Extrapyramidal and cognitive signs in amyotrophic lateral sclerosis: A population based cross-sectional study.
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Extrapyramidal and cognitive signs in amyotrophic lateral sclerosis: A population based cross-sectional study.
Auteurs : Elisabetta Pupillo [Italie] ; Elisa Bianchi [Italie] ; Paolo Messina [Italie] ; Luca Chiveri [Italie] ; Christian Lunetta [Italie] ; Massimo Corbo [Italie] ; Massimiliano Filosto [Italie] ; Lorenzo Lorusso [Italie] ; Benoit Marin [France] ; Jessica Mandrioli [Italie] ; Nilo Riva [Italie] ; Francesco Sasanelli [Italie] ; Lucio Tremolizzo [Italie] ; Ettore Beghi [Italie]Source :
- Amyotrophic lateral sclerosis & frontotemporal degeneration [ 2167-9223 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis (complications), Amyotrophic Lateral Sclerosis (epidemiology), Amyotrophic Lateral Sclerosis (psychology), Basal Ganglia Diseases (etiology), Case-Control Studies, Cognition Disorders (etiology), Community Health Planning, Cross-Sectional Studies, Female, Humans, Male, Mental Status Schedule, Middle Aged, Multivariate Analysis.
- MESH :
- complications : Amyotrophic Lateral Sclerosis.
- epidemiology : Amyotrophic Lateral Sclerosis.
- etiology : Basal Ganglia Diseases, Cognition Disorders.
- psychology : Amyotrophic Lateral Sclerosis.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Community Health Planning, Cross-Sectional Studies, Female, Humans, Male, Mental Status Schedule, Middle Aged, Multivariate Analysis.
Abstract
Our objective was to assess the association between amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD) and Parkinson's disease (PD). From May 2007 through August 2012 we investigated 146 patients with newly diagnosed ALS and 146 age- and gender-matched controls. Each individual was screened for cardinal extrapyramidal signs (neurological examination) and cognitive dysfunction (Mini Mental State Examination, MMSE and Frontal Assessment Battery, FAB). Results demonstrated that rigidity was present in 8.2% of cases and 2.1% of controls (adjusted odds ratio, adjOR 5.7; 95% CI 1.5-22.0). The corresponding percentages for bradykinesia and postural instability were, respectively, 8.2 vs. 2.7% (adjOR 4.8; 95% CI 1.4-16.5) and 2.7 vs. 9.6% (adjOR 0.3; 95% CI 0.1-0.9). FAB ≤ 13.4 was recorded in 24.8 vs. 9.6%; adjOR 2.9; 95% CI 1.5-5.7). Tremor and abnormal FAB score were predicted by an older age at onset while an abnormal FAB score was associated with cramps and family history of neurodegenerative diseases. In conclusion, our data support the notion that newly diagnosed ALS carries a higher than expected risk of extrapyramidal signs and FTD.
DOI: 10.3109/21678421.2015.1040028
PubMed: 25967544
Affiliations:
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Le document en format XML
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Mellino Mellini, Chiari , Brescia , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>f U.O. di Neurologia, A.O. 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xml:lang="fr">Italie</country><wicri:regionArea>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25967544</idno><idno type="pmid">25967544</idno><idno type="doi">10.3109/21678421.2015.1040028</idno><idno type="wicri:Area/PubMed/Corpus">000416</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000416</idno><idno type="wicri:Area/PubMed/Curation">000410</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000410</idno><idno type="wicri:Area/PubMed/Checkpoint">000410</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000410</idno><idno type="wicri:Area/Ncbi/Merge">001708</idno><idno type="wicri:Area/Ncbi/Curation">001708</idno><idno 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sort="Bianchi, Elisa" uniqKey="Bianchi E" first="Elisa" last="Bianchi">Elisa Bianchi</name><affiliation wicri:level="1"><nlm:affiliation>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Messina, Paolo" sort="Messina, Paolo" uniqKey="Messina P" first="Paolo" last="Messina">Paolo Messina</name><affiliation wicri:level="1"><nlm:affiliation>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Chiveri, Luca" sort="Chiveri, Luca" uniqKey="Chiveri L" first="Luca" last="Chiveri">Luca