[Parkinson's disease and rural environment].
Identifieur interne : 002587 ( Main/Exploration ); précédent : 002586; suivant : 002588[Parkinson's disease and rural environment].
Auteurs : Alexis Elbaz [France]Source :
- La Revue du praticien [ 0035-2640 ] ; 2007.
English descriptors
- KwdEn :
- Agricultural Workers' Diseases (chemically induced), Agricultural Workers' Diseases (epidemiology), Humans, Occupational Exposure, Parkinson Disease (epidemiology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (epidemiology), Pesticides (toxicity), Rural Health, Rural Population.
- MESH :
- chemical , toxicity : Pesticides.
- chemically induced : Agricultural Workers' Diseases, Parkinson Disease, Secondary.
- epidemiology : Agricultural Workers' Diseases, Parkinson Disease, Parkinson Disease, Secondary.
- Humans, Occupational Exposure, Rural Health, Rural Population.
Abstract
Parkinson's disease, the primary cause of parkinsonian syndrome, is, after Alzheimer's disease, the most frequent neurodegenerative disorder. Parkinson's disease is currently considered as a multifactorial disease resulting from the effect of genetic and environmental susceptibility. Several epidemiological studies have shown a moderate association between Parkinson's disease and farmer occupation or exposure to pesticides. Nevertheless, no product has been incriminated in a repeatable manner in these studies. The main methodological difficulty of these studies is associated with the complexity in assessing the occupational exposure to pesticides. The results of the toxicological studies point equally in this direction and provide arguments in favor of this relationship. However, some questions remain to be answered, particularly the role of low-dose exposure, the gene-environment interactions and the implied biological mechanisms.
Url:
PubMed: 17708091
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream PubMed, to step Curation: 000D40
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- to stream Ncbi, to step Curation: 000758
- to stream Ncbi, to step Checkpoint: 000758
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Parkinson's disease, the primary cause of parkinsonian syndrome, is, after Alzheimer's disease, the most frequent neurodegenerative disorder. Parkinson's disease is currently considered as a multifactorial disease resulting from the effect of genetic and environmental susceptibility. Several epidemiological studies have shown a moderate association between Parkinson's disease and farmer occupation or exposure to pesticides. Nevertheless, no product has been incriminated in a repeatable manner in these studies. The main methodological difficulty of these studies is associated with the complexity in assessing the occupational exposure to pesticides. The results of the toxicological studies point equally in this direction and provide arguments in favor of this relationship. However, some questions remain to be answered, particularly the role of low-dose exposure, the gene-environment interactions and the implied biological mechanisms.</div>
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