ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:8149366

Apomorphine and diphasic dyskinesia.

Identifieur interne : 004921 ( Main/Exploration ); précédent : 004920; suivant : 004922

Apomorphine and diphasic dyskinesia.

Auteurs : F. Durif [France] ; D. Deffond ; G. Dordain ; M. Tournilhac

Source :

Clinical neuropharmacology [ 0362-5664 ] ; 1994.

RBID : pubmed:8149366

English descriptors

KwdEn :
- Aged, Apomorphine (therapeutic use), Circadian Rhythm (physiology), Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Female, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy).
MESH :
- chemical , adverse effects : Levodopa.
- chemical , therapeutic use : Apomorphine, Levodopa.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- physiology : Circadian Rhythm.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. Apomorphine was effective in reducing the duration of diphasic dyskinesias at doses higher than the threshold doses necessary to induce an "on" phase (mean increase: 43%). However, after a few months of treatment, apomorphine was ineffective in stopping abnormal movements, even when doses were increased. In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon. Acute diurnal variations of the pharmacodynamic striatal response are suggested explanation for these clinical observations.

PubMed: 8149366

Affiliations:

France

Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Clinique Neurologique, Hôpital Fontamaure, CHU Clermont-Ferrand, Chamalières, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Hôpital Fontamaure, CHU Clermont-Ferrand, Chamalières</wicri:regionArea>
<wicri:noRegion>Chamalières</wicri:noRegion>
<wicri:noRegion>Chamalières</wicri:noRegion>
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<author><name sortKey="Deffond, D" sort="Deffond, D" uniqKey="Deffond D" first="D" last="Deffond">D. Deffond</name>
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<author><name sortKey="Dordain, G" sort="Dordain, G" uniqKey="Dordain G" first="G" last="Dordain">G. Dordain</name>
</author>
<author><name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name>
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<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Apomorphine</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
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<front><div type="abstract" xml:lang="en">We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. Apomorphine was effective in reducing the duration of diphasic dyskinesias at doses higher than the threshold doses necessary to induce an "on" phase (mean increase: 43%). However, after a few months of treatment, apomorphine was ineffective in stopping abnormal movements, even when doses were increased. In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon. Acute diurnal variations of the pharmacodynamic striatal response are suggested explanation for these clinical observations.</div>
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<name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name>
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<country name="France"><noRegion><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name>
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La maladie de Parkinson en France (serveur d'exploration)

Apomorphine and diphasic dyskinesia.

Apomorphine and diphasic dyskinesia.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.