Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.
Identifieur interne : 000C98 ( Main/Exploration ); précédent : 000C97; suivant : 000C99Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.
Auteurs : Lukasz Szyrwiel [France] ; J Zsef S. Pap ; Wieslaw Malinka ; Zbigniew Szewczuk ; Aleksandra Kotynia ; Justyna BrasunSource :
- Journal of pharmaceutical and biomedical analysis [ 1873-264X ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Copper, Iron, Zinc.
- chemical , pharmacology : Antiparkinson Agents, Benserazide, Levodopa.
- chemical : Drug Combinations.
- methods : Mass Spectrometry, Spectrophotometry, Ultraviolet.
Abstract
One of the treatments of Parkinson disease is based on increasing the brain dopamine level by L-DOPA (LD) applications. To prevent the peripheral degradation of levodopa, another drug, benserazide is applied. On the other hand, during this neurodegenerative disease changes in the homeostasis of metals are observed and the increasing brain zinc levels are postulated to have therapeutic effects. Here we present studies on interactions of Zn(II), Cu(II), Fe(II) ions with benserazide and with benserazide/levodopa in ternary system. By applying mass spectrometry and UV-vis methods we describe the interactions between selected metal ions and the drug additives in the investigated systems. The results show forming of equimolar complexes in the binary and ternary systems.
DOI: 10.1016/j.jpba.2012.11.032
PubMed: 23291441
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000758
- to stream PubMed, to step Curation: 000725
- to stream PubMed, to step Checkpoint: 000725
- to stream Ncbi, to step Merge: 001046
- to stream Ncbi, to step Curation: 001046
- to stream Ncbi, to step Checkpoint: 001046
- to stream Main, to step Merge: 000D22
- to stream Main, to step Curation: 000C98
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.</title>
<author><name sortKey="Szyrwiel, Lukasz" sort="Szyrwiel, Lukasz" uniqKey="Szyrwiel L" first="Lukasz" last="Szyrwiel">Lukasz Szyrwiel</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Chemistry of Drugs, Wrocław Medical University, ul. Borowska 211, 50-552 Wrocław, Poland; CNRS/UPPA, LCABIE, UMR5254, Hélioparc, 2, av. Pr. Angot, F-64053 Pau, France. lukasz.szyrwiel@am.wroc.pl</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Chemistry of Drugs, Wrocław Medical University, ul. Borowska 211, 50-552 Wrocław, Poland; CNRS/UPPA, LCABIE, UMR5254, Hélioparc, 2, av. Pr. Angot, F-64053 Pau</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Pau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pap, J Zsef S" sort="Pap, J Zsef S" uniqKey="Pap J" first="J Zsef S" last="Pap">J Zsef S. Pap</name>
</author>
<author><name sortKey="Malinka, Wieslaw" sort="Malinka, Wieslaw" uniqKey="Malinka W" first="Wieslaw" last="Malinka">Wieslaw Malinka</name>
</author>
<author><name sortKey="Szewczuk, Zbigniew" sort="Szewczuk, Zbigniew" uniqKey="Szewczuk Z" first="Zbigniew" last="Szewczuk">Zbigniew Szewczuk</name>
</author>
<author><name sortKey="Kotynia, Aleksandra" sort="Kotynia, Aleksandra" uniqKey="Kotynia A" first="Aleksandra" last="Kotynia">Aleksandra Kotynia</name>
</author>
<author><name sortKey="Brasun, Justyna" sort="Brasun, Justyna" uniqKey="Brasun J" first="Justyna" last="Brasun">Justyna Brasun</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23291441</idno>
<idno type="pmid">23291441</idno>
<idno type="doi">10.1016/j.jpba.2012.11.032</idno>
<idno type="wicri:Area/PubMed/Corpus">000758</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000758</idno>
<idno type="wicri:Area/PubMed/Curation">000725</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000725</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000725</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000725</idno>
<idno type="wicri:Area/Ncbi/Merge">001046</idno>
<idno type="wicri:Area/Ncbi/Curation">001046</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001046</idno>
<idno type="wicri:Area/Main/Merge">000D22</idno>
<idno type="wicri:Area/Main/Curation">000C98</idno>
<idno type="wicri:Area/Main/Exploration">000C98</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.</title>
