Glial cells and Parkinson's disease.
Identifieur interne : 003881 ( Main/Exploration ); précédent : 003880; suivant : 003882Glial cells and Parkinson's disease.
Auteurs : E C Hirsch [France]Source :
- Journal of neurology [ 0340-5354 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- metabolism : Neuroglia.
- pathology : Neuroglia, Parkinson Disease.
- physiopathology : Parkinson Disease.
- Humans.
Abstract
Parkinson's disease is a neurodegenerative disease characterised by a massive loss of dopaminergic neurons in the substantia nigra. Yet glial cells may also participate in the pathophysiology of the disease. Indeed, glial cells can produce trophic factors which may stimulate neuronal survival or, alternatively, they could produce toxic compounds which may be involved in neuronal degeneration. This paper reviews the potentially protective or deleterious effects of glial cells in the substantia nigra of patients with Parkinson's disease.
PubMed: 10991667
Affiliations:
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Le document en format XML
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