Tendon rupture as an adverse effect of rasagiline.
Identifieur interne : 005941 ( Main/Exploration ); précédent : 005940; suivant : 005942Tendon rupture as an adverse effect of rasagiline.
Auteurs : Romain Lefaucheur [France] ; Damien Fetter ; Gaëlle Gaillon ; Alaina Borden ; David MaltêteSource :
- Clinical neuropharmacology [ 1537-162X ]
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Indans, Monoamine Oxidase Inhibitors.
- chemically induced : Rupture, Spontaneous, Tendon Injuries.
- Aged, Female, Humans.
Abstract
A 66-year-old woman with advanced Parkinson disease (PD) was referred to our center for an adjustment of her antiparkinsonian medication. To reduce daily off-time, we introduced rasagiline 1 mg/d. Three days after starting this new treatment, she presented with intense arthralgia that symmetrically affected the shoulders, hands, and hips without myalgia. Ten days later, while walking, she experienced acute pain on the inner side of her right thigh, with the absence of any trauma. Findings of ultrasonography confirming the diagnosis of partial avulsion of the right harmstrings. Rasagiline was stopped immediately, and the arthralgia disappeared within 48 hours and did not recur. To our knowledge, this is the first reported case of a spontaneous tendon rupture possibly caused by rasagiline. Our observation emphasizes that, although often well tolerated, rasagiline may cause muscle and joint complications that could increase disability in patients with PD.
DOI: 10.1097/WNF.0000000000000023
PubMed: 24614673
Affiliations:
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Le document en format XML
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last="Fetter">Damien Fetter</name></author><author><name sortKey="Gaillon, Gaelle" sort="Gaillon, Gaelle" uniqKey="Gaillon G" first="Gaëlle" last="Gaillon">Gaëlle Gaillon</name></author><author><name sortKey="Borden, Alaina" sort="Borden, Alaina" uniqKey="Borden A" first="Alaina" last="Borden">Alaina Borden</name></author><author><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2014 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:24614673</idno><idno type="pmid">24614673</idno><idno type="doi">10.1097/WNF.0000000000000023</idno><idno type="wicri:Area/PubMed/Corpus">000600</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000600</idno><idno type="wicri:Area/PubMed/Curation">000578</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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xml:lang="fr">France</country><wicri:regionArea>Departments of *Neurology, †Pharmacology, Rouen University Hospital, University of Rouen, and ‡Faculty of Medicine, University of Rouen, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Fetter, Damien" sort="Fetter, Damien" uniqKey="Fetter D" first="Damien" last="Fetter">Damien Fetter</name></author><author><name sortKey="Gaillon, Gaelle" sort="Gaillon, Gaelle" uniqKey="Gaillon G" first="Gaëlle" last="Gaillon">Gaëlle Gaillon</name></author><author><name sortKey="Borden, Alaina" sort="Borden, Alaina" uniqKey="Borden A" first="Alaina" last="Borden">Alaina Borden</name></author><author><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name></author></analytic><series><title level="j">Clinical neuropharmacology</title><idno type="eISSN">1537-162X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Indans (adverse effects)</term><term>Monoamine Oxidase Inhibitors (adverse effects)</term><term>Rupture, Spontaneous (chemically induced)</term><term>Tendon Injuries (chemically induced)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Indans</term><term>Monoamine Oxidase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Rupture, Spontaneous</term><term>Tendon Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 66-year-old woman with advanced Parkinson disease (PD) was referred to our center for an adjustment of her antiparkinsonian medication. To reduce daily off-time, we introduced rasagiline 1 mg/d. Three days after starting this new treatment, she presented with intense arthralgia that symmetrically affected the shoulders, hands, and hips without myalgia. Ten days later, while walking, she experienced acute pain on the inner side of her right thigh, with the absence of any trauma. Findings of ultrasonography confirming the diagnosis of partial avulsion of the right harmstrings. Rasagiline was stopped immediately, and the arthralgia disappeared within 48 hours and did not recur. To our knowledge, this is the first reported case of a spontaneous tendon rupture possibly caused by rasagiline. Our observation emphasizes that, although often well tolerated, rasagiline may cause muscle and joint complications that could increase disability in patients with PD.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Rouen</li></settlement></list><tree><noCountry><name sortKey="Borden, Alaina" sort="Borden, Alaina" uniqKey="Borden A" first="Alaina" last="Borden">Alaina Borden</name><name sortKey="Fetter, Damien" sort="Fetter, Damien" uniqKey="Fetter D" first="Damien" last="Fetter">Damien Fetter</name><name sortKey="Gaillon, Gaelle" sort="Gaillon, Gaelle" uniqKey="Gaillon G" first="Gaëlle" last="Gaillon">Gaëlle Gaillon</name><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Lefaucheur, Romain" sort="Lefaucheur, Romain" uniqKey="Lefaucheur R" first="Romain" last="Lefaucheur">Romain Lefaucheur</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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