Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.
Identifieur interne : 001A30 ( Main/Exploration ); précédent : 001A29; suivant : 001A31Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.
Auteurs : Suzanne Lesage [France] ; Christel Condroyer ; Ebba Lohman ; André Troiano ; François Tison ; François Viallet ; Philippe Damier ; Christine Tranchant ; Marie Vidhaillet ; Anne-Marie Ouvrard-Hernandez ; Alexandra Dürr ; Alexis BriceSource :
- Neurobiology of aging [ 1558-1497 ] ; 2010.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Carrier Proteins.
- geographic : France.
- genetics : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Family Health, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Young Adult.
Abstract
Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.
DOI: 10.1016/j.neurobiolaging.2009.06.008
PubMed: 20004041
Affiliations:
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uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name></author><author><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name></author><author><name sortKey="Vidhaillet, Marie" sort="Vidhaillet, Marie" uniqKey="Vidhaillet M" first="Marie" last="Vidhaillet">Marie Vidhaillet</name></author><author><name sortKey="Ouvrard Hernandez, Anne Marie" sort="Ouvrard Hernandez, Anne Marie" uniqKey="Ouvrard Hernandez A" first="Anne-Marie" last="Ouvrard-Hernandez">Anne-Marie Ouvrard-Hernandez</name></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Carrier Proteins (genetics)</term><term>Family Health</term><term>Female</term><term>Follow-Up Studies</term><term>France</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Family Health</term><term>Female</term><term>Follow-Up Studies</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Condroyer, Christel" sort="Condroyer, Christel" uniqKey="Condroyer C" first="Christel" last="Condroyer">Christel Condroyer</name><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><name sortKey="Lohman, Ebba" sort="Lohman, Ebba" uniqKey="Lohman E" first="Ebba" last="Lohman">Ebba Lohman</name><name sortKey="Ouvrard Hernandez, Anne Marie" sort="Ouvrard Hernandez, Anne Marie" uniqKey="Ouvrard Hernandez A" first="Anne-Marie" last="Ouvrard-Hernandez">Anne-Marie Ouvrard-Hernandez</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><name sortKey="Troiano, Andre" sort="Troiano, Andre" uniqKey="Troiano A" first="André" last="Troiano">André Troiano</name><name sortKey="Viallet, Francois" sort="Viallet, Francois" uniqKey="Viallet F" first="François" last="Viallet">François Viallet</name><name sortKey="Vidhaillet, Marie" sort="Vidhaillet, Marie" uniqKey="Vidhaillet M" first="Marie" last="Vidhaillet">Marie Vidhaillet</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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