[Infectious properties of protein aggregates involved in neurodegenerative diseases].
Identifieur interne : 000B89 ( Main/Exploration ); précédent : 000B88; suivant : 000B90[Infectious properties of protein aggregates involved in neurodegenerative diseases].
Auteurs : Luc Bousset [France] ; Ronald MelkiSource :
- Biologie aujourd'hui [ 2105-0686 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Proteins.
- metabolism : Neurodegenerative Diseases.
- Cell Communication, Humans, Protein Folding, Protein Multimerization.
Abstract
Several progressive neurodegenerative disorders, e.g. Alzheimer, Parkinson and Huntington diseases, cerebro-spinal ataxia and amyotrophic lateral sclerosis, are the consequence of protein misfolding and aggregation. Recent data indicates that some of these diseases are not cell autonomous as previously thought. We and others have shown that protein assemblies involved in the aforementioned diseases propagate from cell to cell in a manner akin prion high molecular weight assemblies propagation in Creutzfeldt-Jacob disease. The mechanism of propagation and amplification of protein assemblies involved in neurodegenerative diseases and its physiopathological consequences are discussed hereafter.
Url:
DOI: 10.1051/jbio/2013004
PubMed: 23694725
Affiliations:
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Le document en format XML
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Recent data indicates that some of these diseases are not cell autonomous as previously thought. We and others have shown that protein assemblies involved in the aforementioned diseases propagate from cell to cell in a manner akin prion high molecular weight assemblies propagation in Creutzfeldt-Jacob disease. The mechanism of propagation and amplification of protein assemblies involved in neurodegenerative diseases and its physiopathological consequences are discussed hereafter.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Gif-sur-Yvette</li></settlement></list><tree><noCountry><name sortKey="Melki, Ronald" sort="Melki, Ronald" uniqKey="Melki R" first="Ronald" last="Melki">Ronald Melki</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Bousset, Luc" sort="Bousset, Luc" uniqKey="Bousset L" first="Luc" last="Bousset">Luc Bousset</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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