La maladie de Parkinson en France (serveur d'exploration)

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Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

Identifieur interne : 003237 ( Main/Exploration ); précédent : 003236; suivant : 003238

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathologic study

Auteurs : Bechir Jarraya [France] ; Anne-Marie Bonnet [France] ; Charles Duyckaerts [France] ; Jean-Luc Houetc [France] ; Philippe Cornu [France] ; Jean-Jacques Hauw [France] ; Yves Agid [France]

Source :

RBID : Pascal:04-0129063

Descripteurs français

English descriptors

Abstract

We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment.


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment.</div>
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