Evaluation of the safety and tolerability of rasagiline in the treatment of the early stages of Parkinson's disease.
Identifieur interne : 000D27 ( Main/Exploration ); précédent : 000D26; suivant : 000D28Evaluation of the safety and tolerability of rasagiline in the treatment of the early stages of Parkinson's disease.
Auteurs : François Viallet [France] ; Séverine Pitel ; Sylvie Lancrenon ; Olivier BlinSource :
- Current medical research and opinion [ 1473-4877 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Benzothiazoles (administration & dosage), Benzothiazoles (adverse effects), Double-Blind Method, Female, Gastrointestinal Diseases (chemically induced), Humans, Indans (administration & dosage), Indans (adverse effects), Male, Middle Aged, Monoamine Oxidase Inhibitors (administration & dosage), Monoamine Oxidase Inhibitors (adverse effects), Parkinson Disease (drug therapy), Sleep Wake Disorders (chemically induced), Time Factors.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Benzothiazoles, Indans, Monoamine Oxidase Inhibitors.
- chemical , adverse effects : Antiparkinson Agents, Benzothiazoles, Indans, Monoamine Oxidase Inhibitors.
- chemically induced : Gastrointestinal Diseases, Sleep Wake Disorders.
- drug therapy : Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
Rasagiline is a second-generation, irreversible MAO-B inhibitor (MAOB-I) previously shown to be efficacious and well-tolerated compared to placebo in the treatment of early Parkinson's disease (PD). ACTOR (ACceptabilité TOlérance Rasagiline) was a 15-week, multi-center, randomized, double-blind study aimed to assess the safety and tolerability of rasagiline compared to the dopaminergic agonist pramipexole in the treatment of early PD.
DOI: 10.1185/03007995.2012.752351
PubMed: 23176073
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Rasagiline is a second-generation, irreversible MAO-B inhibitor (MAOB-I) previously shown to be efficacious and well-tolerated compared to placebo in the treatment of early Parkinson's disease (PD). ACTOR (ACceptabilité TOlérance Rasagiline) was a 15-week, multi-center, randomized, double-blind study aimed to assess the safety and tolerability of rasagiline compared to the dopaminergic agonist pramipexole in the treatment of early PD.</div>
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