Chiveri</name><affiliation wicri:level="1"><nlm:affiliation>b Ospedale Valduce , Como , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>b Ospedale Valduce , Como </wicri:regionArea><wicri:noRegion>Como </wicri:noRegion></affiliation></author><author><name sortKey="Lunetta, Christian" sort="Lunetta, Christian" uniqKey="Lunetta C" first="Christian" last="Lunetta">Christian Lunetta</name><affiliation wicri:level="1"><nlm:affiliation>c Centro Clinico NEMO, Fondazione Serena Onlus , Milano , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>c Centro Clinico NEMO, Fondazione Serena Onlus , Milano </wicri:regionArea><wicri:noRegion>Milano </wicri:noRegion></affiliation></author><author><name sortKey="Corbo, Massimo" sort="Corbo, Massimo" uniqKey="Corbo M" first="Massimo" last="Corbo">Massimo Corbo</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Neurorehabilitation Sciences , Casa Cura Policlinico , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>d Department of Neurorehabilitation Sciences , Casa Cura Policlinico , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Filosto, Massimiliano" sort="Filosto, Massimiliano" uniqKey="Filosto M" first="Massimiliano" last="Filosto">Massimiliano Filosto</name><affiliation wicri:level="1"><nlm:affiliation>e Spedali Civili di Brescia , Brescia , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>e Spedali Civili di Brescia , Brescia </wicri:regionArea><wicri:noRegion>Brescia </wicri:noRegion></affiliation></author><author><name sortKey="Lorusso, Lorenzo" sort="Lorusso, Lorenzo" uniqKey="Lorusso L" first="Lorenzo" last="Lorusso">Lorenzo Lorusso</name><affiliation wicri:level="1"><nlm:affiliation>f U.O. di Neurologia, A.O. Mellino Mellini, Chiari , Brescia , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>f U.O. di Neurologia, A.O. Mellino Mellini, Chiari , Brescia </wicri:regionArea><wicri:noRegion>Brescia </wicri:noRegion></affiliation></author><author><name sortKey="Marin, Benoit" sort="Marin, Benoit" uniqKey="Marin B" first="Benoit" last="Marin">Benoit Marin</name><affiliation wicri:level="1"><nlm:affiliation>g INSERM UMR1094, Tropical Neuroepidemiology , Limoges , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>g INSERM UMR1094, Tropical Neuroepidemiology , Limoges </wicri:regionArea><wicri:noRegion>Limoges </wicri:noRegion><wicri:noRegion>Limoges </wicri:noRegion></affiliation></author><author><name sortKey="Mandrioli, Jessica" sort="Mandrioli, Jessica" uniqKey="Mandrioli J" first="Jessica" last="Mandrioli">Jessica Mandrioli</name><affiliation wicri:level="1"><nlm:affiliation>h Sant'Agostino-Estense' Hospital, University of Modena and Reggio Emilia , Modena , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>h Sant'Agostino-Estense' Hospital, University of Modena and Reggio Emilia , Modena </wicri:regionArea><wicri:noRegion>Modena </wicri:noRegion></affiliation></author><author><name sortKey="Riva, Nilo" sort="Riva, Nilo" uniqKey="Riva N" first="Nilo" last="Riva">Nilo Riva</name><affiliation wicri:level="1"><nlm:affiliation>i Department of Neurology and Institute of Experimental Neurology (INSPE) , IRCCS San Raffaele Scientific Institute , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>i Department of Neurology and Institute of Experimental Neurology (INSPE) , IRCCS San Raffaele Scientific Institute , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Sasanelli, Francesco" sort="Sasanelli, Francesco" uniqKey="Sasanelli F" first="Francesco" last="Sasanelli">Francesco Sasanelli</name><affiliation wicri:level="1"><nlm:affiliation>j Azienda Ospedaliera di Melegnano, Vizzolo Predabissi , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>j Azienda Ospedaliera di Melegnano, Vizzolo Predabissi , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Tremolizzo, Lucio" sort="Tremolizzo, Lucio" uniqKey="Tremolizzo L" first="Lucio" last="Tremolizzo">Lucio Tremolizzo</name><affiliation wicri:level="1"><nlm:affiliation>k Ospedale San Gerardo, Monza, University of Milano-Bicocca , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>k Ospedale San Gerardo, Monza, University of Milano-Bicocca </wicri:regionArea><wicri:noRegion>University of Milano-Bicocca </wicri:noRegion></affiliation></author><author><name