), Neurons (enzymology), Neurotoxin, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (physiopathology), Parkinson disease, Tyrosine 3-Monooxygenase (analysis).
- MESH :
- chemical , analysis : Tyrosine 3-Monooxygenase.
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Dopamine Agents.
- chemically induced : Parkinson Disease, Secondary.
- cytology : Neurons.
- drug therapy : Parkinson Disease, Secondary.
- enzymology : Neurons.
- physiology : Movement.
- physiopathology : Parkinson Disease, Secondary.
- Animals, Cell Count, Chronic Disease, Disease Models, Animal, Disease Progression, Macaca fascicularis.
Abstract
Copyright (c) 1997 Elsevier Science B.V. All rights reserved. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to induce parkinsonism both in man and non-human primates. Several models have now been developed, but acute MPTP administration does not consistently reproduce all the clinical features of the disease. To mirror the slow evolution observed in human pathology, a chronic model of intoxication is necessary. The present study describes a chronic MPTP protocol in the monkey. Six monkeys received daily injections of MPTP (0.2 mg/kg i.v.) until they reached a score over 8 on the clinical rating scale (15.5 days±1.1). Full parkinsonism was first obtained on the 22nd day. Levodopa testing (20 mg/kg per os) alleviated motor abnormalities (51%), proving the parkinsonian nature of these disturbances. Histological lesions reproduced those observed in Parkinson's disease with a decrease in tyrosine hydroxylase immunoreactivity of 90%. This model so could be of great interest for the study of the dynamic physiopathological changes which occur in Parkinson's disease and consequently for research on new neuroprotective therapies.
Affiliations:
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Gross</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, 146 rue Leo Saignat, 33076 Cedex</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animal model</term><term>Animals</term><term>Antiparkinson Agents (pharmacology)</term><term>Cell Count</term><term>Chronic</term><term>Chronic Disease</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Dopamine Agents</term><term>Levodopa (pharmacology)</term><term>Macaca fascicularis</term><term>Monkey</term><term>Movement (physiology)</term><term>Neurons (cytology)</term><term>Neurons (enzymology)</term><term>Neurotoxin</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson disease</term><term>Tyrosine 3-Monooxygenase (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Chronic Disease</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Macaca fascicularis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Neurotoxine</term><term>Modèle animal</term><term>Chronique</term><term>Parkinson maladie</term><term>Singe</term><term>MPTP</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Copyright (c) 1997 Elsevier Science B.V. All rights reserved. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to induce parkinsonism both in man and non-human primates. Several models have now been developed, but acute MPTP administration does not consistently reproduce all the clinical features of the disease. To mirror the slow evolution observed in human pathology, a chronic model of intoxication is necessary. The present study describes a chronic MPTP protocol in the monkey. Six monkeys received daily injections of MPTP (0.2 mg/kg i.v.) until they reached a score over 8 on the clinical rating scale (15.5 days±1.1). Full parkinsonism was first obtained on the 22nd day. Levodopa testing (20 mg/kg per os) alleviated motor abnormalities (51%), proving the parkinsonian nature of these disturbances. Histological lesions reproduced those observed in Parkinson's disease with a decrease in tyrosine hydroxylase immunoreactivity of 90%. This model so could be of great interest for the study of the dynamic physiopathological changes which occur in Parkinson's disease and consequently for research on new neuroprotective therapies.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E." last="Bezard">E. Bezard</name></region><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name><name sortKey="Deloire, X" sort="Deloire, X" uniqKey="Deloire X" first="X." last="Deloire">X. Deloire</name><name sortKey="Gross, C E" sort="Gross, C E" uniqKey="Gross C" first="C. E." last="Gross">C. E. Gross</name><name sortKey="Imbert, C" sort="Imbert, C" uniqKey="Imbert C" first="C." last="Imbert">C. 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