Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease
Identifieur interne : 004885 ( Main/Exploration ); précédent : 004884; suivant : 004886Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease
Auteurs : P. Ryvlin [France] ; E. Broussolle [France] ; H. Piollet [France] ; F. Viallet [France] ; YAD KHALFALLAH [France] ; G. Chazot [France]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 1995.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (metabolism), Basal Ganglia (pathology), Basal ganglion, Concentration, Exploration, Female, Human, Humans, Idiopathic, Iron, Iron (metabolism), Magnetic Resonance Imaging, Male, Middle Aged, Nuclear magnetic resonance imaging, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson disease, Prospective Studies, Putamen (metabolism), Putamen (pathology).
- MESH :
- chemical , metabolism : Iron.
- diagnosis : Parkinson Disease.
- metabolism : Basal Ganglia, Parkinson Disease, Putamen.
- pathology : Basal Ganglia, Putamen.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies.
Abstract
Objective: To determine the changes in basal ganglia iron content associated with various stages of idiopathic Parkinson's disease. Design: Prospective magnetic resonance imaging study using a 2-T magnet. Setting: Ambulatory care referral center. Patients and Participants: Forty-five patients suffering from levodopa-responsive Parkinson's disease and 45 age-matched controls. Main Outcomes Measures: The T2 relaxation time calculated in various regions of the basal ganglia, the duration of Parkinson's disease, and the age of subjects. Results: Patients with Parkinson's disease exhibited significantly decreased T2 relaxation time in the pars compactq of the substantia nigra compared with controls (P<.01), regardless of disease duration. Patients with a duration of illness above 10 years (n= 1 2) exhibited significantly increased T2 relaxation time in the anterior and posterior putamen (P<.005 and P<.01, respectively) andin the pallidum (P<.05) compared with age-matched controls. Putamenal T2 relaxation time positively correlated with disease duration (P<.05), Conclusion: These results suggest that more complex brain iron changes than those previously reported are associated with idiopathic Parkinson's disease, including increased nigral iron content and decreased putamenal and pallidal iron concentration in patients with a duration of illness above 10 years
Affiliations:
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Ryvlin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôp. neurologique, dep. neurology</s1><s2>Lyon 69003</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôp. neurologique, dep. neurology</s1><s2>Lyon 69003</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Piollet, H" sort="Piollet, H" uniqKey="Piollet H" first="H." last="Piollet">H. Piollet</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Clin. Ste Catherine, magnetic resonance imaging dep.</s1><s2>Avignon</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F." last="Viallet">F. Viallet</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Cent. hosp. gén., dep. neurology</s1><s2>Aix-en-Provence</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Yad Khalfallah" sort="Yad Khalfallah" uniqKey="Yad Khalfallah" last="Yad Khalfallah">YAD KHALFALLAH</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM Fac. Alexis Carrel, U197 lab. exp. medicine</s1><s2>Lyon</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Chazot, G" sort="Chazot, G" uniqKey="Chazot G" first="G." last="Chazot">G. Chazot</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôp. neurologique, dep. neurology</s1><s2>Lyon 69003</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Basal Ganglia (metabolism)</term><term>Basal Ganglia (pathology)</term><term>Basal ganglion</term><term>Concentration</term><term>Exploration</term><term>Female</term><term>Human</term><term>Humans</term><term>Idiopathic</term><term>Iron</term><term>Iron (metabolism)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson disease</term><term>Prospective Studies</term><term>Putamen (metabolism)</term><term>Putamen (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Idiopathique</term><term>Imagerie RMN</term><term>Noyau gris central</term><term>Fer</term><term>Concentration</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Fer</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine the changes in basal ganglia iron content associated with various stages of idiopathic Parkinson's disease. Design: Prospective magnetic resonance imaging study using a 2-T magnet. Setting: Ambulatory care referral center. Patients and Participants: Forty-five patients suffering from levodopa-responsive Parkinson's disease and 45 age-matched controls. Main Outcomes Measures: The T<sub>2</sub> relaxation time calculated in various regions of the basal ganglia, the duration of Parkinson's disease, and the age of subjects. Results: Patients with Parkinson's disease exhibited significantly decreased T<sub>2</sub> relaxation time in the pars compactq of the substantia nigra compared with controls (P<.01), regardless of disease duration. Patients with a duration of illness above 10 years (n= 1 2) exhibited significantly increased T<sub>2</sub> relaxation time in the anterior and posterior putamen (P<.005 and P<.01, respectively) andin the pallidum (P<.05) compared with age-matched controls. Putamenal T<sub>2</sub> relaxation time positively correlated with disease duration (P<.05), Conclusion: These results suggest that more complex brain iron changes than those previously reported are associated with idiopathic Parkinson's disease, including increased nigral iron content and decreased putamenal and pallidal iron concentration in patients with a duration of illness above 10 years</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li></region><settlement><li>Aix-en-Provence</li><li>Avignon</li><li>Lyon</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ryvlin, P" sort="Ryvlin, P" uniqKey="Ryvlin P" first="P." last="Ryvlin">P. Ryvlin</name></region><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><name sortKey="Chazot, G" sort="Chazot, G" uniqKey="Chazot G" first="G." last="Chazot">G. Chazot</name><name sortKey="Piollet, H" sort="Piollet, H" uniqKey="Piollet H" first="H." last="Piollet">H. Piollet</name><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F." last="Viallet">F. Viallet</name><name sortKey="Yad Khalfallah" sort="Yad Khalfallah" uniqKey="Yad Khalfallah" last="Yad Khalfallah">YAD KHALFALLAH</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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