New electrophysiological mapping combined with MRI in parkinsonian’s subthalamic region
Identifieur interne : 002057 ( Main/Exploration ); précédent : 002056; suivant : 002058New electrophysiological mapping combined with MRI in parkinsonian’s subthalamic region
Auteurs : J. Coste [France] ; L. Ouchchane [France] ; L. Sarry [France] ; P. Derost [France] ; F. Durif [France] ; J. Gabrillargues [France] ; S. Hemm [France] ; J. J. Lemaire [France]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2009-04.
English descriptors
- KwdEn :
- Action Potentials (physiology), Aged, Brain Mapping (methods), Deep Brain Stimulation (methods), Electrophysiology, Female, Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Neurons (physiology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson’s disease, Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (pathology), Subthalamic Nucleus (physiology), deep brain stimulation, electrophysiology, spontaneous activity, subthalamic nucleus.
- MESH :
- anatomy & histology : Subthalamic Nucleus.
- methods : Brain Mapping, Deep Brain Stimulation, Magnetic Resonance Imaging.
- pathology : Parkinson Disease, Subthalamic Nucleus.
- physiology : Action Potentials, Neurons, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Electrophysiology, Female, Humans, Male, Middle Aged.
Abstract
The subthalamic nucleus (STN) is the main target for deep brain stimulation in Parkinson’s disease. We analysed the relationships between magnetic resonance imaging (MRI) anatomy and spontaneous neuronal activity to confirm the potential of microelectrode recordings to assist in determining the optimal surgical target. Ten bilateral surgeries were performed after 1.5‐T (T2‐weighted) anatomical MRI identification of the STN, zona incerta (ZI), Forel’s field H2 (H2) and substantia nigra (SN). Spontaneous neuronal activity was recorded simultaneously along the distal 10 mm on a central track (optimally covering the STN) and a 2‐mm anterior track. We calculated off‐line mean firing rate and burst frequency on 248 neurons clustered according to anatomical structure. Subjective visual analysis of signal was also realized on‐line, during surgery, to classify patterns of activity. Mean firing rate and burst frequency increased from H2–ZI to SN. The mean firing rate was higher in SN only using paired comparison (SN vs. its neighbours). The burst frequency was lower in H2 than in SN; using comparison with neighbours, it was lower in H2 and ZI. An irregular high activity (type 2C) was more often detected in STN and SN than in H2 and ZI. Anatomical boundaries and unitary recordings appear to be linked, supporting the ability of MRI to provide a detailed anatomy. Electrophysiological mapping combined with MRI is a useful tool for precise targeting in the subthalamic region.
Url:
DOI: 10.1111/j.1460-9568.2009.06698.x
Affiliations:
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We analysed the relationships between magnetic resonance imaging (MRI) anatomy and spontaneous neuronal activity to confirm the potential of microelectrode recordings to assist in determining the optimal surgical target. Ten bilateral surgeries were performed after 1.5‐T (T2‐weighted) anatomical MRI identification of the STN, zona incerta (ZI), Forel’s field H2 (H2) and substantia nigra (SN). Spontaneous neuronal activity was recorded simultaneously along the distal 10 mm on a central track (optimally covering the STN) and a 2‐mm anterior track. We calculated off‐line mean firing rate and burst frequency on 248 neurons clustered according to anatomical structure. Subjective visual analysis of signal was also realized on‐line, during surgery, to classify patterns of activity. Mean firing rate and burst frequency increased from H2–ZI to SN. The mean firing rate was higher in SN only using paired comparison (SN vs. its neighbours). The burst frequency was lower in H2 than in SN; using comparison with neighbours, it was lower in H2 and ZI. An irregular high activity (type 2C) was more often detected in STN and SN than in H2 and ZI. Anatomical boundaries and unitary recordings appear to be linked, supporting the ability of MRI to provide a detailed anatomy. Electrophysiological mapping combined with MRI is a useful tool for precise targeting in the subthalamic region.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Coste, J" sort="Coste, J" uniqKey="Coste J" first="J." last="Coste">J. Coste</name></region><name sortKey="Coste, J" sort="Coste, J" uniqKey="Coste J" first="J." last="Coste">J. Coste</name><name sortKey="Derost, P" sort="Derost, P" uniqKey="Derost P" first="P." last="Derost">P. Derost</name><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><name sortKey="Gabrillargues, J" sort="Gabrillargues, J" uniqKey="Gabrillargues J" first="J." last="Gabrillargues">J. Gabrillargues</name><name sortKey="Hemm, S" sort="Hemm, S" uniqKey="Hemm S" first="S." last="Hemm">S. Hemm</name><name sortKey="Lemaire, J J" sort="Lemaire, J J" uniqKey="Lemaire J" first="J. J." last="Lemaire">J. J. Lemaire</name><name sortKey="Lemaire, J J" sort="Lemaire, J J" uniqKey="Lemaire J" first="J. J." last="Lemaire">J. J. Lemaire</name><name sortKey="Ouchchane, L" sort="Ouchchane, L" uniqKey="Ouchchane L" first="L." last="Ouchchane">L. Ouchchane</name><name sortKey="Ouchchane, L" sort="Ouchchane, L" uniqKey="Ouchchane L" first="L." last="Ouchchane">L. Ouchchane</name><name sortKey="Sarry, L" sort="Sarry, L" uniqKey="Sarry L" first="L." last="Sarry">L. Sarry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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