ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:12589575

Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD

Identifieur interne : 003229 ( Main/Exploration ); précédent : 003228; suivant : 003230

Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD

Auteurs : F. Yekhlef [France] ; G. Ballan [France] ; F. Macia [France] ; O. Delmer [France] ; C. Sourgen [France] ; F. Tison [France]

Source :

Journal of neural transmission [ 0300-9564 ] ; 2003.

RBID : Pascal:03-0193321

Descripteurs français

Pascal (Inist)
- Imagerie RMN, Diagnostic, Homme, Parkinson maladie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Brain (pathology), Brain (physiopathology), Diagnosis, Human, Humans, Magnetic Resonance Imaging, Multiple System Atrophy (pathology), Multiple System Atrophy (physiopathology), Nuclear magnetic resonance imaging, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Retrospective Studies, Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology).
MESH :
- pathology : Brain, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- physiopathology : Brain, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- Humans, Magnetic Resonance Imaging, Retrospective Studies.

Abstract

We assessed the usefulness of routine MRI for the differential diagnosis of Parkinson's disease (PD) with "atypical" parkinsonian syndromes in everyday clinical practice. We studied routinely performed MRI in PD (n = 32), multiple system atrophy (MSA, n = 28), progressive supranuclear palsy (PSP, n = 30), and corticobasal degeneration (CBD, n = 26). From a preliminary analysis of 26 items, 4 independent investigators rated 11 easily recognizable MRI pointers organized as a simple scoring system. The frequency, severity and inter-rater agreement were determined. The total severity score was subdivided into "cortical", "putaminal", "midbrain", and "pontocerebellar" scores. The frequency of putaminal involvement (100%) and vermian cerebellar atrophy (45%) was significantly higher in MSA, but that of cortical atrophy (50%), midbrain atrophy and 3^rd ventricle enlargement (75%) was higher in PSP and CBD. The median total score fairly differentiated "atypical" parkinsonian syndromes from PD (positive predictive value-PPV-90%). However, the median total score was unable to differentiate atypical parkinsonian syndromes each other. The "cortical" score distinguished CBD and PSP from MSA with a fair PPV (>90%). The PPV of the "putaminal" score was high (70%) for the differential diagnosis of MSA with PSP and CBD. The "midbrain" score was significantly higher in PSP and CBD compared to MSA. These results are in accordance with the underlying pathology found in these disorders and demonstrate that a simple MRI scoring procedure may help the neurologist to differentiate primary causes of parkinsonism in everyday practice.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We assessed the usefulness of routine MRI for the differential diagnosis of Parkinson's disease (PD) with "atypical" parkinsonian syndromes in everyday clinical practice. We studied routinely performed MRI in PD (n = 32), multiple system atrophy (MSA, n = 28), progressive supranuclear palsy (PSP, n = 30), and corticobasal degeneration (CBD, n = 26). From a preliminary analysis of 26 items, 4 independent investigators rated 11 easily recognizable MRI pointers organized as a simple scoring system. The frequency, severity and inter-rater agreement were determined. The total severity score was subdivided into "cortical", "putaminal", "midbrain", and "pontocerebellar" scores. The frequency of putaminal involvement (100%) and vermian cerebellar atrophy (45%) was significantly higher in MSA, but that of cortical atrophy (50%), midbrain atrophy and 3<sup>rd</sup>
 ventricle enlargement (75%) was higher in PSP and CBD. The median total score fairly differentiated "atypical" parkinsonian syndromes from PD (positive predictive value-PPV-90%). However, the median total score was unable to differentiate atypical parkinsonian syndromes each other. The "cortical" score distinguished CBD and PSP from MSA with a fair PPV (>90%). The PPV of the "putaminal" score was high (70%) for the differential diagnosis of MSA with PSP and CBD. The "midbrain" score was significantly higher in PSP and CBD compared to MSA. These results are in accordance with the underlying pathology found in these disorders and demonstrate that a simple MRI scoring procedure may help the neurologist to differentiate primary causes of parkinsonism in everyday practice.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD

Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
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