ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:7902770

Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum

Identifieur interne : 004B89 ( Main/Exploration ); précédent : 004B88; suivant : 004B90

Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum

Auteurs : M. T. Herrero [France] ; E. C. Hirsch [France] ; F. Javoy-Agid [France] ; J. A. Obeso [Espagne] ; Yves Agid [France]

Source :

Brain Research [ 0006-8993 ] ; 1993.

RBID : ISTEX:F454066903C7B6F5061399AA6D0870400443185F

Descripteurs français

Pascal (Inist)
- Choline acetyltransferase, MPTP, Macaca fascicularis, Modèle animal, Neurone cholinergique, Neurone dopaminergique, Parkinson maladie, Singe, Tegmentum.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animal model, Animals, Cell Count (drug effects), Choline O-Acetyltransferase (metabolism), Choline acetyltransferase, Cholinergic neuron, Dopamine (metabolism), Dopaminergic neuron, Immunohistochemistry, Laterodorsal tegmental nucleus, MPTP, Macaca fascicularis, Monkey, Neurons (drug effects), Neurons (metabolism), Parasympathetic Nervous System (cytology), Parasympathetic Nervous System (drug effects), Parkinson Disease, Secondary (chemically induced), Parkinson disease, Pedunculopontine nucleus, Pons, Tegmentum, Tegmentum Mesencephali (cytology), Tegmentum Mesencephali (drug effects), Tegmentum Mesencephali (metabolism), Tyrosine 3-Monooxygenase (metabolism).
MESH :
- chemical , metabolism : Choline O-Acetyltransferase, Dopamine, Tyrosine 3-Monooxygenase.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinson Disease, Secondary.
- cytology : Parasympathetic Nervous System, Tegmentum Mesencephali.
- drug effects : Cell Count, Neurons, Parasympathetic Nervous System, Tegmentum Mesencephali.
- metabolism : Neurons, Tegmentum Mesencephali.
- Animals, Immunohistochemistry, Macaca fascicularis, Pons.

Abstract

Abstract: Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dopaminergic neurons, in the mesopontine tegmentum cholinergic neurons are preserved in the same region. This suggests that the loss of mesopontine cholinergic neurons in parkinsonian patients may represent an end-stage degenerative process, the cause of which may be independent of the mechanism of dopaminergic cell death.

Url:

https://api.istex.fr/document/F454066903C7B6F5061399AA6D0870400443185F/fulltext/pdf

DOI: 10.1016/0006-8993(93)90088-5

Affiliations:

Le document en format XML

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<term>Choline acetyltransferase</term>
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<front><div type="abstract" xml:lang="en">Abstract: Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dopaminergic neurons, in the mesopontine tegmentum cholinergic neurons are preserved in the same region. This suggests that the loss of mesopontine cholinergic neurons in parkinsonian patients may represent an end-stage degenerative process, the cause of which may be independent of the mechanism of dopaminergic cell death.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum

Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	La maladie de Parkinson en France (serveur d'exploration)
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