Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6‐OHDA lesion in the rat brain
Identifieur interne : 003665 ( Main/Exploration ); précédent : 003664; suivant : 003666Riluzole reduces hyperactivity of subthalamic neurons induced by unilateral 6‐OHDA lesion in the rat brain
Auteurs : Oum-Kaltoum Hassani [France] ; Mireille Mouroux [France] ; Georg Andrees Bohme [France] ; Jean-Marie Stutzmann [France] ; Jean Féger [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Sodium.
English descriptors
- KwdEn :
- Adrenergic Agents, Animal, Animals, Benzothiazole, Chemotherapy, Dopaminergic neuron, Excitatory Amino Acid Antagonists (pharmacology), Excitotoxicity, Experimental disease, Functional Laterality, Inhibitor, Ionic channel, Male, Mechanism of action, Models, Animal, Neurons (drug effects), Neuroprotective Agents (pharmacology), Neuroprotective agent, Oxidopamine, Parkinson Disease (physiopathology), Parkinson Disease, Secondary (chemically induced), Parkinson disease, Parkinson's disease, Rat, Rats, Rats, Sprague-Dawley, Riluzole, Riluzole (pharmacology), Sodium, Sodium Channel Blockers (pharmacology), Substantia Nigra (drug effects), Substantia Nigra (pathology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (pathology), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, Treatment, basal ganglia, excitotoxicity, glutamate release, neurodegenerative diseases, neuroprotection, sodium channels blockers.
- MESH :
- chemical , pharmacology : Excitatory Amino Acid Antagonists, Neuroprotective Agents, Riluzole, Sodium Channel Blockers.
- chemical : Adrenergic Agents, Oxidopamine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Neurons, Substantia Nigra, Subthalamic Nucleus.
- pathology : Substantia Nigra, Subthalamic Nucleus.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- Animals, Functional Laterality, Male, Models, Animal, Rats, Rats, Sprague-Dawley.
Abstract
An abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmission, affects neuronal activity in this brain region. Intravenous administration of riluzole reduced the discharge rate of subthalamic neurons in rats with 6‐OHDA‐induced lesions of the midbrain. By contrast, no effect was observed in nonlesioned control animals. This property may contribute to the neuroprotective effects of riluzole in animal models of PD through the modulation of the glutamatergic inputs these neurons feedback to nigral dopaminergic neurons. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1219
Affiliations:
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Le document en format XML
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<term>Animals</term>
<term>Benzothiazole</term>
<term>Chemotherapy</term>
<term>Dopaminergic neuron</term>
<term>Excitatory Amino Acid Antagonists (pharmacology)</term>
<term>Excitotoxicity</term>
<term>Experimental disease</term>
<term>Functional Laterality</term>
<term>Inhibitor</term>
<term>Ionic channel</term>
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<term>Models, Animal</term>
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<term>Neuroprotective Agents (pharmacology)</term>
<term>Neuroprotective agent</term>
<term>Oxidopamine</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Rat</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Riluzole</term>
<term>Riluzole (pharmacology)</term>
<term>Sodium</term>
<term>Sodium Channel Blockers (pharmacology)</term>
<term>Substantia Nigra (drug effects)</term>
<term>Substantia Nigra (pathology)</term>
<term>Subthalamic Nucleus (drug effects)</term>
<term>Subthalamic Nucleus (pathology)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
<term>basal ganglia</term>
<term>excitotoxicity</term>
<term>glutamate release</term>
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<term>Sodium Channel Blockers</term>
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<term>Benzothiazole</term>
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<term>Inhibiteur</term>
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<front><div type="abstract" xml:lang="en">An abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmission, affects neuronal activity in this brain region. Intravenous administration of riluzole reduced the discharge rate of subthalamic neurons in rats with 6‐OHDA‐induced lesions of the midbrain. By contrast, no effect was observed in nonlesioned control animals. This property may contribute to the neuroprotective effects of riluzole in animal models of PD through the modulation of the glutamatergic inputs these neurons feedback to nigral dopaminergic neurons. © 2001 Movement Disorder Society.</div>
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