<author><name sortKey="Szyrwiel, Lukasz" sort="Szyrwiel, Lukasz" uniqKey="Szyrwiel L" first="Lukasz" last="Szyrwiel">Lukasz Szyrwiel</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Chemistry of Drugs, Wrocław Medical University, ul. Borowska 211, 50-552 Wrocław, Poland; CNRS/UPPA, LCABIE, UMR5254, Hélioparc, 2, av. Pr. Angot, F-64053 Pau, France. lukasz.szyrwiel@am.wroc.pl</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Chemistry of Drugs, Wrocław Medical University, ul. Borowska 211, 50-552 Wrocław, Poland; CNRS/UPPA, LCABIE, UMR5254, Hélioparc, 2, av. Pr. Angot, F-64053 Pau</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Pau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pap, J Zsef S" sort="Pap, J Zsef S" uniqKey="Pap J" first="J Zsef S" last="Pap">J Zsef S. Pap</name>
</author>
<author><name sortKey="Malinka, Wieslaw" sort="Malinka, Wieslaw" uniqKey="Malinka W" first="Wieslaw" last="Malinka">Wieslaw Malinka</name>
</author>
<author><name sortKey="Szewczuk, Zbigniew" sort="Szewczuk, Zbigniew" uniqKey="Szewczuk Z" first="Zbigniew" last="Szewczuk">Zbigniew Szewczuk</name>
</author>
<author><name sortKey="Kotynia, Aleksandra" sort="Kotynia, Aleksandra" uniqKey="Kotynia A" first="Aleksandra" last="Kotynia">Aleksandra Kotynia</name>
</author>
<author><name sortKey="Brasun, Justyna" sort="Brasun, Justyna" uniqKey="Brasun J" first="Justyna" last="Brasun">Justyna Brasun</name>
</author>
</analytic>
<series><title level="j">Journal of pharmaceutical and biomedical analysis</title>
<idno type="eISSN">1873-264X</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (pharmacology)</term>
<term>Benserazide (pharmacology)</term>
<term>Copper (metabolism)</term>
<term>Drug Combinations</term>
<term>Iron (metabolism)</term>
<term>Levodopa (pharmacology)</term>
<term>Mass Spectrometry (methods)</term>
<term>Spectrophotometry, Ultraviolet (methods)</term>
<term>Zinc (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Copper</term>
<term>Iron</term>
<term>Zinc</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Benserazide</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mass Spectrometry</term>
<term>Spectrophotometry, Ultraviolet</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">One of the treatments of Parkinson disease is based on increasing the brain dopamine level by L-DOPA (LD) applications. To prevent the peripheral degradation of levodopa, another drug, benserazide is applied. On the other hand, during this neurodegenerative disease changes in the homeostasis of metals are observed and the increasing brain zinc levels are postulated to have therapeutic effects. Here we present studies on interactions of Zn(II), Cu(II), Fe(II) ions with benserazide and with benserazide/levodopa in ternary system. By applying mass spectrometry and UV-vis methods we describe the interactions between selected metal ions and the drug additives in the investigated systems. The results show forming of equimolar complexes in the binary and ternary systems.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
</region>
<settlement><li>Pau</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Brasun, Justyna" sort="Brasun, Justyna" uniqKey="Brasun J" first="Justyna" last="Brasun">Justyna Brasun</name>
<name sortKey="Kotynia, Aleksandra" sort="Kotynia, Aleksandra" uniqKey="Kotynia A" first="Aleksandra" last="Kotynia">Aleksandra Kotynia</name>
<name sortKey="Malinka, Wieslaw" sort="Malinka, Wieslaw" uniqKey="Malinka W" first="Wieslaw" last="Malinka">Wieslaw Malinka</name>
<name sortKey="Pap, J Zsef S" sort="Pap, J Zsef S" uniqKey="Pap J" first="J Zsef S" last="Pap">J Zsef S. Pap</name>
<name sortKey="Szewczuk, Zbigniew" sort="Szewczuk, Zbigniew" uniqKey="Szewczuk Z" first="Zbigniew" last="Szewczuk">Zbigniew Szewczuk</name>
</noCountry>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Szyrwiel, Lukasz" sort="Szyrwiel, Lukasz" uniqKey="Szyrwiel L" first="Lukasz" last="Szyrwiel">Lukasz Szyrwiel</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C98 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C98 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:23291441 |texte= Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23291441" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |