Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum
Identifieur interne : 004B89 ( Main/Exploration ); précédent : 004B88; suivant : 004B90Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum
Auteurs : M. T. Herrero [France] ; E. C. Hirsch [France] ; F. Javoy-Agid [France] ; J. A. Obeso [Espagne] ; Yves Agid [France]Source :
- Brain Research [ 0006-8993 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animal model, Animals, Cell Count (drug effects), Choline O-Acetyltransferase (metabolism), Choline acetyltransferase, Cholinergic neuron, Dopamine (metabolism), Dopaminergic neuron, Immunohistochemistry, Laterodorsal tegmental nucleus, MPTP, Macaca fascicularis, Monkey, Neurons (drug effects), Neurons (metabolism), Parasympathetic Nervous System (cytology), Parasympathetic Nervous System (drug effects), Parkinson Disease, Secondary (chemically induced), Parkinson disease, Pedunculopontine nucleus, Pons, Tegmentum, Tegmentum Mesencephali (cytology), Tegmentum Mesencephali (drug effects), Tegmentum Mesencephali (metabolism), Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Choline O-Acetyltransferase, Dopamine, Tyrosine 3-Monooxygenase.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinson Disease, Secondary.
- cytology : Parasympathetic Nervous System, Tegmentum Mesencephali.
- drug effects : Cell Count, Neurons, Parasympathetic Nervous System, Tegmentum Mesencephali.
- metabolism : Neurons, Tegmentum Mesencephali.
- Animals, Immunohistochemistry, Macaca fascicularis, Pons.
Abstract
Abstract: Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dopaminergic neurons, in the mesopontine tegmentum cholinergic neurons are preserved in the same region. This suggests that the loss of mesopontine cholinergic neurons in parkinsonian patients may represent an end-stage degenerative process, the cause of which may be independent of the mechanism of dopaminergic cell death.
Url:
DOI: 10.1016/0006-8993(93)90088-5
Affiliations:
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Le document en format XML
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<term>Animals</term>
<term>Cell Count (drug effects)</term>
<term>Choline O-Acetyltransferase (metabolism)</term>
<term>Choline acetyltransferase</term>
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<term>Dopamine (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Abstract: Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dopaminergic neurons, in the mesopontine tegmentum cholinergic neurons are preserved in the same region. This suggests that the loss of mesopontine cholinergic neurons in parkinsonian patients may represent an end-stage degenerative process, the cause of which may be independent of the mechanism of dopaminergic cell death.</div>
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