ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:14623353

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease

Identifieur interne : 003279 ( Main/Exploration ); précédent : 003278; suivant : 003280

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease

Auteurs : Olivier Guillin [France] ; Nathalie Griffon [France] ; Erwan Bezard [France] ; Ludovic Leriche [France] ; Jorge Diaz [France] ; Christian Gross [France] ; Pierre Sokoloff [France]

Source :

European journal of pharmacology [ 0014-2999 ] ; 2003.

RBID : Pascal:04-0477302

Descripteurs français

Pascal (Inist)
- Facteur BDNF, Récepteur dopaminergique D3, Parkinson maladie, Dopamine, Comportement, Sensibilisation, Dyskinésie.

English descriptors

KwdEn :
- Animals, Behavior, Brain derived neurotrophic factor, Brain-Derived Neurotrophic Factor (genetics), Brain-Derived Neurotrophic Factor (physiology), Brain-Derived Neurotrophic Factor (therapeutic use), D3 Dopamine receptor, Dopamine, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Dyskinesia, Gene Expression Regulation (drug effects), Humans, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson disease, Protein Binding (drug effects), Protein Binding (physiology), Receptors, Dopamine D2 (agonists), Receptors, Dopamine D2 (biosynthesis), Receptors, Dopamine D2 (genetics), Receptors, Dopamine D3, Sensitization.
MESH :
- chemical , agonists : Receptors, Dopamine D2.
- chemical , biosynthesis : Receptors, Dopamine D2.
- chemical , genetics : Brain-Derived Neurotrophic Factor, Receptors, Dopamine D2.
- chemical , pharmacology : Dopamine Agonists.
- chemical , physiology : Brain-Derived Neurotrophic Factor.
- chemical , therapeutic use : Brain-Derived Neurotrophic Factor, Dopamine Agonists.
- drug effects : Gene Expression Regulation, Protein Binding.
- drug therapy : Parkinson Disease.
- genetics : Parkinson Disease.
- metabolism : Parkinson Disease.
- physiology : Protein Binding.
- Animals, Humans, Receptors, Dopamine D3.

Abstract

Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to nerve growth factor, which are responsible for neuron proliferation, survival and differentiation. A more diverse role for BDNF as a neuronal extracellular transmitter has, nevertheless, been proposed. Here we show that BDNF synthesized by dopamine neurons is responsible for the appearance of the dopamine D3 receptor during development and maintains its expression in adults. Moreover, BDNF triggers behavioral sensitization to levodopa in hemiparkinsonian rats. In monkeys rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which develop levodopa-induced dyskinesia, we show an overexpression of this receptor. Administration of a dopamine D3 receptor-selective partial agonist strongly attenuated levodopa-induced dyskinesia, while leaving unaffected the therapeutic effect of levodopa. These results suggest that the dopamine D3 receptor participates in both dyskinesia and the therapeutic action of levodopa and that partial agonists may normalize dopamine D3 receptor function and correct side-effects of levodopa therapy in PD patients.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Behavior</term>
<term>Brain derived neurotrophic factor</term>
<term>Brain-Derived Neurotrophic Factor (genetics)</term>
<term>Brain-Derived Neurotrophic Factor (physiology)</term>
<term>Brain-Derived Neurotrophic Factor (therapeutic use)</term>
<term>D3 Dopamine receptor</term>
<term>Dopamine</term>
<term>Dopamine Agonists (pharmacology)</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Dyskinesia</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Humans</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson disease</term>
<term>Protein Binding (drug effects)</term>
<term>Protein Binding (physiology)</term>
<term>Receptors, Dopamine D2 (agonists)</term>
<term>Receptors, Dopamine D2 (biosynthesis)</term>
<term>Receptors, Dopamine D2 (genetics)</term>
<term>Receptors, Dopamine D3</term>
<term>Sensitization</term>
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<keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Facteur BDNF</term>
<term>Récepteur dopaminergique D3</term>
<term>Parkinson maladie</term>
<term>Dopamine</term>
<term>Comportement</term>
<term>Sensibilisation</term>
<term>Dyskinésie</term>
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<front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to nerve growth factor, which are responsible for neuron proliferation, survival and differentiation. A more diverse role for BDNF as a neuronal extracellular transmitter has, nevertheless, been proposed. Here we show that BDNF synthesized by dopamine neurons is responsible for the appearance of the dopamine D3 receptor during development and maintains its expression in adults. Moreover, BDNF triggers behavioral sensitization to levodopa in hemiparkinsonian rats. In monkeys rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which develop levodopa-induced dyskinesia, we show an overexpression of this receptor. Administration of a dopamine D3 receptor-selective partial agonist strongly attenuated levodopa-induced dyskinesia, while leaving unaffected the therapeutic effect of levodopa. These results suggest that the dopamine D3 receptor participates in both dyskinesia and the therapeutic action of levodopa and that partial agonists may normalize dopamine D3 receptor function and correct side-effects of levodopa therapy in PD patients.</div>
</front>
</TEI>
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La maladie de Parkinson en France (serveur d'exploration)

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson's disease

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	La maladie de Parkinson en France (serveur d'exploration)
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