sortKey="Beghi, Ettore" sort="Beghi, Ettore" uniqKey="Beghi E" first="Ettore" last="Beghi">Ettore Beghi</name><affiliation wicri:level="1"><nlm:affiliation>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>a Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri' , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author></analytic><series><title level="j">Amyotrophic lateral sclerosis & frontotemporal degeneration</title><idno type="eISSN">2167-9223</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Amyotrophic Lateral Sclerosis (complications)</term><term>Amyotrophic Lateral Sclerosis (epidemiology)</term><term>Amyotrophic Lateral Sclerosis (psychology)</term><term>Basal Ganglia Diseases (etiology)</term><term>Case-Control Studies</term><term>Cognition Disorders (etiology)</term><term>Community Health Planning</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Multivariate Analysis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Community Health Planning</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Multivariate Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our objective was to assess the association between amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD) and Parkinson's disease (PD). From May 2007 through August 2012 we investigated 146 patients with newly diagnosed ALS and 146 age- and gender-matched controls. Each individual was screened for cardinal extrapyramidal signs (neurological examination) and cognitive dysfunction (Mini Mental State Examination, MMSE and Frontal Assessment Battery, FAB). Results demonstrated that rigidity was present in 8.2% of cases and 2.1% of controls (adjusted odds ratio, adjOR 5.7; 95% CI 1.5-22.0). The corresponding percentages for bradykinesia and postural instability were, respectively, 8.2 vs. 2.7% (adjOR 4.8; 95% CI 1.4-16.5) and 2.7 vs. 9.6% (adjOR 0.3; 95% CI 0.1-0.9). FAB ≤ 13.4 was recorded in 24.8 vs. 9.6%; adjOR 2.9; 95% CI 1.5-5.7). Tremor and abnormal FAB score were predicted by an older age at onset while an abnormal FAB score was associated with cramps and family history of neurodegenerative diseases. In conclusion, our data support the notion that newly diagnosed ALS carries a higher than expected risk of extrapyramidal signs and FTD.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Pupillo, Elisabetta" sort="Pupillo, Elisabetta" uniqKey="Pupillo E" first="Elisabetta" last="Pupillo">Elisabetta Pupillo</name></noRegion><name sortKey="Beghi, Ettore" sort="Beghi, Ettore" uniqKey="Beghi E" first="Ettore" last="Beghi">Ettore Beghi</name><name sortKey="Bianchi, Elisa" sort="Bianchi, Elisa" uniqKey="Bianchi E" first="Elisa" last="Bianchi">Elisa Bianchi</name><name sortKey="Chiveri, Luca" sort="Chiveri, Luca" uniqKey="Chiveri L" first="Luca" last="Chiveri">Luca Chiveri</name><name sortKey="Corbo, Massimo" sort="Corbo, Massimo" uniqKey="Corbo M" first="Massimo" last="Corbo">Massimo Corbo</name><name sortKey="Filosto, Massimiliano" sort="Filosto, Massimiliano" uniqKey="Filosto M" first="Massimiliano" last="Filosto">Massimiliano Filosto</name><name sortKey="Lorusso, Lorenzo" sort="Lorusso, Lorenzo" uniqKey="Lorusso L" first="Lorenzo" last="Lorusso">Lorenzo Lorusso</name><name sortKey="Lunetta, Christian" sort="Lunetta, Christian" uniqKey="Lunetta C" first="Christian" last="Lunetta">Christian Lunetta</name><name sortKey="Mandrioli, Jessica" sort="Mandrioli, Jessica" uniqKey="Mandrioli J" first="Jessica" last="Mandrioli">Jessica Mandrioli</name><name sortKey="Messina, Paolo" sort="Messina, Paolo" uniqKey="Messina P" first="Paolo" last="Messina">Paolo Messina</name><name sortKey="Riva, Nilo" sort="Riva, Nilo" uniqKey="Riva N" first="Nilo" last="Riva">Nilo Riva</name><name sortKey="Sasanelli, Francesco" sort="Sasanelli, Francesco" uniqKey="Sasanelli F" first="Francesco" last="Sasanelli">Francesco Sasanelli</name><name sortKey="Tremolizzo, Lucio" sort="Tremolizzo, Lucio" uniqKey="Tremolizzo L" first="Lucio" last="Tremolizzo">Lucio Tremolizzo</name></country><country name="France"><noRegion><name sortKey="Marin, Benoit" sort="Marin, Benoit" uniqKey="Marin B" first="Benoit" last="Marin">Benoit Marin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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