Clinical trial of Madopar HBS in parkinsonian patients with fluctuating drug response after long-term levodopa therapy.
Identifieur interne : 005347 ( Main/Exploration ); précédent : 005346; suivant : 005348Clinical trial of Madopar HBS in parkinsonian patients with fluctuating drug response after long-term levodopa therapy.
Auteurs : P. Rondot [France] ; M. Ziegler ; N. Aymard ; J. HolzerSource :
- European neurology [ 0014-3022 ] ; 1987.
English descriptors
- KwdEn :
- Aged, Benserazide (pharmacokinetics), Benserazide (therapeutic use), Clinical Trials as Topic, Delayed-Action Preparations, Drug Combinations (pharmacokinetics), Drug Combinations (therapeutic use), Female, Humans, Hydrazines (therapeutic use), Levodopa (blood), Levodopa (pharmacokinetics), Levodopa (therapeutic use), Male, Middle Aged, Movement Disorders (drug therapy), Movement Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Time Factors.
- MESH :
- chemical , blood : Levodopa.
- chemical , pharmacokinetics : Benserazide, Drug Combinations, Levodopa.
- chemical , therapeutic use : Benserazide, Drug Combinations, Hydrazines, Levodopa.
- complications : Parkinson Disease.
- drug therapy : Movement Disorders, Parkinson Disease.
- etiology : Movement Disorders.
- physiopathology : Parkinson Disease.
- Aged, Clinical Trials as Topic, Delayed-Action Preparations, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
23 parkinsonian patients, 11 men and 12 women with an average age of 62 +/- 10 years, were recruited for an open substitution study of standard Madopar by Madopar HBS (hydrodynamically balanced system). All patients were presenting fluctuations in efficacy associated or not with abnormal involuntary movements. The patients in this study had been suffering from Parkinson's disease for 16 +/- 6 years and were severely disabled (Hoehn and Yahr grade III-V). The substitution was carried out dose for dose from one day to another. During the first month the dosage titration was aimed at finding the optimal therapeutic effect. After 120 days 13 patients were continuing the treatment while 10 had stopped it because of lack of therapeutic advantage. After 120 days, as compared to the initial state, end-of-dose fluctuations improved by 47%, the parkinsonian symptomatology by 54% and the abnormal involuntary movements improved by 33%. The daily dose of Levodopa had to be increased from 580 +/- 230 to 710 +/- 240 mg. The results obtained were excellent in 5 cases, good in 6 and moderate in 2 cases.
PubMed: 3322835
Affiliations:
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Aymard</name></author><author><name sortKey="Holzer, J" sort="Holzer, J" uniqKey="Holzer J" first="J" last="Holzer">J. 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Rondot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, Hôpital Sainte-Anne, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hôpital Sainte-Anne, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ziegler, M" sort="Ziegler, M" uniqKey="Ziegler M" first="M" last="Ziegler">M. Ziegler</name></author><author><name sortKey="Aymard, N" sort="Aymard, N" uniqKey="Aymard N" first="N" last="Aymard">N. Aymard</name></author><author><name sortKey="Holzer, J" sort="Holzer, J" uniqKey="Holzer J" first="J" last="Holzer">J. Holzer</name></author></analytic><series><title level="j">European neurology</title><idno type="ISSN">0014-3022</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Benserazide (pharmacokinetics)</term><term>Benserazide (therapeutic use)</term><term>Clinical Trials as Topic</term><term>Delayed-Action Preparations</term><term>Drug Combinations (pharmacokinetics)</term><term>Drug Combinations (therapeutic use)</term><term>Female</term><term>Humans</term><term>Hydrazines (therapeutic use)</term><term>Levodopa (blood)</term><term>Levodopa (pharmacokinetics)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (drug therapy)</term><term>Movement Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Benserazide</term><term>Drug Combinations</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Benserazide</term><term>Drug Combinations</term><term>Hydrazines</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Clinical Trials as Topic</term><term>Delayed-Action Preparations</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">23 parkinsonian patients, 11 men and 12 women with an average age of 62 +/- 10 years, were recruited for an open substitution study of standard Madopar by Madopar HBS (hydrodynamically balanced system). All patients were presenting fluctuations in efficacy associated or not with abnormal involuntary movements. The patients in this study had been suffering from Parkinson's disease for 16 +/- 6 years and were severely disabled (Hoehn and Yahr grade III-V). The substitution was carried out dose for dose from one day to another. During the first month the dosage titration was aimed at finding the optimal therapeutic effect. After 120 days 13 patients were continuing the treatment while 10 had stopped it because of lack of therapeutic advantage. After 120 days, as compared to the initial state, end-of-dose fluctuations improved by 47%, the parkinsonian symptomatology by 54% and the abnormal involuntary movements improved by 33%. The daily dose of Levodopa had to be increased from 580 +/- 230 to 710 +/- 240 mg. The results obtained were excellent in 5 cases, good in 6 and moderate in 2 cases.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Aymard, N" sort="Aymard, N" uniqKey="Aymard N" first="N" last="Aymard">N. Aymard</name><name sortKey="Holzer, J" sort="Holzer, J" uniqKey="Holzer J" first="J" last="Holzer">J. Holzer</name><name sortKey="Ziegler, M" sort="Ziegler, M" uniqKey="Ziegler M" first="M" last="Ziegler">M. Ziegler</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Rondot, P" sort="Rondot, P" uniqKey="Rondot P" first="P" last="Rondot">P. Rondot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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